Hacker News: anotherboffin

New comment by anotherboffin in "Cancel Your Subscription: a free browser game"

anotherboffin — Fri, 02 Oct 2026 19:28:25 +0000

Was a good mix of funny and frustrating here. Adding input lag would definitely have made it infuriating.

New comment by anotherboffin in "Why some US restaurants are banning tips"

anotherboffin — Tue, 25 Aug 2026 11:48:01 +0000

Not the OP, but I guess they meant non-Swiss as someone who might be used to a different set of tipping norms?

New comment by anotherboffin in "Claude Code is leaking real email address as a User-Agent string in curl command"

anotherboffin — Tue, 11 Aug 2026 14:49:22 +0000

Any good pointers on how/where to get started?

New comment by anotherboffin in "The only road in London where you have to drive on the right"

anotherboffin — Wed, 29 Jul 2026 12:04:04 +0000

Oof that looks brutal

New comment by anotherboffin in "Every part on a bicycle is safety critical"

anotherboffin — Sun, 20 Jul 2025 10:34:19 +0000

He’s a cycling journalist (specialized in tech), not a shop owner.

New comment by anotherboffin in "Every part on a bicycle is safety critical"

anotherboffin — Sun, 20 Jul 2025 10:33:15 +0000

Just to add some context: e-bike commuters in a hilly city would go through the stock organic brake pads in <500 km sometimes. Could be as little as 6 weeks. The shop I worked at (back in the day) would replace them with longer wearing third-party pads.

New comment by anotherboffin in "Things I Won't Work With: Dioxygen Difluoride (2010)"

anotherboffin — Tue, 01 Apr 2025 13:10:11 +0000

Good point! I’ll be more careful before quick posting.

New comment by anotherboffin in "Things I Won't Work With: Dioxygen Difluoride (2010)"

anotherboffin — Tue, 01 Apr 2025 06:49:31 +0000

Yeah, I suspect “Melissa” fed Lowe’s article to an LLM to get a quick article that’s sure to get views.

New comment by anotherboffin in "Tesla drives into Wile E. Coyote fake road wall in camera vs. Lidar test"

anotherboffin — Sun, 16 Mar 2025 21:18:16 +0000

Oh but no worries, FSD is a “solved problem” and should be done in 18 months or so…

New comment by anotherboffin in "Google Pixel 4a's old firmware is gone, trapping users on buggy battery update"

anotherboffin — Fri, 31 Jan 2025 07:34:08 +0000

They didn’t offer free repairs, but they also didn’t limit it to five countries.

New comment by anotherboffin in "Ask HN: Who is hiring? (November 2024)"

anotherboffin — Sat, 02 Nov 2024 18:40:24 +0000

Not an applicant, but thanks for your app!

New comment by anotherboffin in "Galaxy Buds reportedly exploded in a user's ear causing permanent hearing loss"

anotherboffin — Thu, 26 Sep 2024 07:15:09 +0000

I enjoy using both, but you’re leaving out microphonics (especially on zippers), cable tangle and getting frayed/damaged/caught on clothing, just to name a few.

New comment by anotherboffin in "Apple Watch sleep apnea detection gets FDA approval"

anotherboffin — Mon, 16 Sep 2024 18:15:27 +0000

I’m on Garmin watches as well but this line of thinking is getting old. Partner has an Apple Watch and they charge it while in the shower/getting dressed and occasionally 10-15 minutes in the evening to make sure it gets through the night. Charger is in a convenient location and it’s dead easy to drop the watch on it. If you’re running ultras, then by all means stay on Garmin. But honestly for the day to day I’ve rarely seen it be an issue.

ETA: there’s plenty of valid reasons to prefer other watches (ANT+ compatibility being one of mine) but honestly the battery life thing is really not that bad for most users.

New comment by anotherboffin in "iPhone 16 Pro lets users capture ProRAW photos in JPEG-XL format"

anotherboffin — Sat, 14 Sep 2024 10:28:32 +0000

I guess creativity and technical advancements take longer than the yearly upgrade cycle required by marketing.

New comment by anotherboffin in "Tour de France riders are inhaling carbon monoxide in 'super altitude' recipe"

anotherboffin — Fri, 12 Jul 2024 18:19:08 +0000

I had heard that in the context of absurdly high hematocrit, where they would get their heart rate up to move the (very viscous) blood around their body. No source, but doesn’t sound impossible when everyone was on EPO.

New comment by anotherboffin in "Relative Evaluation Report on S1, iPhone (2010) [pdf]"

anotherboffin — Wed, 12 Jun 2024 14:06:59 +0000

> […] it's still impossible to not have all your apps plastered on the home screen, at best in folders, is a mind boggling missing feature in iOS.

You didn’t even try looking, I just checked all the way back to iOS 14 and it was already possible. Yes, it doesn’t change your opinion, but undermines the point you’re making.

New comment by anotherboffin in "EpiPen For Heart Attacks? Idorsia Launches Phase III Study Of Selatogrel (2021)"

anotherboffin — Thu, 28 Mar 2024 18:40:11 +0000

If I remember correctly, part of the goal here is to gain a bit of time while the patient gets to the ER. I’m no expert but as you seem to have alluded to, the risk profile of alteplase/tenecteplase doesn’t seem to be well suited to an autoinjector with “if in doubt, use it and call the ambulance” instructions.

New comment by anotherboffin in "My cat water fountain comes with a spicy USB power adapter"

anotherboffin — Tue, 19 Dec 2023 18:34:01 +0000

Hypothetically, and just out of curiosity: if mint2 were to keep this email and it would be included as part of the evidence in a lawsuit, how would this bode for Lidl?

New comment by anotherboffin in "How Big Pharma reaps profits while hurting everyday Americans (2019)"

anotherboffin — Sat, 07 Oct 2023 18:34:07 +0000

Pretty close. Without getting into what is “cheaper and easier”, the work you need to do to publish is a bit different from the amount of work you need to do to: identify targets, set up screening assays, screen hundreds of thousands of compounds, find/optimize a hit, set up secondary assays, optimize the lead compound, do all kinds of physchem/tox/safety studies, select an indication, test in animal models if good ones exist, try and find a suitable dose range, and put all that into a package to support a phase 1 trial. This is part what I’ve seen on the biology side of things, and it only scratches the surface of what the chemistry (small-batch synthesis and the scale-up), pharmacology, and associated people contribute.

Lots of people can synthesize and test a compound in vitro. Doing the above is another challenge because it needs to work reliably in humans.

And yes, from my understanding, universities are getting better at patenting and licensing their IP. Some even do some basic drug discovery IIRC.

New comment by anotherboffin in "Oral cancer drug kills 100% of tumors in vitro and in animal models"

anotherboffin — Fri, 04 Aug 2023 19:26:00 +0000

Formulation is pretty important too. Do they give any detail on that?