Hacker News: eig

New comment by eig in "Claude designed protein binders against scorpion neurotoxins"

eig — Tue, 20 Oct 2026 20:08:43 +0000

While Clinical Trials are the most expensive step and have a 90% failure rate, it is not the *source* of the failures, it's just where failures are revealed.

Much of whether or not a candidate drug will succeed was determined all the way back in the design/discovery stage. If we can design better drugs, then we would enjoy a higher probability of success in the later clinical trials.

The single biggest improvement to pharma drug development would be from increasing the probability of success in clinical trials.

New comment by eig in "[dead]"

eig — Fri, 18 Sep 2026 12:38:08 +0000

“ This is not the smoothness problem solution, but rather the Burgers vortex, an exact solution of the Navier–Stokes equations published by J. M. Burgers in 1948, chosen because it has the same anatomy: fluid drawn inward in a plane, stretched along the axis and thrown out of both ends, spinning fastest in a core.”

What Makes Art Great?

eig — Thu, 20 Aug 2026 15:50:46 +0000

Article URL: https://nabeelqu.co/what-makes-art-great

Comments URL: https://news.ycombinator.com/item?id=49376328

Points: 2

# Comments: 0

TSMC Uses Old Fabs to Make New Chips [video]

eig — Mon, 17 Aug 2026 00:07:42 +0000

Article URL: https://www.youtube.com/watch?v=cDxVYQrxeiQ

Comments URL: https://news.ycombinator.com/item?id=49325115

Points: 25

# Comments: 8

New comment by eig in "Drake Anthony Recreates the Mechanical Bulb First Seen in 1675"

eig — Thu, 16 Jul 2026 12:39:11 +0000

This blog post is essentially a summary of the original video.

https://www.youtube.com/watch?v=0Y-9GbsS9Fg

New comment by eig in "GPT-5.6"

eig — Thu, 09 Jul 2026 17:14:05 +0000

Funny to see that they did not include Fable 5 in their GeneBench and LifeSciBench comparisons because "it does not answer advanced biology questions and refuses the majority of questions in this eval".

Winner by default!

New comment by eig in "Text AI watermarks will always be trivial to remove"

eig — Thu, 02 Jul 2026 17:45:12 +0000

I presume all the Foundation AI companies have been doing this for years, to avoid training models on their own generated data?

New comment by eig in "Microbubbles in Medicine"

eig — Fri, 26 Jun 2026 13:00:09 +0000

The microbubbles in scuba diving that cause the bends are the ones trapped in joint space fluid. That fluid doesn't circulate at a useful rate, so unfortunately you can't really "burst them somewhere else" =(

New comment by eig in "Show HN: Chess-Inspired Roguelike"

eig — Fri, 26 Jun 2026 00:19:25 +0000

This is a great puzzle game. I think it actually teaches the concept of "piece coordination" in chess very well.

One suggestion is to have all enemy pieces move simultaneously. I expected that the losing condition is that I am threatened and there are no unthreatened squares to move (checkmate).

However, since the opponents move one-at-a-time, I found that even if I moved to a safe square, sometimes I could be both threatened and captured in the same move! Which is somewhat different from normal chess, since now you have to consider the possible orders in which the opponents move. So even moving to unthreatened squares could be a game over.

New comment by eig in "Show HN: Gerrymandle - Daily puzzle game where you redraw electoral districts"

eig — Thu, 18 Jun 2026 21:01:58 +0000

In real-life, before the election there is a margin of error on the support of a bloc.

If you interpret a "tie" in this game as "either party could win within the margin of error", then it becomes a lot closer to solving the problem that gerrymandering algorithms try to solve in real life!

New comment by eig in "Correlated randomness in Slay the Spire 2"

eig — Tue, 16 Jun 2026 12:28:32 +0000

The game stores and allows you to see the RNG seed that controls the run's events and layout. The developers want players to be able to share seeds that produce interesting runs.

That requirement is what made this problem difficult for the devs to solve.

New comment by eig in "How much of Thermo Fisher's antibody data has been manipulated?"

eig — Mon, 08 Jun 2026 12:02:36 +0000

The only reason I think biotech companies are not yet raising hell (and invoking the False Claims Act) is that Thermo Fisher's antibodies are already known to be notoriously bad, and everyone serious seems to have to validate everything themselves.

New comment by eig in "How much of Thermo Fisher's antibody data has been manipulated?"

eig — Mon, 08 Jun 2026 11:57:20 +0000

I'd treat this about the same as datasheets for mechanical or electrical parts.

When I buy an electronic component as a regular consumer I expect the datasheet "typical" values to be accurate 90% of the time. I can imagine larger industrial customers would really raise a stink if it's worse than that. However, any critical components in my circuit must be verified and "binned", and that's on me.

New comment by eig in "Have You Seen the New Excel?"

eig — Thu, 30 Apr 2026 03:39:06 +0000

In case people don't realize, this is satire.

New comment by eig in "Vcad: Free BRep CAD in the Browser"

eig — Fri, 30 Jan 2026 21:37:02 +0000

Man, I really tried but I can't even get through the article because it sounds so AI written. I feel like I'm scrolling on LinkedIn...

Using AI, Mathematicians Find Hidden Glitches in Fluid Equations

eig — Fri, 09 Jan 2026 16:54:03 +0000

Article URL: https://www.quantamagazine.org/using-ai-mathematicians-find-hidden-glitches-in-fluid-equations-20260109/

Comments URL: https://news.ycombinator.com/item?id=46555877

Points: 5

# Comments: 0

Elon Musk diving into 2026 midterms for the GOP

eig — Tue, 16 Dec 2025 14:45:07 +0000

Article URL: https://www.axios.com/2025/12/16/elon-musk-donations-midterms-republicans-trump

Comments URL: https://news.ycombinator.com/item?id=46289136

Points: 6

# Comments: 2

New comment by eig in "Feynman vs. Computer"

eig — Thu, 04 Dec 2025 17:04:38 +0000

What is the advantage of this Monte Carlo approach over a typical numerical integration method (like Runge-Kutta)?

New comment by eig in "1D Conway's Life glider found, 3.7B cells long"

eig — Wed, 03 Dec 2025 17:36:19 +0000

Is there a visualization of the glider in the thread? Would love to see how it evolves with one dimension being time.

New comment by eig in "High speed X-ray video: jumping beans, wind-up toys and more"

eig — Tue, 11 Nov 2025 15:29:07 +0000

Be rest assured Ben’s previous job was in the medial imaging industry. While he worked on MRI machines rather than ionizing radiation, I think he’s very well aware of the dangers of X rays and has many projects dealing with ionizing radiation. There’s a lot of bad safety science YouTubers, Ben isn’t one of them :)

Funny thing: it’s actually rare to get radiation damage to human hands and feet since there’s not too much growing tissue there!