I spend less time in an editor now, but it's been satisfying being able to take features I've enjoyed from other editors and customise - and it's oriented a bit more towards exploring code than editing. Key-bindings are arranged such that bare letters are for motions, Shift- variants are then used to extend selections, Ctrl- bindings are for buffer mutations, and leader-prefixed bindings are application level (e.g., opening pickers).

https://github.com/joefreeman/aether

Beyond standard features (retries, caching, timeouts - enabled with attributes on the decorator), Coflux supports more novel features - like suspense (where a task can choose to go to sleep and get restarted when a result it depends on becomes available), memoisation (where steps within a run are aggressively cached so that you can re-run steps in a workflow without re-running upstream steps), and the ability to re-run a step in a different workspaces (with updated code, or in a different environment).

It turns out this works great for implementing agentic systems - you can provide references to tasks as tools to an LLM call and have the AI drive - tasks can be easily sandboxed. And Claude is very capable of using the CLI to interact with the orchestration server to submit workflows, investigate failed runs, make updates to workflows and re-run steps.

I'm trying to make sure it's easy to try out - there's a self-contained CLI that can be used to start the server (a single Docker container), run worker processes, and then interact with the server. The dev mode automatically restarts the workers as you make local changes. There's also a hosted UI for observing runs in real-time, where you can see the execution graph, access logs/metrics/assets/etc - it works without creating an account - the browser interacts with your orchestration server directly.

It solves a similar problem to Phoenix LiveView, but aimed at a different level of abstraction: rather than synchronising HTML and UI events, this just synchronises (JSON-serialisable) state.

Topics can be shared between connected users, and each client can subscribe to multiple topics. The library takes care of starting topic instances (GenServer processes) as needed, then shuts them down when they're no longer in use. A topic is defined with an initialisation function (which can be used to load the initial state and/or subscribe to updates from a database/etc), and can then respond to requests/notifications from clients, or arbitrary BEAM messages, to efficiently update (and synchronise) state.

The library can be used directly from Elixir, or there's a Cowboy adapter that can be used along with the JavaScript client or React hook.

I've put together a few very basic examples. Some use cases I think this works great for are, a) synchronising ephemeral state (e.g., cursor positions); b) as a layer over a database for synchronising real-time updates to persisted state. In particular, this works pretty well for event-sourcing-type scenarios - you can load events from the database, subscribe to updates, and (if needed) periodically take snapshots of the state.

Please let me know what you think.

https://github.com/joefreeman/topical

Comments URL: https://news.ycombinator.com/item?id=37692438

Points: 8

# Comments: 0

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced full-stack (/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges throughout the stack. We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

Ideal candidates would:

  - Have an interest in working in BioTech/HealthTech (experience not necessary)
  - Have a strong academic background
  - Be based in/around London
  - Be self-motivated, and have experience working in a high-output team
  - Mention these things when getting in touch (and not be CC-ing every e-mail address on this page!)

jfreeman+hn@genpax.co

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced full-stack (/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges throughout the stack. We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

Ideal candidates would:

  - Have an interest in working in BioTech/HealthTech (experience not necessary)
  - Have a strong academic background
  - Be based in/around London
  - Be self-motivated, and have experience working in a high-output team
  - Mention these things when getting in touch (and not be CC-ing every e-mail address on this page!)

jfreeman+hn@genpax.co

    type Item = {
        name: string;
        ...
        size?: string;

But then the example response:

    "size": 16

Is it? It's not even returning the type being asked for?

I'm guessing this is more of a typo in the example, because otherwise this seems cool.

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced frontend (or full-stack/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges here (and throughout the stack). We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

£55-100k + equity, based on experience.

jfreeman+hn@genpax.co

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced frontend (or full-stack/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges here (and throughout the stack). We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

£55-100k + equity, based on experience.

jfreeman+hn@genpax.co

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced frontend (or full-stack/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges here (and throughout the stack). We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

£55-100k + equity, based on experience.

jfreeman+hn@genpax.co

We're building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens.

Our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and appropriate responses to more dangerous or more antibiotic resistant strains. We have developed a unique solution to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

I'm looking for an experienced frontend (or full-stack/'product') engineer to join our small engineering team - initially to focus on building out a novel interactive tree-based UI. There are some interesting challenges here (and throughout the stack). We're using Python, GraphQL, React/TypeScript, Postgres and AWS, but open minded to adopting technologies that make sense.

£55-100k + equity, based on experience.

jfreeman+hn@genpax.co

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and the bioinformatics algorithms we use; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. At the moment we're using Python, GraphQL, React/TypeScript, Postgres and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and the bioinformatics algorithms we use; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. At the moment we're using Python, GraphQL, React/TypeScript, Postgres and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

Our company values software quality and we're very product focussed. We're actively hiring in London: https://news.ycombinator.com/item?id=33423547

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and the bioinformatics algorithms we use; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. At the moment we're using Python, GraphQL, React/TypeScript, Postgres and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

We already have a world-class scientific team of bioinformaticians, and we're building out an engineering team to match. There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and the bioinformatics algorithms we use; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. We're still in early stages - so far we’re using Python, GraphQL, React/TypeScript, Postgres and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can help hospitals take early and effective action against outbreaks of MRSA and other pathogens. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

We already have a world-class scientific team of bioinformaticians, and we're building out an engineering team to match. There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and the bioinformatics algorithms we use; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. We're still in early stages - so far we’re using Python, GraphQL, React/TypeScript, Postgres and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

Genpax is building a game-changing bacterial analysis platform. Using bioinformatics, we can, for example, help hospitals take early and effective action against outbreaks of MRSA. This is an opportunity to have a real-world impact on thousands of lives each year.

At Genpax our goal is to radically increase the utility, scalability, and speed with which whole genome sequencing (WGS) data delivers infection control solutions for human and animal healthcare worldwide. This will enable proactive control at early stages of outbreaks, and to respond appropriately to more dangerous or more antibiotic resistant strains. We have developed unique solutions to address the challenges and our goal is to provide access to these solutions in a fully scalable system.

We already have a world-class scientific team of bioinformaticians, and we're building out an engineering team to match. There are really interesting engineering problems to be solved: scaling and optimising our analysis pipeline and bioinformatics algorithms; building out our interactive graph-based user-facing product; developing cryptographic techniques for analysis of anonymised data. We’re still in early stages - so far we’re using Python, GraphQL, React/TypeScript and AWS.

£45-95k + equity, based on experience.

jfreeman+hn@genpax.co

[1] https://news.ycombinator.com/item?id=23702401