Psilocybin is a more selective 5-HT2A agonist than LSD and is more rapidly metabolised. At normal recreational or clinical doses, they really aren't very different. LSD isn't quite as well-researched as psilocybin as a psychiatric drug, but the data we have suggests that it isn't meaningfully different in terms of risks or benefits.

Psychedelics are likely to be a good option for some patients, it's good to have another tool in the armamentarium, but the idea that they're a revolution in psychiatry is simply no longer credible.

https://pubmed.ncbi.nlm.nih.gov/39627679/

Disclosure: I have participated in a clinical trial of psilocybin for treatment-resistant depression and did not see any meaningful benefit.

Farage announced his intention to stand in this by-election (which he is entitled to do), arguing that only his constituents had the right to decide whether he was fit to be a Member of Parliament. He argues that the Standards Committee is fundamentally illegitimate because he would be judged by his political rivals; in any case, the greatest sanction the committee could impose would be his expulsion from parliament, which would trigger a by-election that he would be entitled to stand in. The other major parties have all decided not to stand candidates against Farage in the Clacton by-election, creating this slightly farcical contest between the incumbent and a joke candidate.

The various curves and bevels on the Stratocaster aren't arbitrary aesthetic features, they're affordances to fit the human body. Change them too much and you get a guitar that won't balance on your knee or that pokes you in the ribs or that limits your access to the high frets.

Ola Strandberg set out to design the most ergonomic guitar possible. His design is both radical and basically derivative of the Strat, because Leo Fender happened to find something close to the perfect solution in 1954.

https://strandbergguitars.com/en-GB/product/boden-essential-...

https://www.ons.gov.uk/peoplepopulationandcommunity/personal...

Not any more. A new generation of locks have an abrasive-filled plastic layer that aggressively wears down angle grinder discs. They aren't completely immune to angle grinders, but the better locks will take 20 minutes and multiple cutting discs to defeat.

https://www.cyclingweekly.com/group-tests/wrecked-and-rated-...

https://www.youtube.com/watch?v=x5tuFesVtAA

It's notable that adhesives are something that Chinese manufacturers still really struggle with. Companies like Henkel and 3M have a deep reservoir of trade secrets.

Comments URL: https://news.ycombinator.com/item?id=47022547

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https://data.energizer.com/pdfs/l91.pdf

https://www.medtronicdiabetes.com/sites/default/files/librar...

I can't think of any good applications for conventional NiMH cells any more - they're dominated by LSD NiMH cells in low-discharge applications, by lithium primary cells in ultra-low-discharge applications and by the various lithium secondary chemistries in high-discharge applications.

The entire problem is that most people in high- and middle-income countries are in fact doing something blatantly wrong - they are consistently eating vastly more calories than they use. Some of those people are ignorant of what 2000 to 2500 calories actually looks like, some are deluded, but a very large proportion know damned well that they're eating far too much and do it anyway.

The obesogenic environment that we now live in is partly due to the influence of the processed foods industry, but in large part it's simply a product of abundance. Before the late 20th century, it was simply inconceivable that poor people could afford to become morbidly obese. Agricultural productivity has improved beyond all recognition and the world is flooded with incredibly cheap food of all kinds.

We've spent the last few decades trying to push back against that with all manner of initiatives intended to endgender behavioural change, with very little success. It doesn't really matter what guidance we give people when they have shown a consistent inability or unwillingness to follow it.

If we're actually serious about the effects of diet on public health, I think there are only two credible options - extremely heavy-handed regulation, or the mass prescribing of GLP-1 receptor agonists. All of the other options are just permutations of "let's do more of the thing that hasn't worked".

The existence of such a large and conspicuous secret might seem bizarre to the post-cold-war mind, but it was fairly common in the West too. For example, the British Telecom Tower in central London stands at 189 metres tall and had a revolving restaurant that was open to the public, but was also a designated site under the Official Secrets Act.

Good governance is hard.