Hacker News: anonymous391084

New comment by anonymous391084 in "Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s"

anonymous391084 — Thu, 03 Sep 2026 04:40:57 +0000

I respect the regulatory arbitrage, but for example Uber and Airbnb both arguably had pretty revolutionary tech layers on top of that. Trying to figure out what the equivalent here is.

New comment by anonymous391084 in "Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s"

anonymous391084 — Thu, 03 Sep 2026 02:53:28 +0000

I guess I'm trying to figure out what the secret sauce is that makes this a YC company, there are at least dozens, probably hundreds of telehealth GLP prescribers, manufacturing it yourself doesn't really seem like a value-add, all of them will compound with B12 for the reasons you mention elsewhere, it's hard to believe that "tell your doctor you're having side effects and they will adjust your dose" is a YC-worthy innovation. What am I missing?

New comment by anonymous391084 in "Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s"

anonymous391084 — Wed, 02 Sep 2026 23:59:53 +0000

I think most people on gray market GLPs will vary their dose, take tolerance breaks, etc to meet their personal weight loss goals, this stuff isn't that complicated. Where I think where the real technology opportunity is, is having a personalized endocrinologist for TRT/HRT. Bodybuilders have incredibly sophisticated trackers with hormone/ester PK models and the ability to adjust and tune your personal model based on bloodwork results. Most men's clinic, online or in person, are nowhere near as advanced. Prescribing for most of these guys is binary, or adjusting your dose is something that's done in response to some sort of a problem like hematocrit or gyno, rather than trying to keep levels in-line with whatever health goal you have. I don't think most guys really need the full TRT dose of 140 mg/week to feel energetic again, but depending on your fitness goals you can go well beyond that safely as long as you are paying close attention. There have been a couple of "high tech HRT" apps but I don't think they are really all that sophisticated, maybe daily dosing or includes a tasso device or whatever, but nothing afaik with multi-hormone PK modeling and testing feedback, so it could be right up your alley.