Hacker News: hentrephttps://news.ycombinator.com/user?id=hentrepHacker News RSShttps://hnrss.org/hnrss v2.1.1Thu, 27 Aug 2026 08:54:01 +0000<![CDATA[New comment by hentrep in "FDA approves first in class targeted therapy for metastatic pancreatic cancer"]]>Comparing the acceleration of FDA approvals for non-contagious terminal diseases like PDAC to development of COVID vaccines is flawed on so many levels. You make it sound as though this was just cooked up in some desert meth lab RV over a weekend, and the FDA just rubber-stamped after a cursory glance at the data. The Phase 1/2 study first exploring daraxonrasib (RMC-6236) was posted on clinicaltrials.gov in May 2022; this trial enrolled 754 patients [0]. The RASolute 302 study this approval is based on was first posted to clinicaltrials.gov in October 2024; this trial enrolled 500 patients [1]. Nevermind the years of preclinical discovery and translational work that had to precede human studies.

As you can see from the control arm showing 6.7mo of survival on standard of care chemotherapy, these patients have a very poor prognosis. Is this a cure? No. Does it buy time to see your child graduate, get married, or give birth? Quite possibly.

If you ever have the opportunity to work behind the scenes within the pharma industry and/or FDA, you'd be astonished that anything ever gets approved with all the red tape and complexity along the way. Medicine is not software - it operates within the black box of human biology which is incredibly nuanced from patient to patient.

Like many who have shared personal stories in this thread, I've lost friends to PDAC. It is a terrible disease often driven by a mutated oncogene (KRAS). Many cancers have KRAS-driven subtypes (lung, colorectal, low-grade serous ovarian, etc). The clinical platform and pipeline at RevMed has potential to address many other cancers. They have next-gen RAS agents that could be even more impactful.

For those curious, RevMed posted a solid summary of the approval on their IR site [2]

[0] https://clinicaltrials.gov/study/NCT05379985?tab=researcher [1] https://clinicaltrials.gov/study/NCT06625320?tab=researcher [2]https://ir.revmed.com/static-files/0f7e4612-ad39-4c87-b266-8...

]]>Thu, 27 Aug 2026 00:25:51 +0000https://news.ycombinator.com/item?id=49457791hentrephttps://news.ycombinator.com/item?id=49457791https://news.ycombinator.com/item?id=49457791<![CDATA[New comment by hentrep in "FDA approves first in class targeted therapy for metastatic pancreatic cancer"]]>Beyond the data, this approval is notable for the speed from FDA acceptance of their new drug application (NDA) to FDA approval - just over a month. Compare this to the typical 8-12 month timelines we've historically seen for priority and standard reviews, respectively. This was enabled by the FDA's CNPV Pilot Program [0]

Previous discussion following the data presentation at ASCO: https://news.ycombinator.com/item?id=48517199

[0] https://www.fda.gov/industry/commissioners-national-priority...

]]>Wed, 26 Aug 2026 18:23:47 +0000https://news.ycombinator.com/item?id=49453559hentrephttps://news.ycombinator.com/item?id=49453559https://news.ycombinator.com/item?id=49453559<![CDATA[New comment by hentrep in "RevMed receives early FDA approval for 'groundbreaking' pancreatic cancer drug"]]>Beyond the data, this approval is notable for the speed from FDA acceptance of their new drug application (NDA) to FDA approval - just over a month. Compare this to the typical 8-12 month timelines we've historically seen for priority and standard reviews, respectively.

Previous discussion: https://news.ycombinator.com/item?id=48517199

FDA press release here: https://www.fda.gov/news-events/press-announcements/fda-appr...

]]>Wed, 26 Aug 2026 16:11:00 +0000https://news.ycombinator.com/item?id=49451557hentrephttps://news.ycombinator.com/item?id=49451557https://news.ycombinator.com/item?id=49451557<![CDATA[RevMed receives early FDA approval for 'groundbreaking' pancreatic cancer drug]]>Article URL: https://www.biospace.com/drug-development/revmed-receives-early-fda-approval-for-groundbreaking-pancreatic-cancer-drug

Comments URL: https://news.ycombinator.com/item?id=49451476

Points: 4

# Comments: 1

]]>Wed, 26 Aug 2026 16:05:09 +0000https://www.biospace.com/drug-development/revmed-receives-early-fda-approval-for-groundbreaking-pancreatic-cancer-drughentrephttps://news.ycombinator.com/item?id=49451476https://news.ycombinator.com/item?id=49451476<![CDATA[Neo]]>Article URL: https://hughhowey.com/introducing-neo/

Comments URL: https://news.ycombinator.com/item?id=49246066

Points: 3

# Comments: 0

]]>Mon, 10 Aug 2026 16:36:13 +0000https://hughhowey.com/introducing-neo/hentrephttps://news.ycombinator.com/item?id=49246066https://news.ycombinator.com/item?id=49246066<![CDATA[Hugging Face Incident Initial Post-Mortem]]>Article URL: https://cloudsecurityalliance.org/artifacts/hugging-face-ciso-post-mortem

Comments URL: https://news.ycombinator.com/item?id=49117191

Points: 1

# Comments: 0

]]>Thu, 30 Jul 2026 23:32:14 +0000https://cloudsecurityalliance.org/artifacts/hugging-face-ciso-post-mortemhentrephttps://news.ycombinator.com/item?id=49117191https://news.ycombinator.com/item?id=49117191<![CDATA[The secret Trump administration battle to fight Chinese AI]]>Article URL: https://www.axios.com/2026/07/20/ai-us-china-open-source-kimi

Comments URL: https://news.ycombinator.com/item?id=49002268

Points: 4

# Comments: 0

]]>Wed, 22 Jul 2026 05:38:28 +0000https://www.axios.com/2026/07/20/ai-us-china-open-source-kimihentrephttps://news.ycombinator.com/item?id=49002268https://news.ycombinator.com/item?id=49002268<![CDATA[AllTrails waypoints are now visible to everyone]]>Article URL: https://www.reddit.com/r/WildernessBackpacking/s/43tGNc3aEM

Comments URL: https://news.ycombinator.com/item?id=48837524

Points: 9

# Comments: 3

]]>Wed, 08 Jul 2026 21:15:19 +0000https://www.reddit.com/r/WildernessBackpacking/s/43tGNc3aEMhentrephttps://news.ycombinator.com/item?id=48837524https://news.ycombinator.com/item?id=48837524<![CDATA[Retraction questions claim that cancer therapy works better in morning]]>Article URL: https://www.science.org/content/article/retraction-questions-claim-cancer-therapy-works-better-morning

Comments URL: https://news.ycombinator.com/item?id=48693135

Points: 1

# Comments: 0

]]>Fri, 26 Jun 2026 23:03:39 +0000https://www.science.org/content/article/retraction-questions-claim-cancer-therapy-works-better-morninghentrephttps://news.ycombinator.com/item?id=48693135https://news.ycombinator.com/item?id=48693135<![CDATA[Bernie Sanders Wants a U.S. Sovereign Wealth Fund for AI]]>Article URL: https://www.forbes.com/sites/jamesbroughel/2026/06/22/bernie-sanders-wants-a-us-sovereign-wealth-fund-for-ai/

Comments URL: https://news.ycombinator.com/item?id=48668581

Points: 6

# Comments: 2

]]>Thu, 25 Jun 2026 03:41:44 +0000https://www.forbes.com/sites/jamesbroughel/2026/06/22/bernie-sanders-wants-a-us-sovereign-wealth-fund-for-ai/hentrephttps://news.ycombinator.com/item?id=48668581https://news.ycombinator.com/item?id=48668581<![CDATA[Lawsuit against Amazon over suicides linked to chemical can go to trial]]>Article URL: https://www.cbsnews.com/news/amazon-suicide-case-sodium-nitrite-washington-supreme-court/

Comments URL: https://news.ycombinator.com/item?id=48606282

Points: 9

# Comments: 0

]]>Sat, 20 Jun 2026 04:09:27 +0000https://www.cbsnews.com/news/amazon-suicide-case-sodium-nitrite-washington-supreme-court/hentrephttps://news.ycombinator.com/item?id=48606282https://news.ycombinator.com/item?id=48606282<![CDATA[I Am Rich]]>Article URL: https://en.wikipedia.org/wiki/I_Am_Rich

Comments URL: https://news.ycombinator.com/item?id=48470865

Points: 5

# Comments: 2

]]>Wed, 10 Jun 2026 03:01:56 +0000https://en.wikipedia.org/wiki/I_Am_Richhentrephttps://news.ycombinator.com/item?id=48470865https://news.ycombinator.com/item?id=48470865<![CDATA[New comment by hentrep in "Alzheimer's patient gets back speech, bladder control and memory in drug trial"]]>Here’s the original manuscript: https://www.frontiersin.org/journals/neuroscience/articles/1...

]]>Sat, 06 Jun 2026 02:20:26 +0000https://news.ycombinator.com/item?id=48420779hentrephttps://news.ycombinator.com/item?id=48420779https://news.ycombinator.com/item?id=48420779<![CDATA[Lithium Orotate Revisited (2025)]]>Article URL: https://www.science.org/content/blog-post/lithium-orotate-revisited

Comments URL: https://news.ycombinator.com/item?id=48417317

Points: 3

# Comments: 0

]]>Fri, 05 Jun 2026 19:51:46 +0000https://www.science.org/content/blog-post/lithium-orotate-revisitedhentrephttps://news.ycombinator.com/item?id=48417317https://news.ycombinator.com/item?id=48417317<![CDATA[YouTube Auto speed for premium members [video]]]>Article URL: https://www.youtube.com/shorts/P2cdhi1aSac

Comments URL: https://news.ycombinator.com/item?id=48377866

Points: 4

# Comments: 0

]]>Tue, 02 Jun 2026 23:56:13 +0000https://www.youtube.com/shorts/P2cdhi1aSachentrephttps://news.ycombinator.com/item?id=48377866https://news.ycombinator.com/item?id=48377866<![CDATA[China blocks Meta from acquiring AI startup Manus]]>Article URL: https://apnews.com/article/china-meta-manus-ai-acquisition-5f8012791f86f719a24a3ebac06d9b0a

Comments URL: https://news.ycombinator.com/item?id=47924754

Points: 5

# Comments: 0

]]>Mon, 27 Apr 2026 17:40:56 +0000https://apnews.com/article/china-meta-manus-ai-acquisition-5f8012791f86f719a24a3ebac06d9b0ahentrephttps://news.ycombinator.com/item?id=47924754https://news.ycombinator.com/item?id=47924754<![CDATA["Game-changer" breast cancer study retracted as researcher out of his post]]>Article URL: https://retractionwatch.com/2026/04/15/game-changer-breast-cancer-study-retracted-as-indiana-researcher-out-of-his-post/

Comments URL: https://news.ycombinator.com/item?id=47901567

Points: 3

# Comments: 0

]]>Sat, 25 Apr 2026 13:52:05 +0000https://retractionwatch.com/2026/04/15/game-changer-breast-cancer-study-retracted-as-indiana-researcher-out-of-his-post/hentrephttps://news.ycombinator.com/item?id=47901567https://news.ycombinator.com/item?id=47901567<![CDATA[Finra Adopts New Standards to Replace the Day Trading Margin Requirements]]>Article URL: https://www.finra.org/rules-guidance/notices/26-10

Comments URL: https://news.ycombinator.com/item?id=47877321

Points: 2

# Comments: 1

]]>Thu, 23 Apr 2026 15:56:41 +0000https://www.finra.org/rules-guidance/notices/26-10hentrephttps://news.ycombinator.com/item?id=47877321https://news.ycombinator.com/item?id=47877321<![CDATA[Police officer uses Flock database to track mistress]]>Article URL: https://ktla.com/news/orange-county/former-orange-county-officer-pleaded-guilty-to-using-police-database-to-track-mistress-harassing-her-with-thousands-of-texts-and-phone-calls/

Comments URL: https://news.ycombinator.com/item?id=47774402

Points: 55

# Comments: 4

]]>Wed, 15 Apr 2026 03:33:53 +0000https://ktla.com/news/orange-county/former-orange-county-officer-pleaded-guilty-to-using-police-database-to-track-mistress-harassing-her-with-thousands-of-texts-and-phone-calls/hentrephttps://news.ycombinator.com/item?id=47774402https://news.ycombinator.com/item?id=47774402<![CDATA[New comment by hentrep in "Hong Kong / China / Taiwan Based Slack Suspended"]]>Seems related (though 2 months delayed) to this announcement: https://news.ycombinator.com/item?id=45961157

]]>Thu, 02 Apr 2026 14:41:04 +0000https://news.ycombinator.com/item?id=47615166hentrephttps://news.ycombinator.com/item?id=47615166https://news.ycombinator.com/item?id=47615166