Hacker News: Kalanos

New comment by Kalanos in "Civilians under siege by Mexican cartel fight back with AK-47s, grenades"

Kalanos — Fri, 07 Aug 2026 22:01:22 +0000

where exactly are you going to grow cocaine? on the cartel's land?

New comment by Kalanos in "Civilians under siege by Mexican cartel fight back with AK-47s, grenades"

Kalanos — Thu, 06 Aug 2026 21:39:47 +0000

the real war the US should be fighting

New comment by Kalanos in "Meta Ran Ads That Contained AI-Generated Child Sexual Abuse Imagery"

Kalanos — Wed, 05 Aug 2026 21:03:58 +0000

What's crazy is how long it takes to report something like this to a big company and actually have them take action on it. I remember 10 years ago I reported a Giphy ad for the same thing, and it took them months to take action.

New comment by Kalanos in "Changes at Google DeepMind: Demis Hassabis from CEO to Chair, Jeff Dean departs"

Kalanos — Wed, 05 Aug 2026 21:02:11 +0000

Gemini has been improving by what feels like 1% every week

New comment by Kalanos in "Learning a few things about running SQLite"

Kalanos — Sun, 19 Jul 2026 00:36:56 +0000

I tried WAL, but like you said, it froze up during multiple writes (when creating records, not updating). I guess what I needed was a write queue - not sure if that exists.

New comment by Kalanos in "Learning a few things about running SQLite"

Kalanos — Sun, 19 Jul 2026 00:30:19 +0000

sharding locally defeats the purpose of sharding; splitting it up across machines to get more resources

New comment by Kalanos in "Learning a few things about running SQLite"

Kalanos — Fri, 17 Jul 2026 20:23:02 +0000

It's great! However, it's only meant for local systems. Once you need to connect over a network or robustly handle simultaneous requests, you need something like postgres.

New comment by Kalanos in "Primate Is the Last Great Web Framework"

Kalanos — Wed, 15 Jul 2026 17:28:30 +0000

It's an MVC that handles realtime frontend without React?

New comment by Kalanos in "The "confident idiot" problem: Why AI needs hard rules, not vibe checks"

Kalanos — Mon, 08 Dec 2025 13:21:38 +0000

Please refer to this as GenAI

New comment by Kalanos in "American Heart Association says melatonin may be linked to serious heart risks"

Kalanos — Sun, 09 Nov 2025 23:42:16 +0000

https://newsroom.heart.org/news/long-term-use-of-melatonin-s...

New comment by Kalanos in "Ask HN: I underestimated how lonely building solo can be"

Kalanos — Sun, 09 Nov 2025 17:58:19 +0000

Good idea. Previously, I joined a python slack community and it helped a lot

New comment by Kalanos in "PSF has withdrawn $1.5M proposal to US Government grant program"

Kalanos — Tue, 28 Oct 2025 02:47:27 +0000

pypi put out a survey a while back that was full of bs questions about dei fluff. the lack of subject matter made me really question the competence of the project staff.

New comment by Kalanos in "The allure of new languages vs. the necessity of problem-solving"

Kalanos — Tue, 23 Sep 2025 00:22:07 +0000

Yes! Why is every company hiring for LLM talent? Companies that have no business doing so. They probably don't even know that supervised machine learning exists.

New comment by Kalanos in "Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out"

Kalanos — Wed, 17 Sep 2025 02:31:57 +0000

In the US, there is no male test for HPV

Tell HN: Chrome and Spotify dropping support for macOS11

Kalanos — Sat, 09 Aug 2025 12:02:42 +0000

My 2014 MacBook Pro is locked to macOS 11.7.10

Chrome: "To get future Google chrome updates, you'll need macOS 12 or later"

Spotify: "Your OS is out of date. To enjoy Spotify's latest features, upgrade to a newer version."

Comments URL: https://news.ycombinator.com/item?id=44845864

Points: 9

# Comments: 7

New comment by Kalanos in "'Click-to-cancel' rule is blocked"

Kalanos — Fri, 11 Jul 2025 14:22:30 +0000

"FTC made a procedural error by failing to come up with a preliminary regulatory analysis, which is required"

New comment by Kalanos in "AlphaGenome: AI for better understanding the genome"

Kalanos — Fri, 27 Jun 2025 13:52:20 +0000

The functional predictions related to "non-coding" variants are big here. Non-coding regions, referred to as the dark genome, produce regulatory non-coding RNA's that determine the level of gene expression in a given cell type. There are more regulatory RNA's than there are genes. Something like 75% of expression by volume is ncRNA.

New comment by Kalanos in "We’re secretly winning the war on cancer"

Kalanos — Wed, 11 Jun 2025 14:49:48 +0000

Despite an aging population

New comment by Kalanos in "NSF faces shake-up as officials abolish its 37 divisions"

Kalanos — Fri, 09 May 2025 14:34:22 +0000

No. Pharma acquires these gov-funded companies. The gov de-risks them for pharma.

New comment by Kalanos in "Tumor-derived erythropoietin acts as immunosuppressive switch in cancer immunity"

Kalanos — Sat, 26 Apr 2025 16:35:51 +0000

somatic = cancer. germline = inherited.