Comments URL: https://news.ycombinator.com/item?id=46467192

Points: 2

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Clinical trials are designed to treat a very specific subclass of individuals; pharmaceutical companies very carefully choose that subclass in an attempt to help ensure the clinical trials are successful, which is a combination of the following:

- Positive, statistically-significant results. - FDA approval with those results. - Insurance companies willing to pay for the given treatment. - A decent-sized addressable market.

Examples of drugs/medical technologies later getting other indications: - Minoxidil was a drug that only later got its approval to be used as a hair loss treatment; there are currently clinical trials for a more "advanced" minoxidil oral pill for this use case. - Re: GLP-1s: Tirzepatide later got an indication that it effectively treats sleep apnea. There are very many other clinical trials ongoing for GLP-1s, but perhaps most recently, Semaglutide (ozempic) failed to show statistical significance as a treatment for Alzheimer's. - The Galleri blood screening/test. The initial indication they are going for is folk who are at highest risk for cancer (I believe that's individuals between the ages of 50 and 70); however, that's not to say it would be bad for individuals younger or older. But, this is a way to help ensure the earliest product has a successful outcome.

These are ones I know off the top of my head, but I suspect an LLM can give several more examples.

It didn't take very long to learn, and it turned out to be extremely important in the work I did during the early days at Waymo and later at Motional.

I wanted to pass along this fun video from several years ago that discusses HDR: https://www.youtube.com/watch?v=bkQJdaGGVM8 . It's short and fun, I recommend it to all HN readers.

Separately, if you want a more serious introduction to digital photography, I recommend the lectures by Marc Levoy from his Stanford course: https://www.youtube.com/watch?v=y7HrM-fk_Rc&list=PL8ungNrvUY... . I believe he runs his own group at Adobe now after leading a successful effort at Google making their pixel cameras the best in the industry for a couple of years. (And then everyone more-or-less caught up, just like with most tech improvements in the history of smartphones).

I believe that Turner probably did some great things, but somehow I don't think I believe he invented ray tracing. Ray tracing has been around for so long in physics...

Comments URL: https://news.ycombinator.com/item?id=18056182

Points: 1

# Comments: 0

You know how you've take a course before where the professor was just surprisingly awful at teaching? These professors are often some of the most knowledgeable people in a subfield of the subject you are taking, yet their teaching ability is severely lacking and you have to scramble to learn the material some other way (or just never learn it).

During a PhD, there is a decent chance that your adviser is similarly a bad manager. Unfortunately, having a bad manager for 5-7 years of your life can be a fairly awful experience. You will work with someone who you, on the one hand, look up to, but on the other hand, who seems to not care at all about your mental health, your possible career desires outside of academia, your work/life balance, or the exact reason why this week was a rough week for research in your (human) life.

I have a lot of other thoughts on the matter, but I thought I'd try to keep this post more concise =).

There's always more you might want to learn, but when people talk about these basics, it's really just being super focused in 4 or so classes, not a whole ivy league undergrad curriculum in math.

probability & stats, multivariable calculus, and linear algebra will take you a long way.

Has anyone had a professor that tried something like this?

=(. Sad.