I work on RNAi-based biopesticides (sprayed dsRNA) - non-GM, doesn't impact beneficial species, doesn't hang around in the environment, etc. Already ubiquitous in nature (and part of our diet). Peptide-based biopesticides are another approach that is going well. Both approaches are now commercialised by smaller players (e.g. for varroa mite control in bee hives by GreenLight), and not by the Bayer, Syngenta types.

https://population.un.org/wpp/graphs?loc=36&type=Probabilist...

Housing is very expensive, but inflation is largely tamed, unemployment is low, and the government is running surpluses - so things aren't terrible (despite what the Murdoch media say). Birth rates are falling, but I'm not sure how much that really matters given immigration.

I grew up in Australia with mutton making up 90% of my meat intake, as we slaughtered our own merino wethers (so not the breeds of lamb raised for eating).

The local butchers would also have a decent stock of different cuts, particularly things like neck chops for stews. Numbers of sheep around are lower now, so that may have limited things a little.

I also think hogget is equally as or more common than lamb in city butchers. Some of those chops are huge and have a nice tang.

- "Our work shows that TNT reprogramming is a practical and scalable approach to overcome these intrinsic characteristics of hiPS cells, which is important for the clinical delivery of this technology."

It's deep, but not too complicated that the learning curve is too much if you're time poor. Lots of hard choices to be made, which is always good in a decent RPG.

He's probably not as well known as someone like Gretzky in North America, so his name wouldn't immediately spring to mind on forums like this. In cricket, there just isn't any debate about the greatest - the only area of interest is about who comes next (Viv Richards or Brian Lara in my opinion)

Having said that, it's not my job, and I can see where the issues lay there.

Fungi are like plants. Some are beneficial. Some are not.

For example, the central dogma of DNA transcribed to RNA translated to protein seems simple, but it's not.

In almost every instance, there are vague 'rules' and many many exceptions to these rules. For example, often coding regions in genes start with an ATG, but sometimes they don't. Sometimes splice sites (where the non-coding parts of transcripts called introns are chopped out) can be predicted, but a portion of the transcripts are not spliced at predicted sites for no obvious reason. Sometimes the predictions are just wrong. Sometimes the generated proteins are modified at specific locations which impacts their function, but again, sometimes not. Even whether the gene itself is 'switched on' (i.e. able to be transcribed) is impacted by many many things, such as unidentified transcription factors, or whether the chromosomal location itself is accessible or not. There are many many other things that impact the process.

There is no simple underlying concept as the system is not designed, it evolved and is quite different among different organisms, and even in different tissues or timepoints in the same organism. As long as it works and provides enough benefit to avoid negative selection, that's enough.

It's a mess, which makes it interesting.

Genomics stretches vastly beyond this - assembly and annotation to start with.

I'd argue the most interesting problem space for software engineers is outside of what is covered in the document.

I’ve tasted wines 10x or 20x the price, and they really are no better. They likely cost exactly the same to make, but their price is impacted by demand.

In general, I think most people can tell a $10 bottle from a $30 bottle. I suspect very very few could reliably pick a $300 bottle from a $30 bottle.

When I got it, I was a healthy, fit person without any of the comorbidities that go along with COVID.

Last week I had a mountain biking accident and broke half my ribs and punctured a lung. Then I got COVID in hospital. Fortunately it was quite mild, and even that was a bit of a nightmare as coughing was hell and I had quite low blood oxygen.

Given the risks of a booster are so low (though non-zero) and the risk that your health can change before you manage to contract COVID, it seems like the smart proposition to me to get the booster.

https://www.carexpert.com.au/car-news/vfacts-australias-2021...

Tesla seem to have sold 12,094 locally last year, putting them at 18th on that list.

https://www.carsguide.com.au/ev/advice/how-many-teslas-are-t...

Australia with its long drives if you leave a city and lack of infrastructure doesn't suit electric cars at the moment. Will change eventually, but likely lagging the rest of the world.