<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: gwerbret</title><link>https://news.ycombinator.com/user?id=gwerbret</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Tue, 07 Jul 2026 06:51:25 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=gwerbret" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by gwerbret in "16-year-old SATA II SSD survives 1 petabyte of writes, 25x the drive's rating"]]></title><description><![CDATA[
<p>The article was written, from soup to nuts, by AI. I suspect the person who threw his byline on it barely glanced at the text.</p>
]]></description><pubDate>Sat, 20 Jun 2026 13:59:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=48609299</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48609299</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48609299</guid></item><item><title><![CDATA[New comment by gwerbret in "How much of Thermo Fisher's antibody data has been manipulated?"]]></title><description><![CDATA[
<p>Unfortunately, the equipment and reagent vendors in the very unregulated life sciences/biomedical research world constitute a racket. Serial buyouts over the last 10 - 15 years have led to a ridiculous degree of consolidation -- the sort that wouldn't fly in a regulated industry, or even one in which regulators are paying any attention at all -- so it's now dominated by two players: Merck (through its MilliporeSigma arm), and Thermo Fisher. The existence of this cartel means that they can essentially get away with murder, both from a fraud angle (which is exactly what the Western blot manipulation is) and by fixing prices to whatever degree they please.<p>Also unfortunately, biomedical scientists are not known for their tendency to collaborate to face a mutual enemy (the mild pushback against the Elsevier/Springer Nature publishing cartel has come less from scientists and more from university systems whose libraries have to foot most of the bills). From their perspective, it's "What am I gonna do? Raise my own antibodies? Start blowing my own glassware?" So they grimace and bear it.<p>For reference, here's how their workflow for research antibodies goes (and it's been like this for decades):<p>1. Produce an antibody the research world needs. Do no QA, that's expensive and unnecessary.<p>2. Claim with usually no evidence (and apparently by forging evidence) that the antibody works in certain applications.<p>3. Let researchers buy the antibody and do your QA for you. Even if the antibody doesn't work, only a tiny percentage of buyers will go to the effort of getting a refund.<p>4. Profit. Keep selling the antibody even when the rare scientist with time on their hands demonstrates beyond doubt that your antibody clearly doesn't work.<p>5. When sales start drying up because enough people are catching up to the scam, discontinue the antibody. Give no explanation.<p>6. Repeat from 1.</p>
]]></description><pubDate>Mon, 08 Jun 2026 23:42:46 +0000</pubDate><link>https://news.ycombinator.com/item?id=48454023</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48454023</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48454023</guid></item><item><title><![CDATA[New comment by gwerbret in "I was recently diagnosed with anti-NMDA receptor encephalitis"]]></title><description><![CDATA[
<p>NMDA receptor encephalitis is usually associated with a particular ovarian tumor, so the first thing I did on seeing this article was to check if the author is male or female (he's male). It is the habit of certain cancers to present with  bizarre symptoms (so-called paraneoplastic syndromes) including psychosis as in this case, and often it can be months before someone thinks to look for cancer. I'm glad the author's okay.</p>
]]></description><pubDate>Wed, 03 Jun 2026 19:10:05 +0000</pubDate><link>https://news.ycombinator.com/item?id=48388443</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48388443</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48388443</guid></item><item><title><![CDATA[New comment by gwerbret in "Why China got rich and India didn't"]]></title><description><![CDATA[
<p>> Can you elaborate? What's unique about the nations for which democracy isn't the best form of government? What's unique about their people?<p>Not the person you responded to, but functional democracies require either an already-established functioning government, which can be efficiently perpetuated and controlled by elected leaders (think the United Kingdom); or a non-functioning government which can be effectively reformed and then perpetuated by elected leaders (think Taiwan). In both cases, functional democracies also require an electorate who can be brought to work towards a nation's major development goals.<p>There are countries for which none of these criteria can be reasonably met in the context of a democracy. One reason is if the electoral processes are so corrupt that no one competent is actually elected or, if they are accidentally competent, are too busy working towards their own and their cronies' ends to be effective leaders. The second is if there is underlying social strife which prevents people from working collaboratively towards nation building.<p>India fails in both counts: the corruption at all levels of government is nothing short of legendary, and the country as a whole is comprised of very diverse peoples who, historically, have had little reason to work together. Many African countries, rather tragically, are in the same boat: during the colonial era, "countries" were almost randomly assembled out of groups of people who historically had almost nothing in common. When the colonial powers left, they typically left nothing behind -- no knowledgeable and experienced administrators, no established universal education, and little or no social infrastructure. The people were then left to reinvent government from scratch, and the "country" more often than not was actually five separate nations of people who hated each other.<p>In sum, democracy is sort of an advanced form of government which, when introduced, really does need a somewhat coherent nation to already exist (in more cases) for it to work well. An autocratic or authoritarian government is usually the on-ramp, so long as it's reasonably functional and stable for long enough. Wherever democracy has persistently failed to take off, it's invariably a place in which the underlying foundation didn't exist to begin with.</p>
]]></description><pubDate>Wed, 03 Jun 2026 08:35:12 +0000</pubDate><link>https://news.ycombinator.com/item?id=48381431</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48381431</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48381431</guid></item><item><title><![CDATA[Dear Google Cloud: Your Deprecation Policy Is Killing You (2020)]]></title><description><![CDATA[
<p>Article URL: <a href="https://steve-yegge.medium.com/dear-google-cloud-your-deprecation-policy-is-killing-you-ee7525dc05dc">https://steve-yegge.medium.com/dear-google-cloud-your-deprecation-policy-is-killing-you-ee7525dc05dc</a></p>
<p>Comments URL: <a href="https://news.ycombinator.com/item?id=48213103">https://news.ycombinator.com/item?id=48213103</a></p>
<p>Points: 5</p>
<p># Comments: 1</p>
]]></description><pubDate>Wed, 20 May 2026 19:46:48 +0000</pubDate><link>https://steve-yegge.medium.com/dear-google-cloud-your-deprecation-policy-is-killing-you-ee7525dc05dc</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48213103</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48213103</guid></item><item><title><![CDATA[New comment by gwerbret in "Project Gutenberg – keeps getting better"]]></title><description><![CDATA[
<p>Well, mainly in the fact that Anna's has several orders of magnitude more books, and includes research publications and more, ah, contemporary materials to boot.</p>
]]></description><pubDate>Sat, 16 May 2026 02:02:15 +0000</pubDate><link>https://news.ycombinator.com/item?id=48156123</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48156123</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48156123</guid></item><item><title><![CDATA[New comment by gwerbret in "Project Gutenberg – keeps getting better"]]></title><description><![CDATA[
<p>I love Project Gutenberg, don't get me wrong... but frankly, Anna's is better.</p>
]]></description><pubDate>Sat, 16 May 2026 00:16:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=48155558</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48155558</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48155558</guid></item><item><title><![CDATA[New comment by gwerbret in "Classification of amino acids"]]></title><description><![CDATA[
<p>Methinks someone's experimenting with a botnet -- "can we bypass HN's checks and balances to get an entirely-irrelevant topic to the front page, and keep it there for <i>x</i> hours?"</p>
]]></description><pubDate>Mon, 11 May 2026 18:17:49 +0000</pubDate><link>https://news.ycombinator.com/item?id=48098615</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=48098615</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48098615</guid></item><item><title><![CDATA[New comment by gwerbret in "Craig Venter has died"]]></title><description><![CDATA[
<p>Somewhat ironically, he'd spent the last years of his life working on prolonging life [1], and was selling a $25,000 "proactive healthcare service" consultation to anyone who could afford it [2].<p>1: The company's website, humanlongevity dot com, seems to have been compromised, and as "captcha" will try to have you install a Trojan. So here's the Wikipedia page instead: <a href="https://en.wikipedia.org/wiki/Human_Longevity" rel="nofollow">https://en.wikipedia.org/wiki/Human_Longevity</a><p>2: <a href="https://fortune.com/2017/02/21/craig-venter-human-longevity/" rel="nofollow">https://fortune.com/2017/02/21/craig-venter-human-longevity/</a></p>
]]></description><pubDate>Thu, 30 Apr 2026 03:03:35 +0000</pubDate><link>https://news.ycombinator.com/item?id=47957562</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=47957562</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47957562</guid></item><item><title><![CDATA[USB Cheat Sheet (2022)]]></title><description><![CDATA[
<p>Article URL: <a href="https://fabiensanglard.net/usbcheat/index.html">https://fabiensanglard.net/usbcheat/index.html</a></p>
<p>Comments URL: <a href="https://news.ycombinator.com/item?id=47904876">https://news.ycombinator.com/item?id=47904876</a></p>
<p>Points: 514</p>
<p># Comments: 87</p>
]]></description><pubDate>Sat, 25 Apr 2026 21:51:18 +0000</pubDate><link>https://fabiensanglard.net/usbcheat/index.html</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=47904876</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47904876</guid></item><item><title><![CDATA[New comment by gwerbret in "The End of Eleventy"]]></title><description><![CDATA[
<p>In case anyone wondered, the title is a play on the Isaac Asimov book "The End of Eternity":  <a href="https://en.wikipedia.org/wiki/The_End_of_Eternity" rel="nofollow">https://en.wikipedia.org/wiki/The_End_of_Eternity</a></p>
]]></description><pubDate>Sun, 12 Apr 2026 04:36:58 +0000</pubDate><link>https://news.ycombinator.com/item?id=47736198</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=47736198</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47736198</guid></item><item><title><![CDATA[New comment by gwerbret in "Show HN: BreezePDF – Free, in-browser PDF editor"]]></title><description><![CDATA[
<p>You've had enough arguments with people in both this thread and the previous that I'm pretty sure you understand what the issue is with your use of the word "free".<p>What you are offering is NOT a free tool -- it is a demo, for a tool for which you are charging $12/month. No reasonable person would interpret a grand total of 3 exports as enough to justify calling this a "free" tool.<p>This is to say nothing of your violation of AGPL on the use of MuPDF, which has been pointed out here and elsewhere.<p>But of course, you're free to Show HN a paid product; just kindly don't insult our collective intelligences in the process.</p>
]]></description><pubDate>Sun, 29 Mar 2026 22:20:12 +0000</pubDate><link>https://news.ycombinator.com/item?id=47568014</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=47568014</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47568014</guid></item><item><title><![CDATA[New comment by gwerbret in "Ensu – Ente’s Local LLM app"]]></title><description><![CDATA[
<p>As do most of the associated comments. I think we're surrounded by bots.</p>
]]></description><pubDate>Wed, 25 Mar 2026 14:22:53 +0000</pubDate><link>https://news.ycombinator.com/item?id=47517741</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=47517741</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47517741</guid></item><item><title><![CDATA[New comment by gwerbret in "Voxtral Transcribe 2"]]></title><description><![CDATA[
<p>I really wish those offering speech-to-text models provided transcription benchmarks specific to particular fields of endeavor. I imagine performance would vary wildly when using jargon peculiar to software development, medicine, physics, and law, as compared to everyday speech. Considering that "enterprise" use is often specialized or sub-specialized, it seems like they're leaving money on Dragon's table by not catering to any of those needs.</p>
]]></description><pubDate>Wed, 04 Feb 2026 18:19:15 +0000</pubDate><link>https://news.ycombinator.com/item?id=46889473</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46889473</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46889473</guid></item><item><title><![CDATA[New comment by gwerbret in "Geologists may have solved mystery of Green River's 'uphill' route"]]></title><description><![CDATA[
<p>The actual paper (open access): <a href="https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2025JF008733" rel="nofollow">https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/202...</a></p>
]]></description><pubDate>Mon, 02 Feb 2026 17:50:58 +0000</pubDate><link>https://news.ycombinator.com/item?id=46858900</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46858900</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46858900</guid></item><item><title><![CDATA[New comment by gwerbret in "Covid-19 mRNA Vaccination and 4-Year All-Cause Mortality"]]></title><description><![CDATA[
<p>> These are the important bits for the non medical folks<p>Also significantly: "vaccinated individuals consistently had a lower risk of death, regardless of the cause."</p>
]]></description><pubDate>Fri, 05 Dec 2025 16:00:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=46163060</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46163060</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46163060</guid></item><item><title><![CDATA[New comment by gwerbret in "Microsoft drops AI sales targets in half after salespeople miss their quotas"]]></title><description><![CDATA[
<p>A bit tangential and pedantic, but:<p>> At the heart of the problem is the tendency for AI language models to confabulate, which means they may confidently generate a false output that is stated as being factual.<p>"Confabulate" is precisely the correct term; I don't know how we ended up settling on "hallucinate".</p>
]]></description><pubDate>Thu, 04 Dec 2025 20:27:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=46152565</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46152565</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46152565</guid></item><item><title><![CDATA[New comment by gwerbret in "Migrating the main Zig repository from GitHub to Codeberg"]]></title><description><![CDATA[
<p>> I'm happy to see the move. Codeberg is probably a more stable/long-term solution than SourceHut as the founder is slightly unhinged<p>What's this about?</p>
]]></description><pubDate>Thu, 27 Nov 2025 02:22:43 +0000</pubDate><link>https://news.ycombinator.com/item?id=46064832</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46064832</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46064832</guid></item><item><title><![CDATA[New comment by gwerbret in "The Mozilla Cycle, Part III: Mozilla Dies in Ignominy"]]></title><description><![CDATA[
<p>Some thoughts regarding Mozilla's leadership.<p>Certain aspects of human nature, as they apply to the corporate world, can be acknowledged and understood, even if they're not excuses when they lead to the downfall of a prominent organization. When you give someone a big title, a dump truck full of cash, and a mandate to innovate, human nature dictates that most people will internalize the idea that "because I was given all this, I must be competent", even if they very obviously are not. Typically the outcome is a "bold plan forward" which is notable for lacking any actual clear solution to the company's main problems. In one example I know of, the CEO decided to pivot from an unrelated field towards launching a cryptocurrency, and cooked up a cartoonishly-dangerous marketing scheme to support the idea. One person ended up dying as a result, and the company then purged every mention of crypto from its website. (And yes, the company collapsed soon afterwards.)<p>While it's easy to blame the CEO with their oversized salary, the blame for such disasters doesn't just lie with them. After all, arguably the most important roles of the board are to hire a good CEO, ensure the CEO is actually performing as they should, and fire them if they're not. When politics, cronyism, or again, simple incompetence, lead the board to also fail at its job, you end up with the long, slow decline into obscurity we've seen so often in the tech world.<p>But Mozilla had a good run.</p>
]]></description><pubDate>Sun, 23 Nov 2025 00:53:21 +0000</pubDate><link>https://news.ycombinator.com/item?id=46019728</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46019728</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46019728</guid></item><item><title><![CDATA[Artificial Intelligence and Origin of Life Prize, $10M USD]]></title><description><![CDATA[
<p>Article URL: <a href="https://www.herox.com/evolution2.0">https://www.herox.com/evolution2.0</a></p>
<p>Comments URL: <a href="https://news.ycombinator.com/item?id=46019022">https://news.ycombinator.com/item?id=46019022</a></p>
<p>Points: 3</p>
<p># Comments: 0</p>
]]></description><pubDate>Sat, 22 Nov 2025 22:47:30 +0000</pubDate><link>https://www.herox.com/evolution2.0</link><dc:creator>gwerbret</dc:creator><comments>https://news.ycombinator.com/item?id=46019022</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46019022</guid></item></channel></rss>