Hacker News: dpatrick86

New comment by dpatrick86 in "Hard-braking events as indicators of road segment crash risk"

dpatrick86 — Tue, 10 Feb 2026 00:23:02 +0000

It would be really interesting if cars did this by default. Maybe it could figure out your threshold, how much of an outlier you are, and then you could opt-in to a new threshold that's somewhat better and/or closer to average.

New comment by dpatrick86 in "Notes on OpenAI's new o1 chain-of-thought models"

dpatrick86 — Fri, 13 Sep 2024 15:51:14 +0000

Artificial is fine and playing word games for pedants is a trap.

New comment by dpatrick86 in "Paul Graham is leaving Twitter for now"

dpatrick86 — Sun, 18 Dec 2022 23:11:22 +0000

Getting big "on a bender" vibes from Elon right now...

New comment by dpatrick86 in "Base editing: Revolutionary therapy clears girl's incurable cancer"

dpatrick86 — Tue, 13 Dec 2022 05:19:07 +0000

Some use cas9, such as dead cas9 (has endonuclease activity removed), and others do not.

Great interview where Dr. George Church talks base editing and CRISPR: https://www.foundmyfitness.com/episodes/george-church

New comment by dpatrick86 in "Jerry Lee Lewis has died"

dpatrick86 — Fri, 28 Oct 2022 18:04:35 +0000

This is being reported as false https://ew.com/music/jerry-lee-lewis-alive-after-erronerous-...

New comment by dpatrick86 in "NIH will invest $1B to investigate 'long Covid'"

dpatrick86 — Fri, 05 Mar 2021 05:36:50 +0000

At least in the case of the heart, there’s the beginnings of evidence that is suggestive of the fact that the damage is not simply incidental to systemic inflammation. https://medicine.wustl.edu/news/covid-19-can-kill-heart-musc...

New comment by dpatrick86 in "Why cancer cells waste so much energy"

dpatrick86 — Fri, 15 Jan 2021 18:01:30 +0000

Your point may be broadly true but subject to important caveats. Cancer is a very heterogeneous disease. There is evidence that _some_ cancers can use, for example, acetoacetate. https://www.sciencedaily.com/releases/2017/01/170112141359.h...

New comment by dpatrick86 in "Managing an underperformer who thinks they’re doing great"

dpatrick86 — Wed, 09 Dec 2020 18:24:12 +0000

Wow, refreshing. To me, the most interesting part here is the incentive. It sounds like they ultimately just wanted to rise to the standard once it was made exhaustively clear. The important part here probably being that, by including peers, they know the feedback is coming from the right place, which is disarming.

New comment by dpatrick86 in "Immune discovery 'may treat all cancer'"

dpatrick86 — Tue, 21 Jan 2020 04:51:43 +0000

Might be inhibiting sirtuin activity... http://www.jbc.org/content/277/47/45099.short

New comment by dpatrick86 in "Progress of anti-aging therapies by clinical trial stage"

dpatrick86 — Fri, 17 Jan 2020 01:06:05 +0000

What makes you think NMN has been "proven to be safe?" That's a pretty strong standard to conform to. There's virtually no clinical work that's been done at all, for starters.

A lot of genuine promising research in animals, but you also have this animal cancer model that suggests at least a little caution... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448588/

New comment by dpatrick86 in "“Why We Sleep” Is Riddled with Scientific and Factual Errors"

dpatrick86 — Sat, 16 Nov 2019 05:58:29 +0000

Taken in light of the existence of the glymphatic system, a robust mechanism of clearance activated by slow wave sleep, what is more likely... misfolded protein accumulation is incidental to the loss of sleep during the course of fatal familial insomnia or loss of sleep is incidental to what is actually a disease of misfolded proteins?

New comment by dpatrick86 in "Gene name errors are widespread in the scientific literature (2016)"

dpatrick86 — Mon, 23 Sep 2019 22:04:12 +0000

Allele misassignment is another rampant issue. https://www.ncbi.nlm.nih.gov/pubmed/18154681?dopt=Abstract

New comment by dpatrick86 in "Anaxagoras Was Exiled for Claiming the Moon Was a Rock"

dpatrick86 — Mon, 22 Jul 2019 16:48:17 +0000

I appreciate your comment, despite not relating to it very well and it seeming a bit strange to me.

I know that might come across a bit odd, but it's refreshing to actually try to understand other viewpoints and to do so inoffensively.

New comment by dpatrick86 in "Pig brains partially revived four hours after death"

dpatrick86 — Wed, 17 Apr 2019 17:45:12 +0000

It sure seems like patterns of cortical activation (or something like that) could be compared to some sort of waking standard to take a very good measured guess at some point.

New comment by dpatrick86 in "A study of ethicists finds they’re no more ethical than the rest of us"

dpatrick86 — Sat, 30 Mar 2019 18:02:14 +0000

That's awfully late in life to be developing a foundation for morality. It seems far more likely to be extremely influenced by early upbringing.

More controversially, there may even be a genetic component too. https://www.sciencedaily.com/releases/2019/02/190225145632.h...

We are still so early in the understanding of ourselves and, by extension, society.

New comment by dpatrick86 in "History of Biosphere 2"

dpatrick86 — Fri, 29 Mar 2019 15:42:51 +0000

Interestingly, the legacy of Biosphere 2 includes the recently emerging fasting and fasting-mimicking science demonstrating some interesting healthspan promoting properties. Dr. Roy Walford of Biosphere 2 helped kick off the caloric restriction field thanks to his experiences.

Valter Longo explains that his tenure in Walford's lab as one of the preludes to some of his great work demonstrating that some of the benefits of CR are achievable by using discrete periods of fasting as opposed to long-term restriction, which has obvious challenges of practicality and undesirable effects like emaciation just to name a few.

He talks about Dr. Walford's time in biosphere 2 and how it impacted both Walford's work and, ultimately, his own.

Starts around here around 00:01:45... https://www.youtube.com/watch?v=d6PyyatqJSE&t=00h01m43s

New comment by dpatrick86 in "Fish oil supplements linked to prostate cancer (2013)"

dpatrick86 — Sat, 23 Mar 2019 19:13:22 +0000

This was based on the SELECT trial data, which means that it could just as easily be measuring the effects of a very large and prolonged dose of 400 IU of alpha-tocopherol as it is omega-3. Greater than 12x RDA.

Moreover, it's been many years since this was published. If prostate cancer-promoting effects were so plainly an obvious effect of marine omega-3 supplementation, you'd expect to have seen it abundantly replicated by now.

New comment by dpatrick86 in "Alzheimer’s Drug Failure Leaves Scientists Seeking New Direction"

dpatrick86 — Sat, 23 Mar 2019 17:15:59 +0000

What if it's both?

New comment by dpatrick86 in "Microbiome interactions shape host fitness"

dpatrick86 — Wed, 13 Feb 2019 15:40:39 +0000

VSL#3 is one that has a lot of clinical research (search Google Scholar or PubMed). The catch is that the company producing VSL#3 no longer uses the formula that historically was used in the vast array of clinical research conducted. Whether some of the changes matter is up for debate. However, the original formulation is now sold under brand name Visbiome.

https://www.visbiome.com/blogs/news/maryland-federal-jury-un...

New comment by dpatrick86 in "Gut bacteria may offer a treatment for autism"

dpatrick86 — Sat, 08 Dec 2018 19:06:41 +0000

Some research is adopting this pattern too. A great example is Dr. Satchin Panda's clinical trial on time-restricted eating. You self-select an eating window and then document it through the app. Pretty cool stuff. mycircadianclock.org