Hacker News: chromatin

New comment by chromatin in "Stripe in talks to buy OpenRouter for ~10B"

chromatin — Thu, 23 Jul 2026 22:21:48 +0000

Extremely relevant:

Ramp Router: https://news.ycombinator.com/item?id=48987253

New comment by chromatin in "Ramp Router"

chromatin — Tue, 21 Jul 2026 03:36:23 +0000

Looks like it will be a paid offering? Seems strange coming from a Fintech, unless they're looking to pivot.

New comment by chromatin in "Mesh LLM: distributed AI computing on iroh"

chromatin — Sun, 12 Jul 2026 13:47:20 +0000

A 1 gbe local network should have < 1 msec latency per hop so theoretical upper bound is substantially higher than 30 tps (again assuming instantaneous compute) => thus network latency should not be the limiting factor in reality, no?

New comment by chromatin in "An update on residential proxies and the scraper situation"

chromatin — Sun, 12 Jul 2026 00:19:03 +0000

I would very much like to see a Lightning-Network based 402 standard succeed!

New comment by chromatin in "How many of the 170k English words do you know?"

chromatin — Fri, 19 Jun 2026 15:52:52 +0000

The UX is awful - I bailed out at 25/100 JUST IN LEVEL ONE (BASICS)

Might I suggest adaptive difficulty? After getting 10, 15, 20 correct in a row it should scale up the difficulty immediately, rather than waiting for 100 in the basic level 1...

New comment by chromatin in "How much of Thermo Fisher's antibody data has been manipulated?"

chromatin — Mon, 08 Jun 2026 12:10:18 +0000

We noticed this years ago when looking at -- IIRC -- ikaros antibodies. They were clearly faked. Lacking any sort of platform to gain attention we moved on to Abcam and our lab just sort of maintained a mental map of who not to purchase ANYTHING immuno- from.

New comment by chromatin in "Biohub releases a world model of protein biology"

chromatin — Sun, 07 Jun 2026 19:45:27 +0000

> Do you need to predict when AP-MS is so cheap?

Yes because a core reason fro this technology is evaluation of de-novo designs (small peptide binders; scFvs; sdAbs)

New comment by chromatin in "The perils of UUID primary keys in SQLite"

chromatin — Sat, 06 Jun 2026 17:20:24 +0000

If you had read the article, you'd have seen that UUIDv4 with Rowid was slightly slower than UUIDv7

New comment by chromatin in "Software Developers Say AI Is Rotting Their Brains"

chromatin — Wed, 13 May 2026 14:50:06 +0000

Is this substantially different, cognitively or skills-wise, than moving into management and directing a team to write code, but no longer writing code oneself?

New comment by chromatin in "Claude Platform on AWS"

chromatin — Tue, 12 May 2026 15:02:35 +0000

"Practice is policy"

New comment by chromatin in "US inflation jumps to 3.8% as energy costs surge from Iran war"

chromatin — Tue, 12 May 2026 14:54:05 +0000

I disagree and think GP poster is right on the money.

There are many ways in which inflation numbers are cooked; just one of them is the hedonic adjustment [1].

Others include an un-representative basket of goods.

The basket of goods is adjusted every 2 years, but not necessarily in a way that mirrors the way real households adapt their spending patterns to increased prices.

Owner equivalent rent (LOL) massively lags behind home prices.

Honestly, when 10s or hundreds of millions of people's perception does not match *Official Government Numbers*, then it's reason to suspect that the official numbers are a poor metric.

[1] https://www.bls.gov/cpi/quality-adjustment/

New comment by chromatin in "Google releases Gemma 4 open models"

chromatin — Sat, 04 Apr 2026 11:13:53 +0000

I love that you are doing this test. However, as it purports to be a test of "English-to-SQL", your hardest question (Q9) seems ungrammatical:

> Show order lines, revenue, units sold, revenue per unit (total revenue ÷ total units sold), average list price per product in the subcategory, gross profit, and margin percentage for each product subcategory.

In particular, the clause "in the subcategory, gross profit, and margin percentage for each product subcategory" is ambiguous, and I wonder if more models would pass if the English were reformulated to be correct.

(it's also notable that Claude Opus 4.6 and Sonnet 4.6 both "missed" this one)

New comment by chromatin in "Show HN: An open-source safety net for home hemodialysis"

chromatin — Fri, 20 Mar 2026 19:44:25 +0000

Incredible; I'll let my patients* on Home HD know about this.

*not a nephrologist but have several pts on home hd

New comment by chromatin in "Delve – Fake Compliance as a Service"

chromatin — Fri, 20 Mar 2026 19:37:20 +0000

> Delve was founded in 2023 by Karun Kaushik and Selin Kocalar, both Forbes 30 Under 30 members and MIT dropouts who met as freshmen.

Forbes 30 under 30 remains undefeated

New comment by chromatin in "GPT‑5.3 Instant"

chromatin — Wed, 04 Mar 2026 22:36:40 +0000

No, not at all. My unqualified internet diagnosis is that you may have high anxiety.

New comment by chromatin in "Sheldon Brown's Bicycle Technical Info"

chromatin — Fri, 06 Feb 2026 18:24:05 +0000

When I was a young(er) postdoc and had to overhaul my bicycle -- my main transportation to work-- this site was invaluable. Forever grateful to Sheldon.

New comment by chromatin in "The 600-year-old origins of the word 'hello'"

chromatin — Sat, 17 Jan 2026 16:46:58 +0000

> According to linguists, elongated variations such as "heyyy" could be construed as flirtatious, "hellaw" might suggest you're from the southern US,

I am from the Southern US and I am definitely not familiar with this phonetic form. Could be what a BBC writer _imagines_ a Southerner sounds like

New comment by chromatin in "Nabokov's guide to foreigners learning Russian"

chromatin — Wed, 24 Dec 2025 15:46:27 +0000

I found Croatian significantly easier than Czech, perhaps because of centuries (millenia?) of trans-Adriatic Italian influence?

New comment by chromatin in "Unifi Travel Router"

chromatin — Wed, 24 Dec 2025 15:03:49 +0000

Time is your most precious commodity.

New comment by chromatin in "Self-hosting a Matrix server for 5 years"

chromatin — Mon, 01 Dec 2025 21:51:18 +0000

Conduit [1] has retention policies [2] for media and attachments!

[1] https://conduit.rs/ and https://gitlab.com/famedly/conduit [2] https://gitlab.com/famedly/conduit/-/blob/next/docs/configur...