<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: alpineidyll3</title><link>https://news.ycombinator.com/user?id=alpineidyll3</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Mon, 17 Aug 2026 08:54:31 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=alpineidyll3" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by alpineidyll3 in "AI in drug discovery – what it is, where we stand and the path forward"]]></title><description><![CDATA[
<p>if you think the state of the art in this area is something you'll hear about from a guy that looks like santa in an academic journal, your investments deserve what's about to happen to them.</p>
]]></description><pubDate>Sat, 15 Aug 2026 20:02:41 +0000</pubDate><link>https://news.ycombinator.com/item?id=49313804</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=49313804</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49313804</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "AI in drug discovery – what it is, where we stand and the path forward"]]></title><description><![CDATA[
<p>Absci has a good asset coming out pretty soon that you could try to get on the trial.</p>
]]></description><pubDate>Sat, 15 Aug 2026 20:02:00 +0000</pubDate><link>https://news.ycombinator.com/item?id=49313797</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=49313797</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49313797</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "AI Can Now Design Functional Viruses. Should We Worry?"]]></title><description><![CDATA[
<p>The sun is an existential threat. It will envelop earth in a few billion years, are you going to shut it off too?</p>
]]></description><pubDate>Sat, 15 Aug 2026 19:51:55 +0000</pubDate><link>https://news.ycombinator.com/item?id=49313719</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=49313719</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49313719</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "AI Can Now Design Functional Viruses. Should We Worry?"]]></title><description><![CDATA[
<p>This happened a full year ago. 
A) you should immediately discount the expertise of people just learning this now
B) a designed pathogen will kill a person this century, full stop, no way to prevent that. The people who invented fission were not so stupid they imagined the bomb wouldn't occur, indeed they assumed it would. I have no idea what became of the wisdom of those people. 
C) just like nuclear technology that doesn't mean a prohibition is called for. Intelligence is.<p>What we _can_ do is invest in detection, rapid response technology (vaccines etc), and attempt to mitigate and stratify the possibilities of this happening in the worse ways.<p>Today's knee jerk prohibitions, and fanciful notions of prohibition working are not facilitating those changes.</p>
]]></description><pubDate>Sat, 15 Aug 2026 19:50:37 +0000</pubDate><link>https://news.ycombinator.com/item?id=49313707</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=49313707</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49313707</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Spin audit of SQD/QSCI quantum-chemistry benchmarks on iron–sulfur clusters"]]></title><description><![CDATA[
<p>Quantum chemistry ex faculty member here who left for industry: OP is 100% correct to call out this BS and this preprint is just another attempt to abuse real science to promote a failing business experiment.<p>Because you can view today's error prone QCs as analog emulators of other quantum systems without solving error correction, often people reach to such "simulations". Google is equally guilty. Unfortunately most materials you touch reflect the behavior of electrons which are indistinguishable fermions. Their interactions are long ranged and maintain quantum correlations with all the electrons within the screening length. The spins of a flux qubit are distinguishable, and the pattern of connectivity in existing chips limit direct interactions to a handful of such qubits. Both these differences can be emulated away but at nonlinear cost. Ie even for this toy case there is no advantage . The entire thing is a fugazi. Once you also lump in the basis sets needed to make a realistic simulation and the fact that relativity is needed to describe this complex, the simulation might as well be comparing Looney tunes physics to Newton's principia.<p>When I was a postdoc with Alan people were playing these same games, making the same claims the same way. Even without the required 4 years of grad physics to understand what's happening a smart person could see the lack of impact over decades and reason this is BS.<p>But the play works to raise more money than you can make as faculty or a software dev, so people will keep running this play, perhaps until Google tires of it. It's not that making better quantum computers is stupid we should invest in the hardware dev, but not at the expense of science and truth.</p>
]]></description><pubDate>Fri, 07 Aug 2026 00:13:16 +0000</pubDate><link>https://news.ycombinator.com/item?id=49204406</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=49204406</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49204406</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Google details new 24-hour process to sideload unverified Android apps"]]></title><description><![CDATA[
<p>Honestly many people (including myself) still have the ability to unplug from this stuff, and so I think it's time to do that.</p>
]]></description><pubDate>Sat, 21 Mar 2026 03:44:46 +0000</pubDate><link>https://news.ycombinator.com/item?id=47463782</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=47463782</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47463782</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Google details new 24-hour process to sideload unverified Android apps"]]></title><description><![CDATA[
<p>I actually was kinda looking for a reason to give up phones. 
Thanks google.</p>
]]></description><pubDate>Sat, 21 Mar 2026 03:43:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=47463778</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=47463778</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47463778</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Is particle physics dead, dying, or just hard?"]]></title><description><![CDATA[
<p>But.. are you saying your vector coupling isn't explained by the existing standard model, that the measurement lacked sufficient resolution, or that existing calculations don't agree with your measurement?</p>
]]></description><pubDate>Wed, 11 Feb 2026 14:13:54 +0000</pubDate><link>https://news.ycombinator.com/item?id=46975163</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=46975163</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46975163</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Always be ready to leave (even if you never do)"]]></title><description><![CDATA[
<p>The author left out the most important detail:<p>- Before being ready to leave, make sure you either have, or will have, another opportunity or no need for an employer. VERY often (especially in tech!) employers/managers will have employees, not for their labor, but for vanity, to build a pyramid to themselves, or for image reasons. Such people will immediately send you packing for complaining about non-productivity. Your perception of your superior's alignment can easily be wrong.<p>Given that precondition... I agree with the premise.</p>
]]></description><pubDate>Sat, 08 Nov 2025 20:04:30 +0000</pubDate><link>https://news.ycombinator.com/item?id=45859523</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=45859523</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45859523</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "U.S. Flights Are Canceled as Shutdown Hits Air Travel"]]></title><description><![CDATA[
<p>The last time this guy was president people were locked inside and schools didn't work.  A reasonable prior is that this airline thing (which did affect me) isn't the end.</p>
]]></description><pubDate>Fri, 07 Nov 2025 23:03:16 +0000</pubDate><link>https://news.ycombinator.com/item?id=45852309</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=45852309</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45852309</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Against "Against Life Extension""]]></title><description><![CDATA[
<p>People love to have opinions about how technologies should develop, but time and again, market realities are what guide their development. People easily get emotional about life extension, and it grabs a lot of attention because of that, but all those feelings don't measure up to the impossible to extrapolate tertiary effects of any technology which transforms lives, life extension definitely being one.<p>I'd argue that it's pretty clear that lipitor is partially to blame for our present gerontocracy muddle, but the issue there is that lipitor transfers mortality from the heart to many other conditions, some of which impair thinking. Life extension isn't a monolith, nor are the mechanisms of cellular age in animals. It's a blanket for 1000s of possible technologies. Productive conversations about it would be nuanced, and related to details about a particular  technology, which these conversations never seem to rise to the level of. Definitely not this piece or fukuyama's either.<p>I come to HN for nuance.</p>
]]></description><pubDate>Wed, 04 Jun 2025 15:38:21 +0000</pubDate><link>https://news.ycombinator.com/item?id=44181917</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=44181917</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44181917</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Netflix's Media Production Suite"]]></title><description><![CDATA[
<p>This is exactly how I'd imagine the dreck on netflix is made :).</p>
]]></description><pubDate>Tue, 01 Apr 2025 01:46:57 +0000</pubDate><link>https://news.ycombinator.com/item?id=43542002</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=43542002</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=43542002</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "US health system ranks last compared with peer nations – report"]]></title><description><![CDATA[
<p>The US likes to pretend free markets are our principle, but we have completely destroyed every notion of a free two-sided market on healthcare. That's the simple explanation for our outcome.</p>
]]></description><pubDate>Fri, 20 Sep 2024 03:10:02 +0000</pubDate><link>https://news.ycombinator.com/item?id=41598445</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=41598445</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=41598445</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Launch HN: Roe AI (YC W24) – AI-powered data warehouse to query multimodal data"]]></title><description><![CDATA[
<p>I am glad to see people focusing on this.<p>If this tool could parse drug patents and draw molecular structures with associated data, I know we would pay 200k/yr+ for that service, and there's a market for it.<p>In my own field, there's an incredibly important application to parse patents and scientific papers, but this would require specific image=>text models in order to get the required information out with high fidelity. Do you guys have plans to enable user supplied workflows where perhaps image patches can be sent to bespoke encoders, or finetunes?</p>
]]></description><pubDate>Sun, 11 Aug 2024 17:45:44 +0000</pubDate><link>https://news.ycombinator.com/item?id=41217938</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=41217938</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=41217938</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Klarna says its AI assistant does the work of 700 people"]]></title><description><![CDATA[
<p>This from the company I had to call all my banks to refuse charges from because they harbor rampant fraud.</p>
]]></description><pubDate>Sat, 02 Mar 2024 03:47:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=39569621</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=39569621</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=39569621</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Open-relationship enthusiasts crash mainstream romance apps"]]></title><description><![CDATA[
<p>Human beings are naturally envious and covetous creatures. Everyone loves to talk about other people's love lives, and maintains strong opinions about how they should be, while paradoxically relating to the fact that love makes fools of us all.<p>Meanwhile journalists rest more and more on sexual politics to elicit interest in a public who is very tired of what they have to say.<p>How about we build stuff, and let people worry about their own love lives?</p>
]]></description><pubDate>Fri, 19 Jan 2024 20:35:33 +0000</pubDate><link>https://news.ycombinator.com/item?id=39060763</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=39060763</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=39060763</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Peer review is an honor-based system (2008)"]]></title><description><![CDATA[
<p>If people would actually _measure_ the outcomes of peer review instead of talking about it, I think it would meet a swift end.<p>Empirically, I find no improvement in reproducibility between arxiv and journals. The costs are incredibly high too.<p>Like many things in our world peer review is a short lived extrapolation which doesn't resemble it's origins but is regarded as immutable gospel. It matters most if what you need is the respect of academics.</p>
]]></description><pubDate>Sat, 13 Jan 2024 21:16:09 +0000</pubDate><link>https://news.ycombinator.com/item?id=38984658</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=38984658</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=38984658</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Posters Promoting Illegal Drug Use Pop Up in Downtown San Francisco"]]></title><description><![CDATA[
<p>Sure, this may be the perspective of an individual suffering from a mental dependence on a dangerous mind-altering substance, but it deserves equal consideration. (/sarcasm)<p>Unfortunately, I don't think it's this type of visible but marginal nonsense which perpetuates the SF drug economy. There are simply a lot of people making money on the blight. Private equity funds have piled into methadone treatment, even though other treatments are more evidence-based. No matter the customers are penniless wretches, the government is billed astronomical sums to perpetuate their suffering. These are some of the highest profit margin balance sheets I've ever seen. A public which lacks the stomach to account for whether remediations are evidence-based, collaborates with the cartels to keep the whole thing spinning and shambling.<p>Walk into any hospital waiting room, and count the dollars disappear to "treat" the dopesickness of a victim. Like the rest of the US healthcare system, it's a galactic obvious grift enabled by regulatory capture, operating in plain sight.</p>
]]></description><pubDate>Fri, 05 Jan 2024 19:33:50 +0000</pubDate><link>https://news.ycombinator.com/item?id=38883633</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=38883633</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=38883633</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Important People Are Noticing How Terrible Clear Is for Airports"]]></title><description><![CDATA[
<p>Yes. Before criticizing an efficient solution merely because it has a cost we must explain why the non market solution is a farce of inefficient security theatre.<p>Private flights have no security whatsoever. They are also much more climate unfriendly. If commercial becomes more of a headache people will press up towards jetshares...</p>
]]></description><pubDate>Thu, 28 Dec 2023 06:37:43 +0000</pubDate><link>https://news.ycombinator.com/item?id=38790711</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=38790711</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=38790711</guid></item><item><title><![CDATA[New comment by alpineidyll3 in "Klarna freezes hiring as chief bets AI can do the job instead"]]></title><description><![CDATA[
<p>This company is such trash. I had to call all my financial institutions and prevent any klarna charges because of how they enable fraud.</p>
]]></description><pubDate>Wed, 06 Dec 2023 01:06:31 +0000</pubDate><link>https://news.ycombinator.com/item?id=38539242</link><dc:creator>alpineidyll3</dc:creator><comments>https://news.ycombinator.com/item?id=38539242</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=38539242</guid></item></channel></rss>