Hacker News: et2o

New comment by et2o in "Cardiac implantable electronic devices' longevity: A novel modelling tool"

et2o — Thu, 27 Nov 2025 03:31:37 +0000

Cardiology fellow here. The more you have to pace the shorter the battery lasts? Struggling to see what the novelty is here.

New comment by et2o in "Mapping the off-target effects of every FDA-approved drug in existence"

et2o — Tue, 28 Oct 2025 22:23:01 +0000

People have been doing this for literally decades. Check out work by Tattonetti

New comment by et2o in "Weight-loss drug found to shrink muscle in mice, human cells"

et2o — Thu, 21 Nov 2024 01:30:32 +0000

This is most likely a good thing. It isn't killing cardiac myocytes, it's probably assisting with reverse remodeling. Fits with why we know it helps in heart failure.

New comment by et2o in "CrowdStrike Update: Windows Bluescreen and Boot Loops"

et2o — Fri, 19 Jul 2024 20:13:27 +0000

You have no idea how a hospital or modern medicine works. It needs to be online.

New comment by et2o in "CrowdStrike Update: Windows Bluescreen and Boot Loops"

et2o — Fri, 19 Jul 2024 20:09:19 +0000

Because essentially every large hospital in the USA does?

New comment by et2o in "EpiPen For Heart Attacks? Idorsia Launches Phase III Study Of Selatogrel (2021)"

et2o — Thu, 28 Mar 2024 15:57:20 +0000

None of these works nearly as well as angioplasty

New comment by et2o in "Boom announces successful flight of XB-1 demonstrator aircraft"

et2o — Fri, 22 Mar 2024 21:22:29 +0000

Just wrong. Read about the 7J7. The 787 cost something north of 20 billion to develop. The clean sheet 737 would have cost much more in today’s dollars. Boeing makes an average of less than 5% profit margin from the 1970s to now. It was a relatively obvious financial decision from Boeing’s perspective.

New comment by et2o in "Boom announces successful flight of XB-1 demonstrator aircraft"

et2o — Fri, 22 Mar 2024 20:35:45 +0000

Shame on you.

We will not have supersonic transport for average people unless outsiders do it first. There are only two meaningfully large manufacturers now, Airbus and Boeing.

Boeing and Airbus both cannot financially afford a technologically promising but possible failure now. Boeing built the 737 MAXX because they couldn’t afford a clean sheet update of 70-year old technology despite the savings. Airbus lost almost as much as the entire company was worth on the A380, kept afloat by EU subsidies.

All new technology happens for the wealthy first - we would not have smartphones today if Apple was forced to price them at the median price of cell phones in 2004.

New comment by et2o in "Sodium ascorbate treatment for sepsis moves to next phase of human trials"

et2o — Sat, 14 Oct 2023 00:38:06 +0000

This has been beaten to death in high quality randomized controlled trials in sepsis. Don’t believe a university press release lol. HN is a pretty poor source of health information overall.

New comment by et2o in "Sodium ascorbate treatment for sepsis moves to next phase of human trials"

et2o — Sat, 14 Oct 2023 00:36:17 +0000

This is a simplification. For example niacin (vitamin B3) excesses cause cholesterol to become more atherogenic. And supplementation in patients without deficiency is ultimately harmful.

New comment by et2o in "A DIY ‘bionic pancreas’ is changing diabetes care"

et2o — Thu, 31 Aug 2023 01:05:11 +0000

Your pancreas actually does know things like that you've ingested a lot of carbohydrates before they enter the bloodstream, etc. Certainly there is also a response to exercise that occurs before you coiod easily detect it with a CGM. There are very complex brain-gut-pancreas interactions mediated by a variety of molecules/hormones.

New comment by et2o in "A DIY ‘bionic pancreas’ is changing diabetes care"

et2o — Thu, 31 Aug 2023 00:57:40 +0000

> Hypoglycemia becomes symptomatic long before blood sugar is low enough to result in death or serious debilitation and T1D patients know their symptoms well.

Often times in an acute setting, yes. However patients who have had diabetes (T1 or T2) for a long time often lose a lot of their hypoglycemia sensitivity and symptoms. It's not nearly that simple.

New comment by et2o in "Superconductor news: What’s claimed, and how strong the evidence seems to be"

et2o — Thu, 27 Jul 2023 00:21:13 +0000

I believe that most of the lead used today is a by-product or co-product of mining other more valuable metals like Zinc and silver. Lead is quite abundant in the Earth's crust and found in easy to access deposits.

I think >80% of the current industrial use of lead is for batteries. It's probably still in the top ten most mined metals by dollar value and definitely by mass.

New comment by et2o in "Tea as Hepatoprotective Agent: A Revisit"

et2o — Fri, 07 Jul 2023 02:21:25 +0000

Fascinating. Thank you for sharing. I’m glad you were able to arrive at a diagnosis. I’m sorry to hear it was such an odyssey. I wonder how many other patients like you we are missing.

New comment by et2o in "Tea as Hepatoprotective Agent: A Revisit"

et2o — Thu, 06 Jul 2023 21:15:58 +0000

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.

New comment by et2o in "FedEx Accused of Largest Odometer Rollback Fraud in History with Used Vans"

et2o — Tue, 27 Jun 2023 13:25:24 +0000

It is not allowed prior to purchase

New comment by et2o in "Sony PlayStation 2 Development Kit (2020)"

et2o — Sun, 07 May 2023 00:16:06 +0000

What even is a developer MacBook? Any applied computer can be used

New comment by et2o in "The Most Efficient Car Ever Created? Mercedes EQXX [video]"

et2o — Sat, 21 Jan 2023 00:30:23 +0000

Interesting he calculates the theoretical maximum for efficiency will be around 260 MPGe

New comment by et2o in "Decolonization of the curriculum is the revenge of administrators"

et2o — Mon, 05 Dec 2022 18:36:11 +0000

Addressing his specific point that “decolonization” of the curriculum in medicine is “dangerous” - As a practicing physician, I strongly disagree. I think the author likely has a completely inaccurate idea of what a medical curriculum even is, as I cannot reconcile most of what he is saying with what I’ve seen at several of the top medical training places in the country. Decolonization of medical curriculum in general is important as our euro-centric view of disease often ends up dramatically hurting minority individuals. This runs from obvious things like making sure physicians have pictures of rashes on melanotic (dark) skin in textbooks to more difficult things like incorporating non-European ancestry individuals in massive genetic studies and not simply discarding their genetic info (as has been done for a lot of large population studies historically).

New comment by et2o in "Why Tesla removed radar and ultrasonic sensors [video]"

et2o — Mon, 31 Oct 2022 02:28:56 +0000

For the specific task of (for example) cooking a steak it’s not hard to envision a computer vision algorithm coupled with a model with a some basic knowledge of the system (ambient temperature, oven/stove temperature, time cooking, etc.) doing an excellent job.