China's factories are in another world - Mar 23, 2025

Chinese factories build fire trucks for under $400,000 in six weeks. In the US, it's $2 million in 4 years - Apr 19, 2025

Iran is blowing up $500 million radars. China's export bans mean they are gone forever. - Mar 16, 2026

Long ago I took a CPU architecture class and we implemented designs in Verilog as a final project. Apparently people who took the class in the late 90s (before my time) could actually tape-out their designs and pay a few hundred dollars to get fabbed chips as part of a multiproject wafer. I was always curious if those chips actually worked, or just looked pretty.

All I’m trying to say is that butter isn’t the enemy. Maybe commercial dairy production practices are the enemy, won’t argue with that.

[1] https://big-stupid-jellyfish.github.io/GFMath/pages/llm-quan...

Opus 4.5 seems good too, though getting dumber. OpenAIs fine tuning is clearly built to toe the professional medical advice line, which can be good and bad.

The main problem with ALA is that to have the good effects attributed to omega-3s, it must be converted by a limited supply of enzymes into EPA and DHA. As a result, only a small fraction of it has omega-3's effects — 10%–15%, maybe less. The remaining 85%–90% gets burned up as energy or metabolized in other ways. So in terms of omega-3 "power," a tablespoon of flaxseed oil is worth about 700 milligrams (mg) of EPA and DHA. That's still more than the 300 mg of EPA and DHA in many 1-gram fish oil capsules, but far less than what the 7 grams listed on the label might imply.

https://www.health.harvard.edu/heart-health/why-not-flaxseed...

Also, beware of omega 6 fats. Seed oils (corn, soy, canola) used in commercial food products are incredibly omega 6 dominant in terms of polyunsaturated fat content. Consequently, the ratio of omega 3 to omega 6 fats we consume has plummeted as food production has industrialized. Omega 3 fats are precursors to generally anti-inflammatory signaling compounds, whereas omega 6 fats are precursors to pro-inflammatory signaling compounds. The bias in fat intake leads to more pro-inflammatory signaling in the body, and a lot of alt health types have alleged this is a major causative factor in the obesity epidemic.

This is important for depression, because chronic brain inflammation as a cause of depression was one of the going hypotheses at least a decade ago when I last looked into all of this. Upping omega 3 intake is an intervention that can address chronic inflammation, which is potentially why it improves some cases of depression.

Pretty much nobody in the west needs more omega 6s these days. I hear even farmed salmon eat primarily corn and soy based feeds these days, meaning their fat ratio is skewed much more heavily toward omega 6 than wild salmon and fish.

[1] https://www.youtube.com/watch?v=x7cQ3mrcKaY

There's lots of carrots (compensation, high quality desk jobs) and sticks (promotion structures, threat of offshoring). The really annoying and egregious aspects of corporate speak are easy targets for ire and take the heat, while the subtle euphemisms make the actual questionable projects easier to live with day to day.

- Producing organisms with capable, healthy mitochondria requires mitonuclear compatibility (mitochondrial genome is from mother, nuclear genome is from both parents, energetic capacity and regulation requires both genomes to coordinate) and evidence is that organisms select highly for offspring that have higher mitonuclear compatibility and more capable mitochondria. Offspring that don't have capable enough mitochondria don't make it to term. For example, mammals are more permissive about mitonuclear compatibility than birds (who have extremely high energetic requirements) so mammals are more fecund, but we're also more likely to get cancer from inefficient mitochondria throwing off reactive oxygen species.

- Chris Palmer, a Harvard medical school MD psychiatrist, put out a book a few years ago hypothesizing most mental disorders as brain metabolic disorders — brain mitochondria problems. I've seen mixed reviews on the hypothesis (which I like) but it sure is interesting.

Taken together these imply: 1) some people get more energy than others at a biological level, 2) that impacts mental health, 3) there are interventions that can improve the energy baseline we each were given (as discussed in Palmer's book/talks).

https://docs.astral.sh/uv/guides/scripts/#using-different-py...

@dang or another mod, can you add that to the title? Thanks!