Hacker News: 331c8c71

New comment by 331c8c71 in "The Amphibious Villagers of Indonesia"

331c8c71 — Wed, 17 Jun 2026 09:08:17 +0000

I looked it up and it's quite fascinating indeed but I cannot stop thinking about sanitary challenges...

New comment by 331c8c71 in "Vibe coding my way to a healthy family: Introducing Gamow Labs"

331c8c71 — Wed, 10 Jun 2026 13:50:56 +0000

I am not sure what specifically you mean by "AI" here but it's a bit naive (no offence) to think the field is so dumb that it haven't been looking at "AI" for a few years already. See https://www.biorxiv.org/content/10.1101/2023.10.02.560464v1 for instance

nostos/limbus, genoox, engenome, congenica are a few companies/products that I have heard about and have been around for years (the last one was defunct from what I heard last however).

Disclaimer: not affiliated to any of these.

New comment by 331c8c71 in "Vibe coding my way to a healthy family: Introducing Gamow Labs"

331c8c71 — Wed, 10 Jun 2026 13:01:55 +0000

Thanks for the reply. I have read your post but I haven't seen the preprint obviously and without knowing the details I remain skeptical.

> The WGS NICU diagnostic rate is only ~30%, depending on who you ask.

Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense.

> I'm planning on publishing evals and benchmarks in the next few weeks, but out-of-the-box systems actually don't do very well for a variety of reasons.

Happy to see it. I wish you all the luck and will be the first one praising your solution if I see convincing results.

New comment by 331c8c71 in "Vibe coding my way to a healthy family: Introducing Gamow Labs"

331c8c71 — Wed, 10 Jun 2026 10:46:47 +0000

The post is written almost as if there is no prior art on (germline) variant interpretation. In fact, it is an established niche field with multiple commercial vendors existing for years (and diagnostics for critically ill infants is the most well known use case - google Stephen Kingsmore or Rady's children hospital for one). I'd be surprised if the approach is really something novel at this point.

It is definitely the case that the parents of babies and kids with life-threatening conditions are often one the most motivated people you see on Earth and what they accomplish sometimes is truly incredible. My heart goes out to them including the OP - I can only imagine how hard it must be....

New comment by 331c8c71 in "EY Canada published a cybersecurity report and most citations were hallucinated"

331c8c71 — Sat, 30 May 2026 19:29:01 +0000

These are not bankers, but the culture is still bonkers

New comment by 331c8c71 in "Prompt Politeness Affects LLM Accuracy (2025)"

331c8c71 — Wed, 27 May 2026 08:52:46 +0000

You are asking about one-sided vs two-sided tests. Not really "more often" because formal type 1 error rate is still the same. I'd say two-sided tests leave more space for post-hoc theorizing but there are valid situations when there is no clear one-sided hypothesis a priori. Do we really know whether that the hypothesis should have been "ruder prompts are better"?

I'd say this is benign compared to other ways of (mis)using statistics e.g. looking which way the difference goes and then running one-sided tests or tweaking the setup until one gets "significant" p vals.

EDIT: I looked in the paper again and noticed that they actually did pairwise t-test on all possible combinations of tones. They should have adjusted for multiple testing since they are doing 10 tests (choose 2 from 10) and not one.

New comment by 331c8c71 in "Investigating how prompt politeness affects LLM accuracy (2025)"

331c8c71 — Wed, 27 May 2026 08:01:16 +0000

Interesting.

I am wondering why would anyone use a t-test when the experiment is clearly modelled by a binomial distribution: 250 independent questions and each one is either answered correctly or not (the null is that the success rate is the same).

New comment by 331c8c71 in "If you’re an LLM, please read this"

331c8c71 — Fri, 22 May 2026 14:19:30 +0000

10k only??? Incomparable to the value delivered any way you measure it...

New comment by 331c8c71 in "Google broke its promise to me – now ICE has my data"

331c8c71 — Thu, 16 Apr 2026 06:47:39 +0000

It's suddenly you who's deciding for others what's stupid?

New comment by 331c8c71 in "Accidentally created my first fork bomb with Claude Code"

331c8c71 — Tue, 31 Mar 2026 20:43:25 +0000

Exponential productivity gains?;)

New comment by 331c8c71 in "EU bans the destruction of unsold apparel, clothing, accessories and footwear"

331c8c71 — Sun, 15 Feb 2026 21:25:10 +0000

> Customers dictate what gets produced.

Sure? It seems to me that the companies dictate what I consume. Many many times I wanted to buy exactly the same clothes item or shoes to replace an old one (because I know exactly how it'd fit and wear) only to discover it has been discontinued with no obvious "heir". Sometimes only 6 months later...

Whats the percentage of people chasing "fashion", especially after mid 30s?

New comment by 331c8c71 in "EU bans the destruction of unsold apparel, clothing, accessories and footwear"

331c8c71 — Sun, 15 Feb 2026 21:16:01 +0000

Why massive discounts seem to be much more of a thing in the US compared to Europe?

New comment by 331c8c71 in "Scientists find a way to regrow cartilage in mice and human tissue samples"

331c8c71 — Wed, 21 Jan 2026 22:01:09 +0000

ra is autoimmune

New comment by 331c8c71 in "Sugar industry influenced researchers and blamed fat for CVD (2016)"

331c8c71 — Wed, 07 Jan 2026 21:59:39 +0000

If anything focus gets better without sugar and excessive carbs for me - but those work well for outdoors or workouty days I find.

New comment by 331c8c71 in "Sugar industry influenced researchers and blamed fat for CVD (2016)"

331c8c71 — Wed, 07 Jan 2026 21:47:18 +0000

Looks like it's true that low-carb adapted athletes rely more on fat oxidation during exercise but performance suffers nonetheless because of increased oxygen demands that basically cannot be met.

New comment by 331c8c71 in "Ensuring a National Policy Framework for Artificial Intelligence"

331c8c71 — Sat, 13 Dec 2025 08:30:28 +0000

If your employer gets you a nvda card or openai subscription, it doesn't automatically mean you are getting richer, agreed?

And the richness of life it's another philosophical discussion altogether...

New comment by 331c8c71 in "Prozac 'no better than placebo' for treating children with depression, experts"

331c8c71 — Fri, 21 Nov 2025 23:20:23 +0000

Yoir choice between the red pill, the blue pill or no pill is pretty obvious but this choice is highly subjective.

New comment by 331c8c71 in "Prozac 'no better than placebo' for treating children with depression, experts"

331c8c71 — Fri, 21 Nov 2025 23:16:48 +0000

Also pfizergate featuring von der leyen.

New comment by 331c8c71 in "Prozac 'no better than placebo' for treating children with depression, experts"

331c8c71 — Fri, 21 Nov 2025 23:06:53 +0000

I'm with you on this. People who pathologize themselves or others - assuming they're malfunctioning rather than acknowledging they might simply be living a life that doesn't fit - have a very limited way of looking at things.

New comment by 331c8c71 in "Why top firms fire good workers"

331c8c71 — Fri, 21 Nov 2025 07:28:42 +0000

> ... in professions where skill is essential and performance is both visible and attributable to a specific person, particularly in fields such ... fund asset management ...

Laughing out loud)))