Hacker News: cassepipe

New comment by cassepipe in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"

cassepipe — Mon, 15 Jun 2026 21:20:13 +0000

Fair enough but it's not by Scott Alexander but a guest post by David Schneider-Jospeh

EDIT: They edited their message to reflect that

New comment by cassepipe in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"

cassepipe — Mon, 15 Jun 2026 17:17:27 +0000

I believe you don't have read the link I posted because its author does address the narrative you present here

But again I am not saying you are wrong and I am even sympathetic to this narrative but ultimately, unconvinced, either way

New comment by cassepipe in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"

cassepipe — Mon, 15 Jun 2026 16:57:11 +0000

This is just one person's (informed I assume) opinion tough. It does sound like common sense but alas common sense is rarely a good guide when it comes down to how the body works.

I don't have a dog in this fight and I don't remember that much but I read someone's "in defense of the amyloid hypothesis" with interest. So if you want an counterpoint, you can go read https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...

New comment by cassepipe in "OCaml Onboarding: Introduction to the Dune build system"

cassepipe — Mon, 08 Jun 2026 20:33:06 +0000

When I started learning make it wouldn't work and I wouldn't understand why so I dug into it and now I understand how it works and I can make it work but seasonned programmers still tell me my makefiles are wrong and then proceed to use even more arcade parts that render their makefiles incomprehensible. At some point I just gave up makefiles for anything non-trivial and went over to xmake where life is mostly simple and I never do it wrong.

New comment by cassepipe in "Dopamine Fracking"

cassepipe — Mon, 08 Jun 2026 09:54:10 +0000

As someone who has struggled with understanding Adorno for a long time, I found this recent review of a book about Frankfurt School a pleasant read : https://www.astralcodexten.com/p/book-review-the-dialectical...

New comment by cassepipe in "New drug 'functionally cures' many hepatitis B virus infections"

cassepipe — Mon, 08 Jun 2026 09:48:30 +0000

Aren't you confusing with HSV ?

New comment by cassepipe in "ESP32-S31"

cassepipe — Wed, 03 Jun 2026 17:21:27 +0000

Thanks.I can't believe they chose non-arcane, memory-friendly letters. Kind of rare in naming hardware I feel (unless it's not ?)

New comment by cassepipe in "Are You Enjoying Our Linguine? (2025)"

cassepipe — Wed, 03 Jun 2026 17:18:17 +0000

I feel like in countries which are mostly ethnostates, there is a tension around remnants of tradition and the business world trying to open up the culture to gain some new market opportunities (Unsure how to state this more neutrally). I think this tension is interesting and I think that in the U.S it feels like the market systematically has the upper hand.

I am not sure this holds scrutiny so I'd love to read a counter

New comment by cassepipe in "Are You Enjoying Our Linguine? (2025)"

cassepipe — Wed, 03 Jun 2026 17:00:32 +0000

Your list is imcomplete I believe:

Too merciful to slaveowners before, too merciful to warmongers as of late and way too merciful to grifters for as long as this country has existed.

I learnt that you should never bet against the U.S but I don't know how much longer you will be able to waste that seemingly infinite potential.

Good times creates bored, ignorant men. Bored ignorant, men create bad times.

New comment by cassepipe in "ESP32-S31"

cassepipe — Wed, 03 Jun 2026 16:53:10 +0000

Curious: What does the "imac" stand for in the architecture target name ?

New comment by cassepipe in "Open Repair Data Standard"

cassepipe — Tue, 02 Jun 2026 20:20:55 +0000

Wasn't sure what was best to post the actual spec lives there: https://standard.openrepair.org/standard.html

Open Repair Data Standard

cassepipe — Tue, 02 Jun 2026 19:37:10 +0000

Article URL: https://openrepair.org/open-data/open-standard/

Comments URL: https://news.ycombinator.com/item?id=48375150

Points: 162

# Comments: 13

New comment by cassepipe in "Debug Project"

cassepipe — Tue, 02 Jun 2026 11:52:28 +0000

The main concern was that animal who feed on mosquitoes (birds) might be affected but most mosquitoes don't bite and the animals who eat them also eat a lot of other insects. I would worry much more about pesticides that may be the reason for the great insect population collapse.

New comment by cassepipe in "KDE at 30"

cassepipe — Mon, 01 Jun 2026 19:25:21 +0000

I tried KDE 5 years ago and frankly I was a bit lost. Too many options and too many papercuts. Still better that the dumbed down GNOME experience but I went for Cinnamon instead.

I tried it again today and it really felt quite polished, no papercuts, no feeling of being overwhelmed, no bugs, good newcomer experience... I think this is it. They made it.

New comment by cassepipe in "What Gets Kept"

cassepipe — Thu, 28 May 2026 23:32:57 +0000

Meh. You could also say that he went to the italian restaurant and the pasta was undercooked.

I understand the argument but what is the "dish" OTR is serving ?

So instead of using a metaphor, can you tell us what you experienced when reading the kind of lines he is referring to when you read the book ?

New comment by cassepipe in "Social Animus"

cassepipe — Thu, 28 May 2026 23:24:13 +0000

I don't think people have to be humble if they are proud of what they have produced and get recognition to validate them. I am much more concerned by her holding views that are in favor of hurting others.

New comment by cassepipe in "What Gets Kept"

cassepipe — Wed, 27 May 2026 15:25:35 +0000

Also it's terribly boring

New comment by cassepipe in "What Gets Kept"

cassepipe — Wed, 27 May 2026 15:15:51 +0000

Where you see outrage, I see frustration from forcing oneself to read something everyone told you was a must-read

> carefully distilled philosophical and moral clarity

I wasn't looking for moral clarity, I was looking for something interesting to read about the world they live in, some insight

From the review posted above:

"But this is supposed to be okay, because they are visionaries. Their vision is to use the words “holy”, “ecstatic”, and “angelic” at least three times to describe every object between Toledo and Bakersfield. They don’t pass a barn, they pass a holy vision of a barn, a barn such as there must have been when the world was young, a barn whose angelic red and beatific white send them into mad ecstasies. They don’t almost hit a cow, they almost hit a holy primordial cow, the cow of all the earth, the cow whose dreamlike ecstatic mooing brings them to the brink of a rebirth such as no one has ever known."

New comment by cassepipe in "What Gets Kept"

cassepipe — Wed, 27 May 2026 12:01:49 +0000

TIL I learned that not liking a-holes and to find the story their repititive adventures boring is pearl-clutching

New comment by cassepipe in "What Gets Kept"

cassepipe — Wed, 27 May 2026 08:57:47 +0000

I have had my on the road phase when I was around 18 when I read the book but I did not vibe at all with it. I found all the characters highly unlikeable and couldn't help to think that I much better friends, even my wildest ones. But I wasn't wild enough I guess because I actually managed to finish the book, like a well behaved schoolboy.