Hacker News: brandonb

Longitudinal Changes InWearable-Captured PhysiologyBefore Sudden Cardiac Death

brandonb — Wed, 28 Oct 2026 15:04:12 +0000

Article URL: https://www.jacc.org/doi/epdf/10.1016/j.jaccas.2026.110397

Comments URL: https://news.ycombinator.com/item?id=50274885

Points: 1

# Comments: 0

Vaccines for Cancer

brandonb — Tue, 27 Oct 2026 23:10:46 +0000

Article URL: https://jamanetwork.com/journals/jama/fullarticle/2854262?guestAccessKey=a0997df4-192d-410d-8c20-1ae3418a415d&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=etoc-tfl_&utm_term=102726

Comments URL: https://news.ycombinator.com/item?id=50267191

Points: 4

# Comments: 0

Slack's experience being acquired by Salesforce (part one)

brandonb — Sun, 25 Oct 2026 15:02:26 +0000

Article URL: https://buildingslack.com/salesforce-part-one/

Comments URL: https://news.ycombinator.com/item?id=50232264

Points: 1

# Comments: 0

Demis Hassabis shortens AGI timeline from five to two to three years

brandonb — Fri, 23 Oct 2026 01:23:47 +0000

Article URL: https://the-decoder.com/deepmind-founder-hassabis-shortens-agi-timeline-from-five-to-two-to-three-years/

Comments URL: https://news.ycombinator.com/item?id=50203385

Points: 3

# Comments: 3

New comment by brandonb in "AI analysis of CT scans finds 42.9% of patients have coronary inflammation"

brandonb — Thu, 22 Oct 2026 19:31:20 +0000

I'm curious-did you have any traditional risk factors (LDL/ApoB, blood pressure, HbA1c, hs-CRP, high PREVENT or ASCVD score)? Or put another way, did you ever find an underlying cause as to why you had a heart attack at age 29?

New comment by brandonb in "AI analysis of CT scans finds 42.9% of patients have coronary inflammation"

brandonb — Thu, 22 Oct 2026 19:15:56 +0000

This is one of the things that makes me a little skeptical of their score. If it's accurate, there should be a positive correlation with known biomarkers. (I see you made a similar observation elsewhere.)

In their paper they actually find an inverse correlation with hs-CRP, which disappeared when removing two patients who were sick. So I wonder if the sample size being small is partly driving this.

New comment by brandonb in "AI analysis of CT scans finds 42.9% of patients have coronary inflammation"

brandonb — Thu, 22 Oct 2026 19:09:23 +0000

Same thing happened with the Lp(a) drugs recently. Practically speaking, statins reduce LDL cholesterol (~50% at the strongest dose) and hs-CRP (~37%) and have cardiovascular outcomes data, so that's likely the route a patient would go based on the medications that are approved today.

New comment by brandonb in "AI analysis of CT scans finds 42.9% of patients have coronary inflammation"

brandonb — Thu, 22 Oct 2026 18:36:32 +0000

This particular study looked at inflammation through imaging (CT scans) as part of Biograph's $17,500 program. You can get at the underlying signal fairly cheaply through a simple blood test (hs-CRP).

It's fairly well-known that inflammation is an independent risk factor for heart disease, alongside LDL cholesterol (or ApoB) and blood pressure: https://www.empirical.health/blog/inflammation-and-heart-hea...

The American College of Cardiology looked at a bunch of inflammation biomarkers and standardized on hs-CRP: https://www.jacc.org/doi/10.1016/j.jacc.2025.08.047