A cell is a bundle of proteins wrapped in a membrane that's sort of an oil drop (or as another comment said, a fat bubble). In biology it's called a phospholipid bilayer. Fun fact you can actually "merge" cells together with the help of certain viruses. Drug delivery usually involves moving molecules though this phospholipid bilayer which involves all sorts of tricks. There are pores and receptors on the membrane that can selectively bind to different biochemical molecules and proteins. A good chunk of research in bioinformatics, chemoinformatics, quantum computing is focusing on simulating protein binding dynamics and protein-protein interactions on various levels so we can design drugs that can bind to the receptors we want. (Alphafold made this a lot easier to figure out how to go from a sequence of genetic material to a specific protein shape) A RNA vaccine is kinda like a virus in that it has to be taken into a so the cellular machinery (ribosomes) can build the protein that it codes for. So having a micelle (or nanoparticle, whatever you want to call it) that can get absorbed and merged into the cell that you are targeting specifically is a Big Deal.

Virology based methods don't last very long because the immune system adapts quickly. If you want to go down that route, make sure you have experts on hand.

The explanation doesn't get much better at higher levels. You have the Krebs cycle which biology people religiously memorize but it doesn't really explain much either. The actual interesting part is usually handwaved away as "magical enzyme/protein" catalysis. Understanding how the mitochondrial proteins/enzyme catalysts function would usually require a graduate degree, and maybe a background in biochemistry and biophysics.

Biology is a leaky abstraction, it's very hard to do anything with rigor without having a strong foundation in the fundamentals. You see the same discussion on hacker news when it comes to music, people are more interested in mapping programming concepts to music notation and complaining about western music presentation than the music itself. For biology, you need need to have a firm understanding of the central dogma and biochemistry if you want to do anything beyond surface level empirical trial and error. Most people, especially the "hacker types", only have a vague understanding of the former i.e. DNA translation and transcription and that's about the limit. You absolutely have to gain an intuition for biochemistry if you want to do things with rigor, otherwise you will just be the biotech equivalent of a bootcamp web developer, fit for washing test tubes and not much else.

> A multicellular organism gametes divide only a handfull of times per generation.

That's what recombination is for during sexual reproduction.

> It does not contain informtion how to assemble the molecular machines from the proteins, or how "to be alive" in general.

Unless you subscribe to the creationist or Larmarckian schools of thought, this is flat out wrong. DNA polymerase and similar analogues like reverse transcriptase do not exist in a vacuum. There are entire branches of evolutionary biology dedicated to studying their formation. The main transcription proteins, helicase, polymerase, and ribosomes can all be assembled from the basic proteins they themselves transcribe. (Incidentally figuring out the ultimate structure that a protein chain assembles into is what AlphaFold does, bioinformatics and ML's crowning jewel)

> There is heritable information outside of DNA, that is epigenetic in its nature.

When biologists refer to epigenetics, they mean information carriage that's not strictly tied to the nucleotides. This doesn't meant DNA isn't involved. Most epigenetics I can think of off the top of my head all involve the DNA transcription mechanism in some way.

This is very much true. I find that a lot of people in tech seem to put healthcare on a pedestal and believe that the professionalisation and gatekeeping of the industry create a better outcome than other engineering fields. This is very much untrue, the healthcare field is in need of massive disruption and lobbying to increase labor supply. You are being downvoted because a lot of tech people here hate to imagine that healthcare at the highest level is still subject to market forces like everything else. Medical training is being severely gatekept and hindered via the current apprenticeship/residency system. After all, we call the worst medical student, doctor. If you want to improve healthcare, tie medical school admission to the MCAT score, and only the MCAT score. You are not going to get better doctors just because candidates spend their summers building houses in some impoverished third world country.

https://github.com/xmake-io/xmake#supported-package-reposito...