Comments URL: https://news.ycombinator.com/item?id=47247594

Points: 1

# Comments: 0

I've found vextab [1] though it doesn't seem to be maintained anymore, and of course there are plenty of ASCII-art formats (GuitarPro et al) though these are really renderers, not markup (in other words, I want to _generate_ renders, not have to type them).

LilyPond [2] is neat, but of course much too verbose to jot down in semi-realtime.

I've started writing a language spec [3] and renderer [4], but surely someone else has had this idea before??

```catl # chords: X554X5 ```

```catl # tabs: # ↓chord 0A 0D 5e 7B 3e+0D ```

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[1] https://vexflow.com/vextab/tutorial.html [2] https://lilypond.org/ly-examples/tab-example.ly [3] https://github.com/j6k4m8/catl [4] https://github.com/j6k4m8/catl-render

Comments URL: https://news.ycombinator.com/item?id=46488963

Points: 1

# Comments: 0

[1] https://blog.jordan.matelsky.com/AI-doctors-bum-me-out/

blueblocks gives you letters and assigns points for the _bounding box_ of your valid-words solution; smaller area is better!

every day has a "perfect" dense solution... NYT-style, mondays are easiest, sat-sundays are hardest!

feedback welcome! hope you enjoy :)

Comments URL: https://news.ycombinator.com/item?id=45618572

Points: 3

# Comments: 0

    pip install 'git+https://github.com/j6k4m8/frof/'

    frof myfile.frof

Was thinking about rewriting it in Go recently... :)

Here's another illustrative example:

    A -> B
    B -> C
    Z -> C

So for a file with those contents called `mygraph.frof`, you can (after installing) run `frof mygraph.frof` to kick off the jobs in the current shell (inheriting env vars etc).

[edit] maybe a clarifying example here: https://blog.jordan.matelsky.com/frof-render/

Designed to be ultra-simple and with minimal "config-file acrobatics".

It looks like this [edit, formatting]:

    write -> analyze
    build -> analyze

    write:     echo 1 2 3 > data.txt
    build:     compile_tool.sh > tool.sh
    analyze:   tool.sh data.txt

More nitpickfully, one of the big things we care about is if the bacteria are living _harmlessly_ in the brain. i.e., site of microbes, and a lack of inflammation, will answer more than just "are there microbes around".

We're lucky to live in a scientific era during which a "gut microbiome" is taken for granted (heck, even FDA-approved treatments depend on it! Google FMT, but don't click "images" from your work laptop), but it wasn't so long ago that we felt microbes were unlikely to live endogenously and harmlessly anywhere in the body.

There were also some hypotheses (untested, if memory serves) that COVID-19 influenced olfactory neurons through direct infection. Don't tell the blood-brain barrier, but if I were a bacterium, the nasal palate would be my ingress strategy. Or maybe the gums or gut — one of the cranial nerves, certainly. [edit] I should clarify — covid is viral, not bacterial, but it does show that this is a potential entry vector.

The central nervous system is incredibly complicated, and our symbiotic relationship with microbes is extraordinary. I think it does a disservice to bacteria to suppose they DON'T get involved in an organ :)

[1] https://www.space.com/ryugu-asteroid-sample-earth-life-colon...

I STRONGLY believe there is a substantial central nervous system microbiome, but (spoiler alert) no evidence found in that search :)

If you're excited about this work, the datasets are all freely available from BossDB [2] — well over a dozen petavoxels of it! I'd be so curious if models these days could pick up on something we missed!

[1]: https://www.biorxiv.org/content/10.1101/2022.07.12.499807v1 [2]: https://bossdb.org

i'm not hosting this dataset specifically, but check out https://bossdb.org/. my disclaimer and also my brag is that this is my job and research area :) if you're looking for a copy, let's talk! there are easy ways and hard ways :)

in the meantime, here's a simple tool paper we wrote explaining how you can treat this like a cool graph database challenge [1] and a preprint showing how you could approach that question when your number of samples per animal is close to N=1 [2]. basically..... it's hard! but also.... it's cool!

[1]: https://www.nature.com/articles/s41598-021-91025-5 [2]: https://www.biorxiv.org/content/10.1101/2023.10.16.562590v1....

I've been hoping to write my own now that the dust has settled, but it's definitely a MAJOR project yet to be done by the FOSS community.

[1] https://news.ycombinator.com/item?id=41437740