https://immunityageing.biomedcentral.com/articles/10.1186/s1...

Research into chemical agents that induce or inhibit this would also be of interest.

It makes sense that some neurodegenerative diseases with unknown etiologies are caused by prions or prion-like proteins.

It could be fruitful to study the rate of Alzheimer's among nursing assistants who work in elder care. I found a few resourcas stating a higher rate for caregiver's in general along with nurses.

I have thought decreased immune function from aging leads to the increased permeability of the blood brain barrier: which leads to the infiltration of pathogens and now possibly prions.

I would assume this could be, or possibly has been, studied in animal models.

For both the tire question and with respect to a youtube dowloader, the first results were on the nose with the addition of site:edu on Google.

Why this is needed and whether a noncommercial, information rich web portal should exist are questions for another thread.