“Don’t do X” is just as useful as telling an infant not to cry.

When an infant cries, we implicitly understand there is a form of discomfort to address (food, diaper, etc).

To me, when a LLM fails, it signals to me that the architecture and structure of the code is problematic and that needs to be addressed.

Any seasoned dev can usually see non-DRY, non-KISS patterns, then will structure an encapsulation around said pattern to address issues.

I’ve found that this same type of refactoring is needed in LLM code to improve its outcomes, of which then it’s capable of overcoming the bugs.

Simply telling the LLM to refactor for cleanliness in between code generation runs will do so much for maintainability.

I went the same way with simply bumping up my bash skills.

Part of me feels like I'd prefer pry loaded with a library that provides shell like methods for doing ruby-esque things.

Then there's confounders like altitude, elevation gain that can sully the numbers.

It can be pretty great, but it needs a bit of control in order to get a proper reading.

I doubt that folks with a solid diet, high in sulfur would find much benefit from NAC.

However, as someone who's gotten to use it first hand and have dealt with lifelong, mild inflammation (puffy fingers, clogged nose here and there), it's definitely been a huge quality of life enhancer.

There are some basic, well-known nutritional interventions that are generally important/critical for DNA repair processes. The 2 main ones are Vitamin D and Magnesium. Ensuring adequate amount of these tend to be helpful (most folks aren't getting enough sun and greens).

Other than that, a steady and adequate source of the substrates seems to be important: ie protein (nitrogen), and phosphates.

One of the interesting bits about some cancer cells is that while they simply haven't gone through apoptosis, physical sheer stress incurred from physical activity (exercise) can cause cancer cells that travel beyond the tumor point (before it becomes metastatic) to finally self destruct.

It seems important to me that the best strategy for cancer is the compounding of many different strategies that optimize the body's innate defenses to run optimally.

It does seem that ketogenic diets may have adjuvant properties, but there is yet to be a clinical trial that demonstrates it, so it's basically stuck in paper and R&D stages as to whether being in a ketogenic state can be one of the last areas that may help cancer patients extend lifetime from say 1 year to 2 years.

Though, to be play devil's advocate for a second, it does seem that diabetes is typically where the symptoms start, and we do understand that diabetes is fundamentally metabolic and/or functional dysfunction in 1 or more of 7-ish different areas.

I think it's the level of perspective zoom + timing we take that makes the article's assertion either useful or not.

If we zoom out, while catching disease early on, and we address the metabolic conditions via lifestyle and/or certain drugs like GLP1, then we prevent the need to intervene on the kidney and cardiac front.

But if we zoom in to a specific issue, after disease has progressed a profound amount, a GLP1 intervention may be too little, too late.

Hopefully though, this may help the messaging to folks that if they are contending with metabolic disease that presents as diabetes, introducing lifestyle and pharma interventions early may be helpful on the larger epidemiological front.

Slower absorption in the thigh may blunt the immediate peak dosing and the acute hunger effects.

As always, the small details matter. I'd guess that pharmacology also has their own thundering herd problem with the dosing of certain drugs.

One of the interesting bits about pharmacology seems to not be the active molecule as much as the innovations in delivery mechanism.

Usually this type of anecdata becomes the basis of legitimate, controlled studies and over time can inform and/or adjust.

It would be premature to simply write off all influencers or limiting to only accept the medical profession as the immutable truth.

The reality tends to exist somewhere in the middle, outside of a formal proof.

I've listened to many health influencers and among the legitimate and balanced tend to be Rhonda Patrick and Peter Attia.

Attia provides guidelines for how to think about items, but usually it's the fan base that tends to sully the messaging as the base tends to be far more polarized and dogmatic over bits.

It is interesting to see that there is another poster confirming a slightly different effect though. Regardless of things being "systemic", just understanding that fluids dynamics are complex, I imagine diffusion of a systemic molecule like GLp1 could possibly be variable? Or perhaps there is a localized tissue fatigue?

Many potential options do exist to propose as hypothesis.

He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss.

They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects.

It seems like GLP1, even in skinny patients (implied by Attia in this particular case), has metabolic benefits.

The longevity community seems to be hinting that there may be geroprotective aspects of GLp1 as well, so we may be looking at the benefits beyond weight loss for metabolism.

I do a 32hr fast once a week and will consume a scoop of psyllium when I get hungry and it's quite filling for 2-3 hours before the hunger kicks back in.

While I can’t speak directly to this, but from watching The China Show on YouTube, the tradeoff to the amazing amenities is that the personal-injury risk from failing infrastructure has been fatal, but covered up by their propaganda. Anyone on the receiving end of it, will deal with devastating consequences, if not fatal.

Infrastructure and manufacturing corners are cut in ways that look great, but literally kill their population and tourists.

Building foundations are not thick enough, buildings aren’t built to proper fire safety standards, underground pipes leak, leading to roads constantly failing, high rises burn down, sewage pipes literally blow up due to methane build up like someone detonated a bomb.

Drainage grates are fake and flooding cities, drowning people in vehicles, while the QA of car battery manufacturing is causing electric fleets of cars in parking lots to burn.

And the aforementioned occurrences are happening in tier1 cities.

I sound hyperbolic, but China is great at quickly cleaning up and quickly rebuilding, so it doesn’t seem nearly as bad as it does.

Once I learned about the infrastructure, I realized my cousin’s business trip accident in China was not a randomly rare accident.

He broke his back in China when his rental car’s front wheel popped off the car.

Chances are most folks are fine if they go. But I would be very weary, because the probability of a disaster is not nearly as high as it ought to be.

Seems to help to create systems that let us fall to the level of compliance we desire.

The world has been watching for over 2 years the atrocities occurring in Gaza and Israel and its people have has lost its credibility to its victimhood on the world stage.

This article is simply 1 extra reporting on a million of Israel’s offenses in the name of terrorism.

The reasoning for this is action about nuclear weapons programs. Israel gets to have nukes, developed by sending US expertise to Israel, while Israel has not been subject to nuclear investigation programs.

If things ever got bad, the US doesn't want to nuke the world, then face retribution, they want Israel to shoulder that burden.

It's a cop out and putting one's head in the sand to the real atrocities of zionistic ambitions of usurping Palestinian land.

In America, if someone trespasses into one's home and the home owner kills the trespasser, the vast majority of the time, the owner is justified and there are numerous court cases we can point to. Recently, it has become clear to me that Palestinians are simply trying to defend their own property/land/humanity.

Israel's trespasses are finally seeing the light in the latest set of conflicts and folks reading this comment that are unsure should spend 30 minutes looking up the videos of the conflict.

Israel blocking aid, murdering medical personnel with impunity, the before/after of Gaza, the list of crimes perpetuated by the government is undeniable at this point.

As a random bystander with no real skin in this conflict, other than being American, what I can say is that for a while, it did seem that Israel the country had to unfairly deal with hate and war and it seemed quite unfortunate.

Most of the horrifying stories that would occasionally rise up seemed unbelievable, if not overblown.

Though in recent weeks, social media & news has provided another perspective.

1. Numerous Israeli citizens mocking Palestinians and having the gall to upload it to social media.

2. Numerous classrooms and children being taught that non-Israeli's do no deserve the same human rights as Israelis, and the children from a young age reveling in their superiority.

3. Videos showing citizens in normal cars being a nuisance to Palestinian medical vehicles.

4. Videos showing the absolute decimation of Gaza.

5. Israeli news articles reporting 70% and more of the population supporting certain war actions.

6. Ex-IDF soldiers whistleblowing the atrocious acts they needed to commit.

7. Citizens barbequing and hanging out right along the Gaza's border as Palestinian folks on the other side starve.

8. The video of Palestinian medics getting murdered on the side of the highway.

9. Pictures of the logos on IDF uniforms showing "our promised land" with a map showing borders that claim the land of Egypt, Syria, Palestine, Iraq, Lebanon.

I don't think there is something "broken" in aid delivery. It appears that there is a systemic and concerted effort by the bulk of the government and citizens (100% of who have to serve in the IDF) to colonize and usurp Palestinian land and beyond.

And it seems that the latest set of conflicts have pulled back the curtain on the attitudes held by both the Israeli citizens and government.

Makes it nice and easy for the non-technical members of the fam.