Hacker News: derekja

New comment by derekja in "FDA clears blood test to aid evaluation for Alzheimer's disease"

derekja — Mon, 24 Aug 2026 21:52:36 +0000

May not completely stop it, but lecanemab and donanemab are certainly considered to be disease-progression modifying at this point.

New comment by derekja in "Sleep regularity is a stronger predictor of mortality risk than sleep duration (2023)"

derekja — Wed, 15 Jul 2026 16:09:28 +0000

OTC in canada

New comment by derekja in "What Ozempic does to the gut-brain axis"

derekja — Sun, 28 Jun 2026 03:53:23 +0000

The primary concern is reduced stomach acid leading to nutrient deficiencies, particularly b12. There have been some long term studies correlating to dementia as a result. And some studies that have not found this. So the jury is still out, but keeping an eye on some nutritional markers is not a bad idea.

New comment by derekja in "Ask HN: Why is the HN crowd so anti-AI?"

derekja — Sat, 06 Jun 2026 19:02:05 +0000

On the medical pieces, a very nice agentic medical AI worth looking at is https://biomni.phylo.bio

New comment by derekja in "Comma openpilot – Open source driver-assistance"

derekja — Sat, 24 Jan 2026 03:44:45 +0000

Yup, because you get to be personally responsible for any outcomes just like you would be if you were driving without ai assistance. If you aren’t comfortable building and testing an open source project then it isn’t for you.

New comment by derekja in "OBS Studio 32.1.0 Beta 1 available"

derekja — Thu, 15 Jan 2026 18:43:14 +0000

Complicated interaction with macOS Sequoia though. I’m on apple silicon and trying to capture on a multimon setup (although only capturing one screen) and the capture freezes painfully often. Going to window capture helps but doesn’t eliminate the problem. Seems to be related to ScreenCaptureKit. I’ve tried a lot to debug it but so far failed.

New comment by derekja in "Handy – Free open-source speech-to-text app written in Rust"

derekja — Sun, 28 Sep 2025 05:35:34 +0000

I’ve been enjoying Kokoro

Amazing what it can do with only 82M parameters

https://www.kokorotts.io/

New comment by derekja in "Here Come the Anti-Woke AIs"

derekja — Mon, 22 Apr 2024 22:43:33 +0000

https://archive.is/eVlvh (sorry, that didn't work at all!!)

New comment by derekja in "Ant Geopolitics"

derekja — Tue, 27 Feb 2024 17:24:15 +0000

I've been really enjoying the AntsCanada youtube channel lately. He stages ant wars in a controlled environment and films them really well. https://www.youtube.com/channel/UCONd1SNf3_QqjzjCVsURNuA

New comment by derekja in "Ask HN: What companies have blown you away with their customer support?"

derekja — Tue, 31 Oct 2023 02:15:34 +0000

Been quite a few years ago, but Dell support came to a tiny campground 100 miles from anywhere and swapped out my laptop motherboard within 24 hours of it failing. Sadly, their support is no longer as extraordinary.

New comment by derekja in "The mortgage market is so bad lenders want ex-employees to give back bonuses"

derekja — Mon, 30 Oct 2023 02:22:55 +0000

Thanks. I get it on ios as well. Hadn’t thought to try a vpn.

New comment by derekja in "Marc Andreessen's Horrifying, Silly Vision of who should rule the world"

derekja — Sun, 29 Oct 2023 13:15:26 +0000

https://web.archive.org/web/20231028123512/https://www.nytim...

New comment by derekja in "Watch this guy work and you'll finally understand the TikTok era"

derekja — Sat, 28 Oct 2023 17:49:52 +0000

https://web.archive.org/web/20231021002437/https://www.wired...

New comment by derekja in "Huawei teardown shows chip breakthrough"

derekja — Mon, 04 Sep 2023 10:42:52 +0000

I had always read that (perhaps over-hopefully) as referring to the structural incentives of the Chinese economic system not leading to innovation rather than a racist statement that Asians can't innovate. Neither statement seems completely accurate but the former is considerably less offensive.

New comment by derekja in "Ask HN: How to monetize a website that is making views?"

derekja — Tue, 22 Aug 2023 01:25:22 +0000

Perhaps some more model work too! I'm about a 5 and it called me 1.8

Nice idea and implementation, though!

New comment by derekja in "Scientists hit with massive bills after speaking at COVID-19 ‘webinars’"

derekja — Sun, 23 Jul 2023 14:14:13 +0000

Colloquially I think you may be right, but the dictionary definition makes it appropriate here: Demise Definition & Meaning noun ; a · death ; b · a cessation of existence or activity ; c · a loss of position or status.

New comment by derekja in "Ask HN: How could I safely contact drug cartels?"

derekja — Sat, 15 Jul 2023 15:44:52 +0000

"lot of deaths over the last few years from fentanyl in pot."

Can you share a case where this has been confirmed? There was some hysteria in Connecticut last year, but my understanding is that this has never actually happened. I'd love to see a pointer to a coroner's report on a case of accidental fentanyl ingestion from laced pot having led to an overdose.

I have seen cases of fentanyl test strips coming up positive, but only with incidental contamination rather than anything in concentrations that are actually hazardous. Fentanyl decomposes at under 300 degrees and pot burns at 450, so it is not actually a viable route to ingestion.

New comment by derekja in "Tell HN: LinkedIn banned me because of my avatar, in the middle of my fundraise"

derekja — Thu, 13 Jul 2023 03:16:01 +0000

Nice! I read that comic every day :-)

New comment by derekja in "A quick look back at when Microsoft made an interactive Barney toy"

derekja — Sun, 09 Jul 2023 20:29:48 +0000

Nice. I was at msft then and had access to the code. My friend and I had a great time hacking his daughter's Barney to make it say things it shouldn't.

New comment by derekja in "Prigozhin Is Said to Be in Russia, as Wagner Mystery Deepens"

derekja — Sat, 08 Jul 2023 14:01:40 +0000

https://web.archive.org/web/20230707003746/https://www.nytim...