This is called working! I am struck by the double-standard applied to assessing treatment options for Alzheimer's vs cancers. Many (most?) Stage IV cancers are incurable, and the main goal of treatment is to slow progression of the disease. Adding years to patients' lives is absolutely worth it, assuming the side effects are not overwhelming and the costs are not prohibitive.

To wit: Moderna added ~30B to its market cap on the news that it observed _statistically significant_ improvement in its primary endpoint for treating metastatic melanoma. Great! I'm as excited about this development as anyone. A new treatment option for a terrible disease that meaningfully improves on the current standard of care (Keytruda). Sadly, Stage IV melanoma is still considered terminal, and no one suggested that Moderna changed that.

Why not reset expectations for Alzheimer's? If we manage to slow its development enough so that most patients (who tend to be elderly) would die of other causes while maintaining decent quality of life, that's a win in my book.

Comments URL: https://news.ycombinator.com/item?id=48500751

Points: 2

# Comments: 1

I venture a wild guess that the somewhat implausible "Yaroslav Murai" is a pseudonym, up there with Satoshi Nakamoto.

These are not mutually exclusive statements. Actually, this is how Ponzi schemes work ; -)

(Somehow I never connected Bayer et al. and Bayer & Diaconis. Wow!)

Do I trust the government to police opinions? No, especially when there's no accountability and appeals process.

Do I believe the overall benefits that harassment-free international travel brings to this country outweigh the costs of letting in some visitors whose views I disagree with? Yes.

I'm looking at the official statistics, and this is not what they say:

The government pension is the main source of income for 47% of retirees vs superannuation's 33%. Moreover, the proportion of those relying on the pension has increased between 2020 and 2022 by 3 pts.

https://www.abs.gov.au/statistics/labour/employment-and-unem...

For better or worse, anecdotes of the caviar delivered by the crates to the top party officials appear in many Russian sources. I don't know whether independent historians confirmed these stories but they are believed by many. For very good reasons, since this is what the party did all along - it's the brutal conditions outside the party HQ in Leningrad that make these anecdotes especially poignant.

> Also, once the soviets repelled the german attack on moscow, didn't the soviets liberate leningrad?

Not until more than two years later. (It was not for the lack of trying - in 1942 an unsuccessful operation led to a complete loss of two full armies.)

As a practical matter, since dealing in mutual funds' shares is settled after market, "front running" these transactions would be problematic. (Impossible, I'd say?)

Comments URL: https://news.ycombinator.com/item?id=42619652

Points: 557

# Comments: 97

The most powerful primitive that the dialect has is (mutual) recursion, which is effectively a mechanism for outputting a fixed-point of a query.