Hacker News: carlsborg

New comment by carlsborg in "Acetaminophen vs. ibuprofen"

carlsborg — Wed, 22 Apr 2026 07:05:14 +0000

"since 2019, on the advice of the National Agency for the Safety of Medicines and Health Products, French health workers have been told not to treat fever or infections with ibuprofen." [1]

But yet in some countries pediatricians will libreally prescribe it to toddlers

[1] https://www.bmj.com/content/368/bmj.m1086

Also from [2] "In this systematic review of NSAID use during acute lower respiratory tract infections in adults, we found that the existing evidence for mortality, pleuro-pulmonary complications and rates of mechanical ventilation or organ failure is of extremely poor quality, very low certainty and should be interpreted with caution."

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.1451...

New comment by carlsborg in "AWS engineer reports PostgreSQL perf halved by Linux 7.0, fix may not be easy"

carlsborg — Sun, 05 Apr 2026 09:34:54 +0000

Perhaps in due time we will see workload specific forks of Linux maintained by a team of agents

New comment by carlsborg in "Telnyx package compromised on PyPI"

carlsborg — Fri, 27 Mar 2026 18:58:40 +0000

Anthropic/OpenAI could own this space. They should offer a paid service that offers a mirror with LLM scanned and sandbox-evaluated package with their next gen models. Free for individuals, orgs can subscribe to it.

New comment by carlsborg in "Autoresearch on an old research idea"

carlsborg — Mon, 23 Mar 2026 19:23:00 +0000

> “ The agent acted like a hyperparameter optimization algorithm with some basic reasoning baked in.”

Good lens.

The crux of the auto research repo is basically one file - program.md which is a system prompt that can be summarized as “do this in a loop: improve train.py, run the training, run evals, record result. Favor simplicity”. The other files are an arbitrary ML model that is being trained.

New comment by carlsborg in "The seven hour explosion nobody could explain"

carlsborg — Sat, 21 Mar 2026 20:53:36 +0000

3I/ATLAS first detected on: July 1 2025

Gamma ray burst that kept going for seven hours, fired three distinct bursts spread across an entire day: July 2 2025

just saying

New comment by carlsborg in "Montana passes Right to Compute act (2025)"

carlsborg — Sat, 14 Mar 2026 16:55:14 +0000

This is why Montana Civil Defense survives when skynet goes rogue.

New comment by carlsborg in "Unlocking Python's Cores:Energy Implications of Removing the GIL"

carlsborg — Mon, 09 Mar 2026 12:51:32 +0000

Should have funded the entire GIL-removal effort by selling carbon credits. Here's an industry waiting to happen: issue carbon credits for optimizing CPU and GPU resource usage in established libraries.

New comment by carlsborg in "Cognitive Debt: When Velocity Exceeds Comprehension"

carlsborg — Sat, 28 Feb 2026 17:57:43 +0000

The solution is ironically, LLMs. You can construct a set of Claude skills to walk you through a code review, or understand code (anything, even course) fast.

This complexity to understanding compression will be a big market going forward.

How Anthropic Teams use Claude Code [pdf]

carlsborg — Fri, 27 Feb 2026 03:56:05 +0000

Article URL: https://www-cdn.anthropic.com/58284b19e702b49db9302d5b6f135ad8871e7658.pdf

Comments URL: https://news.ycombinator.com/item?id=47176304

Points: 5

# Comments: 0

AMZN Q4 2025 Results and News Release

carlsborg — Thu, 05 Feb 2026 23:49:54 +0000

AWS Revenue: ~$35B (up 24% yoy, fastest growth in 13 quarters)

AWS Operating Income: ~$12B (up 17% yoy)

"AI, chips, robotics, and low earth orbit satellites: ..we expect to invest about $200 billion in capital expenditures across Amazon in 2026.."

This is eating into Free Cash Flow (FCF) which shows a downtrend over the last 5 quarters to ~$11B. In contrast MSFT free cashflow also down to ~$5B. (FCF = Operating cash flow - capex)

Custom chips: Trainium and Graviton now have a combined annual revenue run rate of over $10 billion and growing at a triple digit percentage year-over-year.

Lots of agent-related new releases in this quarter: Nova Act (for building AI agents for UI workflows); Amazon Bedrock AgentCore (infrastructure building blocks to build agents); "frontier agents" Kira, AWS Security Agent, AWS DevOps Agent; Agentic AI capabilities for Amazon Connect (call center platform)

Comments URL: https://news.ycombinator.com/item?id=46907127

Points: 1

# Comments: 0

Filtered back-projection algorithm (X Ray Tomography)

carlsborg — Thu, 22 Jan 2026 22:10:58 +0000

Article URL: https://www.youtube.com/watch?v=JLFhG3ddgTU

Comments URL: https://news.ycombinator.com/item?id=46725775

Points: 2

# Comments: 0

New comment by carlsborg in "Design Thinking Books (2024)"

carlsborg — Thu, 22 Jan 2026 13:08:36 +0000

I will add : "The Design of Design" by Fred Brooks (of The Mythical Man Month fame)

New comment by carlsborg in "Total monthly number of StackOverflow questions over time"

carlsborg — Sun, 04 Jan 2026 05:24:17 +0000

Acquired in June 2021 for $1.8 billion usd. Hurts but acquirer Naspers is a prolific tech investor, its stake in TenCent is worth > $150B usd today.

New comment by carlsborg in "It's Always TCP_NODELAY"

carlsborg — Tue, 23 Dec 2025 07:40:28 +0000

Unless you're cross platform on Windows too and then theres also a vast number of random registry settings.

New comment by carlsborg in "Ireland is making basic income for artists program permanent"

carlsborg — Wed, 15 Oct 2025 14:16:58 +0000

People should vote on art and if you hit a threshold, you get the income.

Mindstorms in Natural Language-Based Societies of Mind

carlsborg — Mon, 22 Sep 2025 06:28:34 +0000

Article URL: https://arxiv.org/abs/2305.17066

Comments URL: https://news.ycombinator.com/item?id=45329744

Points: 1

# Comments: 0

New comment by carlsborg in "Show HN: I recreated Windows XP as my portfolio"

carlsborg — Sun, 07 Sep 2025 02:16:40 +0000

Arguably the most familiar desktop user interface on the planet. I often wonder why complex web apps do not use this searchable start menu format.

New comment by carlsborg in "NASA's Webb Space Telescope Observes 3I/ATLAS1"

carlsborg — Wed, 27 Aug 2025 06:55:50 +0000

They released a paper. Preprint linked in page.

NASA's Webb Space Telescope Observes 3I/ATLAS1

carlsborg — Wed, 27 Aug 2025 06:55:50 +0000

Article URL: https://science.nasa.gov/blogs/3iatlas/2025/08/25/nasas-webb-space-telescope-observes-interstellar-comet/

Comments URL: https://news.ycombinator.com/item?id=45036272

Points: 2

# Comments: 1

New comment by carlsborg in "One universal antiviral to rule them all?"

carlsborg — Tue, 26 Aug 2025 18:11:00 +0000

Both are broad spectrum antivirals, but completely different mechanism.

DRACO "is a chimeric protein with one domain that binds to viral double stranded RNA (dsRNA) and a second domain that induces apoptosis when two or more DRACOs crosslink on the same dsRNA." (Ridder et al 2011). This article is about packaging mRNA for a set of 10 interferon-stimulated genes that express multiple proteins that target various stages of viral replication.