That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.

I’m comfortable with org mode operations and formatting although I don’t know how to use drawers or properties or what’s the point of archiving. I like using org-ref, and I see a version of that has been added officially this version.

I never learned a more clever way of using org mode. Any tips or guides?

I enjoy that too. It's also essential if you don't have a car. I think it's a shame that Amtrak no longer has timetables for download. Maybe it's to hide the sad fact that there are only 10-15 trains per day in one direction on the northeast corridor.

It makes sense for the military to recognize the other forces that pose the biggest threat. But regarding declarations by politicians, it appears to me that internal politics in both countries are driving politicians to make such statements. As in, both American and Chinese leadership see advantage in creating an external enemy. Naturally, as China's power rises, the relationship changes texture, but how much of our attitude change is recognition of the changed situation versus a change in attitude induced by the political class?

>This one could apply to our relationship with China maybe?

>> Yes, we quarrel with the French. The members of a family argue pretty freely inside the home ; We quarrel with our allies, We don't quarrel with our enemies -- we fight them.

With that said, I wouldn't interpret the US relationship with China as one of alliance nor as one of enmity (yet).

There isn't evidence that Apple's team has run out of architectural improvements however, so I do think performance gains are still out there. Plus there's always the possibility of going to smaller semiconductor processes.

Consider a Tesla that gets ~250 miles of range per full cycle. The battery would reach 1000 cycles after 250k miles of driving, at which point you have a pretty old car. Depending on factors like time, environmental conditions, driving style, a battery replacement might be necessary at some point in the car's life. So the batteries in EVs probably cannot sustain thousands of cycles. The battery capacity is large enough that the overall cycle count is reasonable within the lifespan of the vehicle, and the battery cooling system keeps degradation reasonable given the high demands EV batteries must fulfill.

I need to try to get up from my desk more when stuck. There's a bit of inertia to overcome in getting up from my seat, but it would probably be more efficient, thinking wise.

That doesn't sound so exciting to me.