The following is text of an email to the only person I know, my mother:

9 years of living homeless is enough. I have no purpose and no future. I have to stop idling and face reality. I have nothing, am nothing, provide nothing, can’t interact with people and offer nothing. I’m tired of all of it. I don’t have anything to do and refuse to do pointless “painting for dementia patients” meaningless “work” that doesn’t change anything. I can’t think of anything worth doing, I can’t think anymore (cognitive decline) and I don’t have any means to do anything if I did. It’s not your fault, it’s bad genetic dice and my fault for where I’m at. My mind is failing, my health is failing in multiple ways and I can’t keep delaying the inevitable.

I wish this didn’t have to be so but wishing doesn’t help the facts. I’m a parasite whose lifecycle needs to expire sooner rather than later, so you must let me go. There is no viable alternative that I can think of that I could live with. I don’t want to live in this failing world anymore and I’m failing too. There’s nothing for me here or anywhere. I can’t build anything, I can’t do anything, I can’t have friends, I can’t have a family... so I don’t want to live.

It’s over.

Comments URL: https://news.ycombinator.com/item?id=17386411

Points: 32

# Comments: 16

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    #ifdef __cplusplus
    }
    #endif
    #endif /* SUCCESSFUL_H_ */

The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.

2.3 Metabolites

The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.

(Table 1 - 22 metabolic variables considered)

https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095

I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.

PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr

- Object contains a Class that it derrives from (no BaseObject or Modules)

- Class is an Object

- String is an Object

- Boolean is a two-value singleton of true and false

- Number is an abstract subclass of Object

- Decimal and Integer are abstract subclasses of Number

- Float, Double, LongDouble, BigDecimal are concrete subclasses of Decimal

- SignedByte, Byte, Short, UnsignedShort, Int, Unsigned, Long, UnsignedLong, Char, BigInt are concrete subclasses of Integer (or U/I/F## types reminiscent of Rust instead of C type names)

and so on.

Then there is no boxing/unboxing of simple types or literals because they are one-and-the-same, and no there’s no confusion about how to interact with any truly generic type of value.

https://www.ftb.ca.gov/individuals/use-tax.shtml

https://www.cdtfa.ca.gov/taxes-and-fees/use-tax.htm

Another fail is “recycling” at Costco, where basically no recycling happens and people just throw things in carelessly into any of the 3 bins. Worse, the staff contribute to its demise equally by eliminating the sorting signs and turning bins around to hide their labeling. Red, green, blue ... go figure which is which.

It’s not just fertility that declines, but IQ and a rise in birth defects.

It’s the opposite of virtue-signaling if you live and work for what’s right, not out of what’s most expedient or wins popularity points, but out of integrity. Too few people these days have the courage to think deeply and act consistently regarding the big issues impact of their choices of consumption, associations and work income. (Focusing too much on tiny issues would exclude everyone.)