Hacker News: highfrequency

New gene delivery vehicle shows promise for human brain gene therapy

highfrequency — Thu, 28 May 2026 19:40:56 +0000

Article URL: https://www.broadinstitute.org/news/new-gene-delivery-vehicle-shows-promise-human-brain-gene-therapy

Comments URL: https://news.ycombinator.com/item?id=48314347

Points: 6

# Comments: 0

Enlicitide lowers LDL by 60% with little side effect

highfrequency — Wed, 27 May 2026 16:43:59 +0000

Article URL: https://apnews.com/article/cholesterol-merck-enlicitide-ldl-statin-pcsk9-f7383ce62b2e406841fbe6303fac6b20

Comments URL: https://news.ycombinator.com/item?id=48296860

Points: 16

# Comments: 0

Ambrose to Theodosius I 390

highfrequency — Tue, 19 May 2026 21:54:12 +0000

Article URL: https://sourcebooks.web.fordham.edu/source/ambrose-let51.asp

Comments URL: https://news.ycombinator.com/item?id=48200191

Points: 2

# Comments: 0

New comment by highfrequency in "Cursor Introduces Composer 2.5"

highfrequency — Tue, 19 May 2026 14:54:54 +0000

> now they’ve thrown down the gauntlet directly challenging frontier labs by training their own model (“much larger” than Kimi 2.5’s 1T parameters) from scratch.

To clarify, the model Composer 2.5 announced in this post is not that; it uses Kimi 2.5 as a strong starting point. This is not to discount Cursor's work or future ambitions, but one of the most striking things about the last 6 months is that multiple open-source models/labs are now within striking distance of the frontier closed-sourced labs.

See eg Kimi 2.6 benchmarks: https://www.kimi.com/blog/kimi-k2-6

Keats, Letters

highfrequency — Sat, 09 May 2026 21:49:09 +0000

Article URL: https://sites.ualberta.ca/~dmiall/Tintern07/KeatsLet.htm

Comments URL: https://news.ycombinator.com/item?id=48078597

Points: 2

# Comments: 0

New comment by highfrequency in "A recent experience with ChatGPT 5.5 Pro"

highfrequency — Sat, 09 May 2026 17:50:59 +0000

> LLMs have got to the point where if a problem has an easy argument that for one reason or another human mathematicians have missed (that reason sometimes, but not always, being that the problem has not received all that much attention), then there is a good chance that the LLMs will spot it.

New comment by highfrequency in "When everyone has AI and the company still learns nothing"

highfrequency — Tue, 05 May 2026 16:05:10 +0000

What’s wrong with the finance team (vibe) coding a janky prototype for planning?

Main quests, subquests, side quests and minigames

highfrequency — Thu, 30 Apr 2026 17:50:46 +0000

Article URL: https://stevepavlina.com/blog/2020/02/main-quest-subquest-side-quest-or-minigame/

Comments URL: https://news.ycombinator.com/item?id=47965954

Points: 1

# Comments: 0

New comment by highfrequency in "Tim Cook's Impeccable Timing"

highfrequency — Tue, 21 Apr 2026 15:17:43 +0000

Why do you prefer the laptop to be thicker and heavier?

New comment by highfrequency in "Measuring Claude 4.7's tokenizer costs"

highfrequency — Fri, 17 Apr 2026 18:59:33 +0000

I believe that's why 90% of the focus in these firms is on coding. There is a natural difficulty ramp-up that doesn't end anytime soon: you could imagine LLMs creating a line of code, a function, a file, a library, a codebase. The problem gets harder and harder and is still economically relevant very high into the difficulty ladder. Unlike basic natural language queries which saturate difficulty early.

This is also why I don't see the models getting commoditized anytime soon - the dimensionality of LLM output that is economically relevant keeps growing linearly for coding (therefore the possibility space of LLM outputs grows exponentially) which keeps the frontier nontrivial and thus not commoditized.

In contrast, there is not much demand for 100 page articles written by LLMs in response to basic conversational questions, therefore the models are basically commoditized at answering conversational questions because they have already saturated the difficulty/usefulness curve.

Lessons from Building Mercury

highfrequency — Thu, 16 Apr 2026 19:18:42 +0000

Article URL: https://www.thespl.it/p/the-future-of-banking-remote-work

Comments URL: https://news.ycombinator.com/item?id=47798177

Points: 1

# Comments: 0

The Dynamics of Competition in Search Engines (2001)

highfrequency — Wed, 15 Apr 2026 21:35:03 +0000

Article URL: https://www.tesble.com/10.1016/s0167-7187(01)00065-0

Comments URL: https://news.ycombinator.com/item?id=47785574

Points: 1

# Comments: 0

New comment by highfrequency in "The economics of software teams: Why most engineering orgs are flying blind"

highfrequency — Mon, 13 Apr 2026 15:58:42 +0000

Agreed, but are you also implying that the process of iteratively "programming something that's not it, and then replacing it" multiple times is not in the scope of what LLMs can/will do?

New comment by highfrequency in "System Card: Claude Mythos Preview [pdf]"

highfrequency — Tue, 07 Apr 2026 23:35:24 +0000

Interestingly, non-coding improvements seem less clear. In the Virology uplift trial, Mythos does about as well as Opus 4.5, and Opus 4.6 is notably much worse than Opus 4.5 (p. 27).

Project Mario: the inside story of DeepMind

highfrequency — Tue, 31 Mar 2026 15:18:40 +0000

Article URL: https://colossus.com/article/project-mario-demis-hassabis-deepmind-mallaby/

Comments URL: https://news.ycombinator.com/item?id=47588632

Points: 17

# Comments: 1

Stackelberg Competition

highfrequency — Fri, 27 Mar 2026 19:39:11 +0000

Article URL: https://en.wikipedia.org/wiki/Stackelberg_competition

Comments URL: https://news.ycombinator.com/item?id=47547253

Points: 3

# Comments: 0

I Created Rosie's mRNA Vaccine

highfrequency — Fri, 27 Mar 2026 19:33:58 +0000

Article URL: https://twitter.com/paul_conyngham/status/2036940410363535823

Comments URL: https://news.ycombinator.com/item?id=47547198

Points: 4

# Comments: 1

Hummingbird: Venture Firm You've Never Heard Of

highfrequency — Fri, 27 Mar 2026 19:12:18 +0000

Article URL: https://www.generalist.com/p/hummingbird

Comments URL: https://news.ycombinator.com/item?id=47546970

Points: 2

# Comments: 0

New comment by highfrequency in "The bridge to wealth is being pulled up with AI"

highfrequency — Tue, 24 Mar 2026 16:24:35 +0000

"The window described above is not a metaphor. It is an arithmetic deadline...The window is not a metaphor for someone at your coordinates. It is a number."

9 to 1 bet that this is written by AI (perhaps proving the writer's point that he is being displaced).

I think AI is great, but I wish people would just post the prompt they gave instead of the full length decompressed essay. Much more efficient information transfer!

New comment by highfrequency in "An unsolicited guide to being a researcher [pdf]"

highfrequency — Mon, 23 Mar 2026 16:26:23 +0000

“Your objective is to find the weirdest niche possible that still has the potential to change everything.”

“Virality based social media is inherently homogenizing.”

Some nice nuggets in here!