Hacker News: automationwiz

New comment by automationwiz in "Claude designed protein binders against scorpion neurotoxins"

automationwiz — Wed, 21 Oct 2026 00:01:42 +0000

It was pretty grand not having to string together the bio-informatics and protein design pipeline and let Claude handle that and the environment. A lot of these tools in the past are fragmented and sometimes frozen to certain versions of a language which meant debugging. I didn't have to do at all; if there was env issues or GPU incompatibility Claude ran tests before execution and figured it all out for me. Truly the most boring stuff of this it fixed which would probably have made me give up if I was on my own.

New comment by automationwiz in "Claude designed protein binders against scorpion neurotoxins"

automationwiz — Tue, 20 Oct 2026 22:10:10 +0000

I did this at home with a 5090 on a different target a few weeks ago. Cannot generate 318,000 designs but Claude chose the nearly same tooling, except I used BindCraft2 which is better for multi target designs in the beginning. This isn't that special, its just doing tool calls. I got 100 or so trajectories running 24hrs just for fun.

"Throughout the process, Claude generated 318,484 protein designs and selected 180 of them for testing. Our team added 31 more, with Claude’s help."

"lab-tested all 211 designs to see if they would bind to the toxins they were designed against, and 17 designs met our criteria for a binder. "

Alright how many of those 17 were 100% Claude, I know mine were. These mini-proteins the tooling I'm told is pretty good for these. I'm worried that Claude might just choose the same tooling for everyone if this is the path we go down and designs stagnate?

New comment by automationwiz in "Previewing the Model Hardware Standard"

automationwiz — Thu, 27 Aug 2026 19:00:53 +0000

Sounds like PyLabRobot:

https://docs.pylabrobot.org/stable/

New comment by automationwiz in "'Turbocharged' Mitochondria Power Birds' Epic Migratory Journeys"

automationwiz — Wed, 21 May 2025 23:29:08 +0000

I don't want to rain on your parade but this was most likely not CFS. Chronic Fatigue Syndrome is diagnosed through the Canadian Consensus Criteria where Post Exertional Malaise is one of the defining factors. Where your body reacts to exercise or exertion 24h-48hrs later, not in the moment, but later. It also has to be going on greater than 6 months. CFS isn't "fatigue", its a bad name, it is a syndrome of symptoms.

New comment by automationwiz in "The April Fools joke that might have got me fired"

automationwiz — Tue, 01 Apr 2025 18:49:41 +0000

Thought I'd drop my prank as well. In highschool early 2011-2013ish QR codes were just becoming a thing. We had a mild vendetta against the year book committee due to the pricing of the yearbooks and their cliquey group.

We copied their "Reserve a year book early poster and save". Then used photoshop to edit it to say "50% off your year books with this QR code". The QR code then linked to a gorilla eating a taco (google this its pretty funny), adding to confusion. The year book committee had a FREAK out and sent out a mass email that the QR code was fake and not to follow it and you COULD NOT GET 50% off a year book no matter what link you followed. Needless to say sparked more interest in said QR code and soon the whole school had loaded a gif of a gorilla eating a taco.

New comment by automationwiz in "Japan pharma startup to begin human trials of tooth regrowth drug in 2024"

automationwiz — Tue, 26 Sep 2023 21:52:39 +0000

We growing teeth but still no hair