Hacker News: Kalanos

New comment by Kalanos in "The "confident idiot" problem: Why AI needs hard rules, not vibe checks"

Kalanos — Mon, 08 Dec 2025 13:21:38 +0000

Please refer to this as GenAI

New comment by Kalanos in "American Heart Association says melatonin may be linked to serious heart risks"

Kalanos — Sun, 09 Nov 2025 23:42:16 +0000

https://newsroom.heart.org/news/long-term-use-of-melatonin-s...

New comment by Kalanos in "Ask HN: I underestimated how lonely building solo can be"

Kalanos — Sun, 09 Nov 2025 17:58:19 +0000

Good idea. Previously, I joined a python slack community and it helped a lot

New comment by Kalanos in "PSF has withdrawn $1.5M proposal to US Government grant program"

Kalanos — Tue, 28 Oct 2025 02:47:27 +0000

pypi put out a survey a while back that was full of bs questions about dei fluff. the lack of subject matter made me really question the competence of the project staff.

New comment by Kalanos in "The allure of new languages vs. the necessity of problem-solving"

Kalanos — Tue, 23 Sep 2025 00:22:07 +0000

Yes! Why is every company hiring for LLM talent? Companies that have no business doing so. They probably don't even know that supervised machine learning exists.

New comment by Kalanos in "Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out"

Kalanos — Wed, 17 Sep 2025 02:31:57 +0000

In the US, there is no male test for HPV

Tell HN: Chrome and Spotify dropping support for macOS11

Kalanos — Sat, 09 Aug 2025 12:02:42 +0000

My 2014 MacBook Pro is locked to macOS 11.7.10

Chrome: "To get future Google chrome updates, you'll need macOS 12 or later"

Spotify: "Your OS is out of date. To enjoy Spotify's latest features, upgrade to a newer version."

Comments URL: https://news.ycombinator.com/item?id=44845864

Points: 9

# Comments: 7

New comment by Kalanos in "'Click-to-cancel' rule is blocked"

Kalanos — Fri, 11 Jul 2025 14:22:30 +0000

"FTC made a procedural error by failing to come up with a preliminary regulatory analysis, which is required"

New comment by Kalanos in "AlphaGenome: AI for better understanding the genome"

Kalanos — Fri, 27 Jun 2025 13:52:20 +0000

The functional predictions related to "non-coding" variants are big here. Non-coding regions, referred to as the dark genome, produce regulatory non-coding RNA's that determine the level of gene expression in a given cell type. There are more regulatory RNA's than there are genes. Something like 75% of expression by volume is ncRNA.

New comment by Kalanos in "We’re secretly winning the war on cancer"

Kalanos — Wed, 11 Jun 2025 14:49:48 +0000

Despite an aging population

New comment by Kalanos in "NSF faces shake-up as officials abolish its 37 divisions"

Kalanos — Fri, 09 May 2025 14:34:22 +0000

No. Pharma acquires these gov-funded companies. The gov de-risks them for pharma.

New comment by Kalanos in "Tumor-derived erythropoietin acts as immunosuppressive switch in cancer immunity"

Kalanos — Sat, 26 Apr 2025 16:35:51 +0000

somatic = cancer. germline = inherited.

New comment by Kalanos in "Tumor-derived erythropoietin acts as immunosuppressive switch in cancer immunity"

Kalanos — Fri, 25 Apr 2025 18:46:06 +0000

You're right, DNA damage is just one of the types of genetic variation in cancer. There are many other structural variations that act like remixes.

"Maybe we need to start culturing and DNA testing cancers." I assure you this is being done at a massive scale.

Due to cellular stress, cancer cells disobey multi-cellular governance. They behave more like independent organisms fighting for survival, reverting to primal programming.

New comment by Kalanos in "Preview: Amazon S3 Tables and Lakehouse in DuckDB"

Kalanos — Tue, 18 Mar 2025 17:23:46 +0000

Haven't tried it. S3 Tables sounds like a great idea. However, I am wary. For it to be useful, a suite of AWS services probably needs to integrate with it. These services are all managed by different teams that don't always work well together out of the box and often compete with redundant products. For example, configuring SageMaker Studio to use an EMR cluster for Spark was a multi-day hassle with a lot of custom (insecure?) configuration. How is this different from other existing table offerings? AWS is a mess.

New comment by Kalanos in "MacBook Air M4"

Kalanos — Wed, 05 Mar 2025 16:06:15 +0000

16GB base!

New comment by Kalanos in "Our Epidemic of Loneliness and Isolation [pdf] (2023)"

Kalanos — Mon, 24 Feb 2025 15:37:37 +0000

I really like this surgeon general. Hope he doesn't get axed.

He is also taking a stance on alcohol in relation to hormonally driven tumor development.

New comment by Kalanos in "WhiteSur: macOS-like theme for GTK desktops"

Kalanos — Sun, 23 Feb 2025 19:11:09 +0000

For normies, does this work on Ubuntu?

New comment by Kalanos in "Show HN: I Built a Visual Workflow Automation Platform – FlowRipple"

Kalanos — Sat, 22 Feb 2025 16:57:20 +0000

does that have the same degree of cloud integrations as airflow?

New comment by Kalanos in "Perplexity Deep Research"

Kalanos — Sun, 16 Feb 2025 22:13:31 +0000

It's producing more in-depth answers than alternatives, but the results are not as accurate as alternatives.

New comment by Kalanos in "AI isn't going to build your startup"

Kalanos — Sat, 15 Feb 2025 00:21:44 +0000

+1 "The hardest part isn't the building"

That's the first thing I thought when I read the title.