cool project btw

OK thank you layman for your ad-hominem, I have extensive expertise in medecine and pharmacology and have extensively studied the thymus, spleen, associated peptides and immune and aging biomarkers, so what seems to you as gibberish is actual valid statements or for a few ones, very reasonable and necessary to be asked speculations. But indeed, an expert is often difficult to distinguish from a bullshitter when the layman lacks discernment, a formation in epistemology nor care to check any of the sourced premises.

> why would that "budget" be "for vaccines" _only_ ?

Well for starters I do not question wether there is a budget limit, there is it is a fact. I even explain in detail that a necessary component in the equation are naive lymphocite T and that aging and environement stressors induce an atrophy (involution/shrinkage) of the thymus and therefore of the total number of differentiated mature lymphocytes T. Also obviously I do not say that this only apply for vaccines, real covid is not much different from the spike protein and in fact induce more damage, however the question has to be asked, regardless.

> consider what answer would have better evolutionary fitness

and yet having a limit is an evolutionary fitness as show the existence of thymus involution, both for reduced energy use and programmed aging evolutionnary benefits as shows the many papers on the topic. Obviously, as you should have guessed, the limit only matter to not be reached before the age of reproduction, which is < 20 years old

I suppose that 1) vaccines increase the rate of specialisation of naive T cells to mature t cells (hence the number of naive t cells diminish supraphysically)and I also believe that

2) those specific mature T cells, generating covid spike protein specific antibodies, have lost some or total ability to fight non-covid diseases as a cost of specialization. 1) would increase thymus involution rate and therefore age speed of immunosupression.

2) would reduce generic immune ability (learning other pathogens)

3) I believe the increased immune profile after a vaccine induce a long lasting (at least 6 month) increase of accelerated aging process in humans, via increased inflammation and therefore apoptosis, DNA mutations and oxidative stress, although in a mild form and hence in the medium term asymptomatic.

Above all the premises I enumerated, the 2) is the one I would draw the most attention to, which can be reformulated as: do the repetitive administrations of a vaccine (here the 3 mRNA doses), reduce the effectiveness of the immune system for future non-COVID diseases, and even more importantly, does those doses reduce the immune learnability budget and therefore do those vaccines reduce the effectiveness of future vaccines against the next non-COVID pandemic? There has to be a limit to immune memory, the question is, after how many vaccines do the effect become non-negligible on aging?

study backing chronic inflammation and therefore accelerated aging: > vaccine-induced hypermetabolic lymph nodes https://pubmed.ncbi.nlm.nih.gov/34857663/

study backing the depletion of lymphocite T helper cell production: Study Shows Immune Cells Against Covid-19 Stay High in Number Six Months After Vaccination https://www.hopkinsmedicine.org/news/newsroom/news-releases/....

Moreover, I have an issue understanding why would vaccine not massively lose effectiveness after the age of 70 since at 70 the thymus has ~completely involuted (although maybe the stem cells in the bone marrow suffice?).

The one that will build this will enable a disruptive market where people can finally become much closer to their ideal self, by the effective means of social pressure, real-time e-coaching and monetary incentive. Does this actually exists?

Comments URL: https://news.ycombinator.com/item?id=31528294

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