Comments URL: https://news.ycombinator.com/item?id=47022547

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https://data.energizer.com/pdfs/l91.pdf

https://www.medtronicdiabetes.com/sites/default/files/librar...

I can't think of any good applications for conventional NiMH cells any more - they're dominated by LSD NiMH cells in low-discharge applications, by lithium primary cells in ultra-low-discharge applications and by the various lithium secondary chemistries in high-discharge applications.

The entire problem is that most people in high- and middle-income countries are in fact doing something blatantly wrong - they are consistently eating vastly more calories than they use. Some of those people are ignorant of what 2000 to 2500 calories actually looks like, some are deluded, but a very large proportion know damned well that they're eating far too much and do it anyway.

The obesogenic environment that we now live in is partly due to the influence of the processed foods industry, but in large part it's simply a product of abundance. Before the late 20th century, it was simply inconceivable that poor people could afford to become morbidly obese. Agricultural productivity has improved beyond all recognition and the world is flooded with incredibly cheap food of all kinds.

We've spent the last few decades trying to push back against that with all manner of initiatives intended to endgender behavioural change, with very little success. It doesn't really matter what guidance we give people when they have shown a consistent inability or unwillingness to follow it.

If we're actually serious about the effects of diet on public health, I think there are only two credible options - extremely heavy-handed regulation, or the mass prescribing of GLP-1 receptor agonists. All of the other options are just permutations of "let's do more of the thing that hasn't worked".

The existence of such a large and conspicuous secret might seem bizarre to the post-cold-war mind, but it was fairly common in the West too. For example, the British Telecom Tower in central London stands at 189 metres tall and had a revolving restaurant that was open to the public, but was also a designated site under the Official Secrets Act.

Good governance is hard.

If you're looking for a sinister plot, look no further than In-Q-Tel.

Personally, I think that Copilot for Work is a good product that does useful things. I use it daily. It isn't particularly groundbreaking, but it's nicely integrated with the wider 365 ecosystem and it has saved me a bunch of time on tedious tasks. The usual LLM caveats apply, but I just don't get why someone would be so annoyed by an entirely optional feature.

Lobotomy was in fact an effective treatment (albeit with extremely severe side-effects), but we now have much better and safer treatments available. The abandonment of lobotomy was fundamentally driven by the invention of effective antidepressants, antipsychotics and mood stabilisers. Neurosurgery is still offered to an extremely small proportion of patients suffering from very severe and treatment-resistant depression and OCD.

https://www.cambridge.org/core/journals/bjpsych-advances/art...

Bluntly, if someone is capable of actually starting and sticking with an exercise routine, then they aren't very depressed and should not be offered medication as a first-line treatment. Antidepressants are markedly less effective in patients with milder illnesses, so psychotherapy and lifestyle interventions are a far better initial treatment option. It's only when these treatments fail - or when engaging with them is severely impaired by the severity of the illness - that medication becomes the favoured option.

One of the key diagnostic criteria for melancholic depression - what we might lazily and inaccurately call biological or "real" depression - is mood unreactivity. Someone with severe melancholic depression could win the lottery one week, lose all of their family in a plane crash the next, and feel literally nothing about either event.

Some people with atypical depression (or normal sadness that has been mis-diagnosed as depression) can respond rapidly and dramatically to a change in their circumstances. For many others with depression, there is no external why - something has gone fundamentally wrong in the functioning of their brain. Trying to help those people with talk therapy or exercise or companionship would be as futile as using those things to treat hepatitis or gangrene.

Some people would rather believe that pediatric depression isn't real, rather than confront the reality of a loved and cared-for child who is constantly tearful, severely underweight, sleeps for three or four hours a night, spends most of their time staring into space and frequently talks about wanting to die.

Depression is an utterly dreadful illness and should not be confused with normal sadness or unhappiness.

>once I noticed it also affected my ability to experience color

A small amount of evidence does support the notion that depressed people literally see the world as being less vibrant.

https://pubmed.ncbi.nlm.nih.gov/34689697/

https://cdnsciencepub.com/doi/10.1503/jpn.200091