<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: TaupeRanger</title><link>https://news.ycombinator.com/user?id=TaupeRanger</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Mon, 15 Jun 2026 19:12:11 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=TaupeRanger" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by TaupeRanger in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"]]></title><description><![CDATA[
<p>The word "benefit" does not apply here. The only "benefits" patients and families care about are: 1) does the patient live longer, and/or 2) does the quality of life improve in a meaningful way? Amyloid plaques are a <i>surrogate</i> marker, and (as already explained by many people in this thread) have not been established as a causal factor in disease. In fact, some work has even suggested a <i>protective role</i> for plaques. So we do not have enough evidence to say that a 42% reduction in amyloid-beta IN MICE relays any benefit at all to humans.<p>You are correct that a series of clinical trials, which would take 7-10 years, would clear things up. But for now, we simply don't know.</p>
]]></description><pubDate>Mon, 15 Jun 2026 18:17:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=48545091</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48545091</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48545091</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"]]></title><description><![CDATA[
<p>Flagged. Nonsense puff piece by the university. The headline itself is beyond terrible - this is a mouse model and would need years of further successful research to be able to say that it "restores memory" in any meaningful way, let alone in actual humans.</p>
]]></description><pubDate>Mon, 15 Jun 2026 16:17:10 +0000</pubDate><link>https://news.ycombinator.com/item?id=48543493</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48543493</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48543493</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"]]></title><description><![CDATA[
<p>You are wrong. This paper very clearly does <i>not</i> show that it "works".  The debate exists for a good reason - the very thing this paper claims to show is the <i>exact thing</i> the person you replied to was questioning. And that is a central question in all of Alzheimer's research.<p>There are dozens of studies that show mice improving their memory/spatial reasoning as Alzheimer's models. <i>None</i> of them have led to a proven improvement in longevity or quality of life for human Alzheimer's patients. Some of them slightly slow the progression, but even then you're getting into a gray area - is it really "better" to be stuck in the Alzheimer's fog for <i>longer</i>? Are we actually improving quality of life? It's unclear.<p>So no, in order for us to say that this approach "works", we would need randomized controlled clinical trials in <i>humans</i> showing a strict improvement in quality of life and/or longevity. This is not even close to that level of evidence.</p>
]]></description><pubDate>Mon, 15 Jun 2026 16:14:58 +0000</pubDate><link>https://news.ycombinator.com/item?id=48543456</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48543456</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48543456</guid></item><item><title><![CDATA[New comment by TaupeRanger in "New pancreatic cancer drug might open the door to much longer survival times"]]></title><description><![CDATA[
<p>I have had a family member die of pancreatic cancer before age 60. It is, of course, terrible beyond belief. I'm not sure what you mean by "SOP" in this context. Referencing a bio-plausible mechanism is not actually clinically meaningful. It can provide a direction for study, but does not replace an actual clinical trial. As I said, "a patient can try anything they want".<p>But since we don't actually know whether such a recommendation will harm or help any individual patient, no one should be taking this recommendation as advice, and at the very least you should not be "highly recommending" specific dietary changes to people based on one anecdotal experience.</p>
]]></description><pubDate>Sat, 13 Jun 2026 21:58:10 +0000</pubDate><link>https://news.ycombinator.com/item?id=48521900</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48521900</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48521900</guid></item><item><title><![CDATA[New comment by TaupeRanger in "New pancreatic cancer drug might open the door to much longer survival times"]]></title><description><![CDATA[
<p>They are working on getting in vivo studies going from what I remember - it's going to take a positive result in a trial on real patients to get attention - that's just how medicine works. You have to show it actually improves longevity and/or patient quality of life before anyone has a reason to care.</p>
]]></description><pubDate>Sat, 13 Jun 2026 19:45:59 +0000</pubDate><link>https://news.ycombinator.com/item?id=48520737</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48520737</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48520737</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Treating pancreatic tumours may have revealed cancer's master switch"]]></title><description><![CDATA[
<p>Unfortunately, anecdotes are not data, and although a patient can try anything they want, there is no way to know that such dietary changes are beneficial or potentially harmful for most patients without doing a randomized controlled trial and hoping for strong adherence from the participants.</p>
]]></description><pubDate>Sat, 13 Jun 2026 19:44:13 +0000</pubDate><link>https://news.ycombinator.com/item?id=48520715</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48520715</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48520715</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Open source AI must win"]]></title><description><![CDATA[
<p>For now. Progress in hardware/model efficiency is one of the threats the big AI labs face, because if LLMs become commoditized they can’t make back the billions they spent.</p>
]]></description><pubDate>Sat, 13 Jun 2026 14:36:27 +0000</pubDate><link>https://news.ycombinator.com/item?id=48517763</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48517763</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48517763</guid></item><item><title><![CDATA[New comment by TaupeRanger in "CRISPR tech selectively shreds cancer cells, including "undruggable" cancers"]]></title><description><![CDATA[
<p>I'm not sure what this comment means - we could <i>always</i> kill cancer cells, and the challenge has <i>always</i> been "how can we ONLY kill the cancer?" We've been burning cancer, cutting cancer out, and drugging cancer cells for decades or centuries depending on the method. What is changing is not the type of challenge, but the precision of our tools - and even then, it remains to be seen if we actually <i>can</i> get the precision while improving the lives of the patients.</p>
]]></description><pubDate>Fri, 12 Jun 2026 21:37:28 +0000</pubDate><link>https://news.ycombinator.com/item?id=48509712</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48509712</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48509712</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Claude Fable is relentlessly proactive"]]></title><description><![CDATA[
<p>What are you on about? May be 1 out of 100,000 users are using 5.5 Pro to make 10 "Long Documents" as defined in that tool EVERY day. What a silly thing to harp on.<p>Six 100,000 token Claude coding sessions use less energy than a dryer load, and less water than making <i>one egg</i>. If you are truly concerned about energy and water usage, AI is not even in the top 100 things you should be concerned about in your daily life.</p>
]]></description><pubDate>Fri, 12 Jun 2026 12:25:01 +0000</pubDate><link>https://news.ycombinator.com/item?id=48503246</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48503246</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48503246</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Claude Fable 5"]]></title><description><![CDATA[
<p>The Startup Who Cried Unsafe, by AIsop</p>
]]></description><pubDate>Tue, 09 Jun 2026 18:57:12 +0000</pubDate><link>https://news.ycombinator.com/item?id=48465856</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48465856</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48465856</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Failing grades soar with AI usage, dwindling math skills in Berkeley CS classes"]]></title><description><![CDATA[
<p>When left to their own devices, 99% of children are not interested enough in math, history, literature, languages, or almost any other school subject to engage with it willingly. Only teaching "interesting" things that kids are "interested" in is both impossible (too many varied kids per class for that to work 100% of the time) and even if possible, would leave kids with zero practical knowledge, because learning most of that stuff is not something kids inherently want to do.<p>College is different, because theoretically you should be taking classes that are relevant to your field (although there are still "core" requirements that are somewhat high-school adjacent).</p>
]]></description><pubDate>Thu, 04 Jun 2026 11:47:51 +0000</pubDate><link>https://news.ycombinator.com/item?id=48397308</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48397308</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48397308</guid></item><item><title><![CDATA[New comment by TaupeRanger in "I was recently diagnosed with anti-NMDA receptor encephalitis"]]></title><description><![CDATA[
<p>Right. For every example of a doctor missing a diagnosis, there 100 examples of that doctor correctly telling people that they are likely suffering from a temporary condition that will work itself out or not be resolved by any further testing or medicine.</p>
]]></description><pubDate>Wed, 03 Jun 2026 21:04:59 +0000</pubDate><link>https://news.ycombinator.com/item?id=48390022</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48390022</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48390022</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Can the stockmarket swallow Anthropic, SpaceX and OpenAI?"]]></title><description><![CDATA[
<p>If what you say is true and it predicts the future, then everyone would be selling right now. The fact is, no one knows when or if the bubble will pop, and we will only be able to say in hindsight whether your comparison is correct.</p>
]]></description><pubDate>Tue, 02 Jun 2026 13:53:28 +0000</pubDate><link>https://news.ycombinator.com/item?id=48370285</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48370285</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48370285</guid></item><item><title><![CDATA[New comment by TaupeRanger in "DuckDuckGo makes its 'no-AI' search engine easier to access as its traffic booms"]]></title><description><![CDATA[
<p>The only delusion here is your comment. Claude and ChatGPT are extremely popular across millions of active daily users.</p>
]]></description><pubDate>Mon, 01 Jun 2026 16:55:49 +0000</pubDate><link>https://news.ycombinator.com/item?id=48359433</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48359433</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48359433</guid></item><item><title><![CDATA[New comment by TaupeRanger in "To have a moral stance on AI is to be an outcast, and it sucks"]]></title><description><![CDATA[
<p>Nuance would make the points stronger, not weaker. If you complain about something while assuming everyone should agree with you without question, you are not contributing to the conversation, but merely whining.</p>
]]></description><pubDate>Sun, 31 May 2026 12:40:17 +0000</pubDate><link>https://news.ycombinator.com/item?id=48345242</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48345242</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48345242</guid></item><item><title><![CDATA[New comment by TaupeRanger in "To have a moral stance on AI is to be an outcast, and it sucks"]]></title><description><![CDATA[
<p>It's part of this nihilistic undercurrent, especially among Millennials and younger generations. "I'm not having kids, have you seen the world?" "I'm not saving for retirement, Social Security won't exist and the oceans will swallow the continent by the time I reach retirement age." "I refuse to use AI tools that could help me create new things and reach my goals, because the influencers told me AI is going to poison the water". Quite sad actually.</p>
]]></description><pubDate>Sat, 30 May 2026 17:12:49 +0000</pubDate><link>https://news.ycombinator.com/item?id=48338530</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48338530</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48338530</guid></item><item><title><![CDATA[New comment by TaupeRanger in "To have a moral stance on AI is to be an outcast, and it sucks"]]></title><description><![CDATA[
<p>The post links to a pretty silly article with checkboxes about "accepting" certain  "facts" about AI, which the author says they resonated with:<p>> I accept the models were trained on stolen data.<p>"Stolen" is a moral stance that not everyone agrees with.<p>> I accept that the data was labeled by exploited workers.<p>Yes - and you just ordered DoorDash, which delivered food made by exploited workers and delivered by exploited workers. In fact, almost every convenience you enjoy is the result of some level of exploitation. That doesn't mean it's morally right, but if your outrage is pointed at GenAI (one of the technologies that can potentially level the playing field and <i>remove</i> some amount of exploitation) at the exclusion of these other things, you are simply rage farming.<p>> I accept the environmental costs of the data centers running these models.<p>No, they are totally overblown, and if you actually cared about any of these environmental issues, you would realize that data centers are not even in the top 100 things to be concerned about: <a href="https://blog.andymasley.com/p/the-ai-water-issue-is-fake" rel="nofollow">https://blog.andymasley.com/p/the-ai-water-issue-is-fake</a><p>> I accept that I am outsourcing some of my skills to a company.<p>No, I am outsourcing boring grunt work and using my skills in more meaningful and exciting ways.<p>> I accept these companies don’t have a viable business model.<p>Yes, I accept that, and if they fail I'll use another company's models. This technology isn't going away - why as a consumer do you care if one of the providers goes out of business?<p>> I accept that I am granting more power to big tech and their vision for the world.<p>I suppose, but we all pretty much accepted that 20-30 years ago.<p>> I accept that I am granting more power to the United States.<p>I suppose, but we all pretty much accepted that 80 years ago.<p>> I accept that all this effort could have been spent elsewhere.<p>It's not clear to me yet that the effort was poorly spent - who knows where AI will go, and what great things might potentially come from it?</p>
]]></description><pubDate>Sat, 30 May 2026 17:04:57 +0000</pubDate><link>https://news.ycombinator.com/item?id=48338444</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48338444</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48338444</guid></item><item><title><![CDATA[New comment by TaupeRanger in "What are locusts and what happened to them?"]]></title><description><![CDATA[
<p>One locust is an interesting bug. Billions of locusts are an apocalyptic nightmare.</p>
]]></description><pubDate>Sat, 30 May 2026 14:16:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=48336464</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48336464</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48336464</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Five frontier LLMs disagree on 67% of 1k real-world fact-check claims"]]></title><description><![CDATA[
<p>but that's without internet search - everyone I know uses the models that search when they need to, and I'm sure GPT and Opus would agree on almost everything if 1) they searched when necessary, and 2) they were allowed to give context to their answers instead of being hamstrung to get specious "research" results.</p>
]]></description><pubDate>Thu, 28 May 2026 14:15:43 +0000</pubDate><link>https://news.ycombinator.com/item?id=48309264</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48309264</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48309264</guid></item><item><title><![CDATA[New comment by TaupeRanger in "Disagreement Among Frontier LLMs on Real-World Fact-Checks"]]></title><description><![CDATA[
<p>What are you talking about? The models were not ALLOWED to have confidence (or the lack thereof). They were explicitly told to give a single label, and in most cases, all of them were correct depending on additional context they would surely have provided, especially with access to the internet (which some didn't have). This is just silly.</p>
]]></description><pubDate>Thu, 28 May 2026 14:07:13 +0000</pubDate><link>https://news.ycombinator.com/item?id=48309156</link><dc:creator>TaupeRanger</dc:creator><comments>https://news.ycombinator.com/item?id=48309156</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48309156</guid></item></channel></rss>