Hacker News: 88e282102ae2e5b

New comment by 88e282102ae2e5b in "Get Smart with SmartOS"

88e282102ae2e5b — Tue, 04 Dec 2018 19:04:08 +0000

Ah, I see, thanks. Still, that's a non-starter. Many of the packages I use are not available through any system package manager, and it would preclude using virtualenvs.

OTOH, I desperately want to move away from Python.

New comment by 88e282102ae2e5b in "Get Smart with SmartOS"

88e282102ae2e5b — Tue, 04 Dec 2018 17:10:13 +0000

The problem is, I am using the package manager (pip in this case). I guess because the wheels aren't built for SmartOS it has to compile them.

New comment by 88e282102ae2e5b in "Get Smart with SmartOS"

88e282102ae2e5b — Tue, 04 Dec 2018 15:36:55 +0000

I really wish I could use SmartOS, but I couldn't even install some common Python packages without getting a compilation error. Looking such problems up on issue trackers revealed old requests for compatibility with SmartOS, and no follow-up from the developers.

I'm not sure what the recourse is, I just don't know enough about C to fix this myself. I assumed this would be a common enough problem that the solution would be well documented somewhere but there seems to be nothing out there even mentioning the issue.

I'm happy to do all my work in LX-branded zones, and that's certainly better than the alternatives (for my purposes), but having two operating systems still kinda irks me.

New comment by 88e282102ae2e5b in "Phase-Separating Proteins May Protect and Regulate Cells"

88e282102ae2e5b — Tue, 27 Nov 2018 04:15:09 +0000

Biophysics and biochemistry would both fit the bill.

I would not take the site you linked seriously - it's the ramblings of a crackpot. If you happen to have a biology background and would like to debate this, I'd be happy to elaborate.

New comment by 88e282102ae2e5b in "$200 retail whole genome sequencing now available"

88e282102ae2e5b — Fri, 23 Nov 2018 04:50:12 +0000

Is there anything more to it than carving a piece of silica and ligating the adapters to the surface? I mean, I know the process is a bit more involved than that but the patents make it seem relatively straightforward.

New comment by 88e282102ae2e5b in "$200 retail whole genome sequencing now available"

88e282102ae2e5b — Fri, 23 Nov 2018 03:58:05 +0000

This is a huge red flag for me. Maybe if you made your own bootleg flow cells and reagents? But even that seems like a stretch.

New comment by 88e282102ae2e5b in "Ask HN: Has anyone undergone stem cell treatment for auto-immune disease?"

88e282102ae2e5b — Mon, 05 Nov 2018 20:39:22 +0000

That's fair, my generalization was pejorative. I meant to say, in a glib way, that this is not a website frequented by 100% licensed physicians and clinical researchers, and is actually mostly not that.

The point is, the OP is essentially saying, "I wish to discard the notion that statistical research is valid and may make medical decisions based on a study with N=1 or 2". I was worried people would show up and offer magical cures as they always do, and lo and behold, there are threads suggesting hypnosis and turmeric.

My main concern with this is that the OP may use a completely arbitrary "cure" and avoid speaking further to doctors about it, so any actual treatments that are developed might be overlooked.

New comment by 88e282102ae2e5b in "Ask HN: Has anyone undergone stem cell treatment for auto-immune disease?"

88e282102ae2e5b — Mon, 05 Nov 2018 20:27:52 +0000

It can also make things actively worse - it's not just additional information, but potentially disinformation.

New comment by 88e282102ae2e5b in "Ask HN: Has anyone undergone stem cell treatment for auto-immune disease?"

88e282102ae2e5b — Mon, 05 Nov 2018 15:03:49 +0000

I can't help, but I can guarantee you that getting unlicensed medical advice from web developers won't make things better.

New comment by 88e282102ae2e5b in "Pre-Existing Immunity to CRISPR Found in 96% of People in Study"

88e282102ae2e5b — Wed, 31 Oct 2018 00:34:22 +0000

Cpf1 is patented, it's just that there's no dispute over who owns it.

New comment by 88e282102ae2e5b in "Pre-Existing Immunity to CRISPR Found in 96% of People in Study"

88e282102ae2e5b — Wed, 31 Oct 2018 00:32:41 +0000

No. Working around this takes some effort but is straightforward and uses well-known, existing techniques. There's a lab I know of that considered trying to modify the protein so it could evade the immune system, but they decided against it since they figured the group that published this paper would have too much of a head start and there's no way they'd be able to compete. I'd give it a year or so, and that's assuming none of the other Cas9 or Cas12a variants are already usable.

New comment by 88e282102ae2e5b in "With Proton and Steam Play, many Windows games now work on Linux"

88e282102ae2e5b — Mon, 29 Oct 2018 16:29:45 +0000

I've been happy just dual-booting Windows and Linux. Windows 10 is free as long as you don't care about personalizing it, which I definitely don't, since it's just for games. I look forward to having a Linux-only machine but I'm not in any hurry.

New comment by 88e282102ae2e5b in "Ask HN: Over 60 = no engineering jobs?"

88e282102ae2e5b — Wed, 17 Oct 2018 16:50:23 +0000

Also, consider this from the manager's perspective. They have to ask themselves: if this person has 35 years of experience, they must have a substantial network, so why aren't they just tapping that resource? Not a single person from this applicant's past wants to give them an interview?

New comment by 88e282102ae2e5b in "Hydrogen derived from ammonia could open up new export market for Australia"

88e282102ae2e5b — Wed, 08 Aug 2018 14:11:31 +0000

> So the input for this technology is imaginary.

They proposed one use, which would be to use it as storage for solar/wind power. Perhaps their plan is that when there's excess output from renewables, they'll use electrolysis to generate hydrogen gas from water?

Ask HN: What is the most unethical thing you've done as a programmer?

88e282102ae2e5b — Sun, 05 Aug 2018 16:17:33 +0000

There was an article a while back about how cell service providers were selling extremely granular location data, and some of the programmers working on those systems immediately showed up on HN to comment on their moral dilemma. I suspect it's not an isolated case.

Comments URL: https://news.ycombinator.com/item?id=17692005

Points: 432

# Comments: 494

New comment by 88e282102ae2e5b in "Ask HN: Has anyone experienced workplace training that made a difference?"

88e282102ae2e5b — Wed, 25 Jul 2018 22:01:16 +0000

I did see a video that explained how to correctly handle high pressure gas cylinders, which did teach me some critical things on not getting myself or others killed.

New comment by 88e282102ae2e5b in "Dying Organs Restored to Life in Novel Experiments"

88e282102ae2e5b — Thu, 19 Jul 2018 14:32:48 +0000

I was also surprised by this. In the papers where they did this work, they discuss many previously-known mechanisms for intercellular mitochondrial transfer - apparently cells can form nanotubes and exchange organelles, and that's relatively well-studied. That's not what's happening here, though, and they state that the mechanism at play is unknown.

New comment by 88e282102ae2e5b in "US cell carriers are selling access to real-time phone location data"

88e282102ae2e5b — Wed, 16 May 2018 17:00:44 +0000

Are you able to send them a copy of their individual location data, or the location data of their staffers/friends/family? That might make for a potent wake up call. Though, you'd want to run that by an attorney first.

New comment by 88e282102ae2e5b in "Is IPv6 only for the Rich? [pdf]"

88e282102ae2e5b — Sun, 13 May 2018 20:17:20 +0000

Is there a reason ISPs would be reluctant to discuss their motivations for IPv6 deployment? That is, why can't you just ask them?

New comment by 88e282102ae2e5b in "Researchers have developed a water-based battery to store solar and wind energy"

88e282102ae2e5b — Tue, 08 May 2018 13:01:41 +0000

I dunno...academic funding is dysfunctional and this kind of hyperoptimistic prediction can help you get your next grant.