Hacker News: The_rationalist

New comment by The_rationalist in "GraalVM 22.1: Developer experience improvements, Apple Silicon builds, and more"

The_rationalist — Tue, 26 Apr 2022 16:38:32 +0000

yes shopify runs on truffleruby. It is the fastest ruby VM by far and can seamlessly call state of the art Java libraries. GraalVM is the VM to rule them all and unify currently incompatible billions of dollars libraries ecosystems. Despite being the computer science breakthrough of the decade, people are not getting it yet.

New comment by The_rationalist in "Why is inflammation a dangerous necessity?"

The_rationalist — Fri, 22 Apr 2022 01:56:28 +0000

I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.

New comment by The_rationalist in "Why is inflammation a dangerous necessity?"

The_rationalist — Thu, 21 Apr 2022 22:38:39 +0000

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

New comment by The_rationalist in "Gallium OS: a fast and lightweight Linux distro for ChromeOS devices"

The_rationalist — Thu, 14 Apr 2022 12:47:39 +0000

Why a dedicated distro, can't you use any distro on a chromebook?

New comment by The_rationalist in "86Box: Why Not Pentium III?"

The_rationalist — Fri, 08 Apr 2022 16:11:24 +0000

Should does not equal must. Wanting a better world with less suffering and more joy is not the same thing as imposing this world by force. A thought that should have occured to you.

New comment by The_rationalist in "86Box: Why Not Pentium III?"

The_rationalist — Fri, 08 Apr 2022 15:13:17 +0000

Well that makes pcem and x86box very niche then.. What should people actually use for emulating a recent x86 cpu like found on the PS4/PS5/xbox serie x and get good performance? Because this is where the human resources should be allocated, for enabling the support of hundreds of video games including major console exclusives

New comment by The_rationalist in "86Box: Why Not Pentium III?"

The_rationalist — Fri, 08 Apr 2022 13:34:04 +0000

I don't understand,the yuzu (switch) emulator has excellent performance and correctness. It perfectly emulate a modern ARM cpus at multiple GHz and properly emulate the Tegra Nvidia GPU.

Why would emulating x86 be so much harder, especially since you can actually use the host x86 cpu... via hardware hyoervisors e.g. https://github.com/intel/haxm

New comment by The_rationalist in "ACM Opens First 50 Years Backfile"

The_rationalist — Thu, 07 Apr 2022 21:44:52 +0000

This is big

New comment by The_rationalist in "Dall-E 2"

The_rationalist — Wed, 06 Apr 2022 17:01:59 +0000

Thank you narrative voice

New comment by The_rationalist in "Ask HN: Beating depression with or without anti-depressants?"

The_rationalist — Tue, 05 Apr 2022 23:52:50 +0000

MAOIs are not necessarily more dangerous, they just need a low tyramine diet which is easily doable. Moreover you can significantly lower this need with a concommitant NRI. transdermal (emsam) or selective mao-a or b don't even need a diet and are safer than SSRIs (no PSSD)

New comment by The_rationalist in "Ask HN: Beating depression with or without anti-depressants?"

The_rationalist — Tue, 05 Apr 2022 23:48:35 +0000

> Anti-depressants, if dosed and chosen properly, have basically no side effects WTF is that bullshit ? SSRIs destroy libido and possibly permanently (see r/pssd) MAOIs have many side effects NRIs are not effective NDRIs can cause tinnitus. Stims are cardiotoxic and usually not prescribed for depression. TCAs are not an action mechanism and therefore fall in the above categories. Atypical mechanisms are not better either. The only ones with low side effects either cause some sedation (mirtazapine, agomelatine) or have dubious effectiveness. The only one that stands out is moclobemide and maybe bifemelane. The latter is only available in japan. The former has low efficacy. hence for someone that don't want side effects, only moclobemide make sense, or ultra atypical stuff that has probably low efficacy. One of the only atypical that might be potent is SAM-e but who wants to play with his DNA methylation ? 9 mebc is phototoxic unfortunately as it is very promising otherwise. edit: it's true though that testosterone is apparently as effective as SSRIs and with less side effects.

What should be said though is that there are some great anxiolytic out there, it's just that no one knows them, e.g opipramol, emoxypine, etifoxine

New comment by The_rationalist in "Pathways Language Model (PaLM): Scaling to 540B parameters"

The_rationalist — Tue, 05 Apr 2022 15:37:44 +0000

if you can just get the model to answer the question you actually care about? LOL your level of optimism is over 9000. Language models are shit, they regularly utter nonsense and have an impressive number of limitations (e.g. no continual learning). A neuro-symbolic system on the other hand can be incrementally improved upon, has continual learning/a memory, and is interpretable.

New comment by The_rationalist in "Father-Son Team Solves Geometry Problem with Infinite Folds"

The_rationalist — Tue, 05 Apr 2022 13:23:34 +0000

life goals

New comment by The_rationalist in "Pathways Language Model (PaLM): Scaling to 540B parameters"

The_rationalist — Tue, 05 Apr 2022 01:06:08 +0000

You could technically dynamically offload the RAM overload to disk but this would probably be too slow?

New comment by The_rationalist in "Pathways Language Model (PaLM): Scaling to 540B parameters"

The_rationalist — Mon, 04 Apr 2022 21:24:10 +0000

not a single super large language model has beaten the state of the art in the key NLP tasks (POS tag, dep tag, coreference, wsd, ner, etc) They are always only used for higher level tasks, which is tragic.

New comment by The_rationalist in "Covid spike protein induces cognitive deficit and anxiety-like behavior in mice"

The_rationalist — Sun, 03 Apr 2022 23:00:00 +0000

Nearly all of it ends up in the lymph nodes near your armpit

Source needed.

New comment by The_rationalist in "Lifetime Annotations for C++"

The_rationalist — Sun, 03 Apr 2022 00:50:58 +0000

haha C++ lifetimes go brrr

New comment by The_rationalist in "Pointer Tagging for x86 Systems"

The_rationalist — Thu, 31 Mar 2022 23:16:22 +0000

https://llvm.org/docs/tutorial/BuildingAJIT1.html

New comment by The_rationalist in "The Uselessness of Phenylephrine"

The_rationalist — Wed, 30 Mar 2022 19:21:09 +0000

btw racemic meth is legally prescribed for ADHD under the brand desoxyn, although it's probably hard to find doctors prescribing it over regular amph

New comment by The_rationalist in "The Uselessness of Phenylephrine"

The_rationalist — Wed, 30 Mar 2022 17:54:23 +0000

Levo-methamphetamine is a legal decongestant BTW