Hacker News: jonlucc

New comment by jonlucc in "GameStop makes $55.5B takeover offer for eBay"

jonlucc — Tue, 05 May 2026 01:00:47 +0000

This is part of the value prop of TCGPlayer, which was bought by eBay. They're specifically a marketplace for trading cards. Like Amazon, sellers can keep their product and sell it through the site, they can ship their inventory to TCGPlayer to manage logistics, and TCGPlayer sells cards on their own.

New comment by jonlucc in "Why has there been so little progress on Alzheimer's disease?"

jonlucc — Sun, 26 Apr 2026 14:30:50 +0000

This does happen. SAEs are reported in real time, and they do halt trials sometimes. Also, there is often a condition of approval that requires ongoing data collection for adverse events post-approval.

New comment by jonlucc in "Google plans to invest up to $40B in Anthropic"

jonlucc — Fri, 24 Apr 2026 22:20:23 +0000

I can say in one role in my job, I'm getting a lot of use and I know my colleagues are at least trying a lot of things. One use is a first-pass review of animal care and use protocols. The Claude project was given all of the relevant policies and guidelines as well as a fairly long prompt that explains the things we look for in protocol review. It's checking some things that the software we use makes very tedious to check and raising inconsistencies between sections. Some places have a full time "protocol reader" who does this kind of first check, but we've never had that, so it's helpful.

Another project I'm seeing in the same realm is taking an approved protocol and some study results and checking that the records of what was done match what they said they could do in the approved protocol. It can also make sure that surgical records have all the things they should have. This can help meet one of the requirements from the national accreditation organization to do "post approval monitoring".

Another way I've used it is to have it collate and compare a particular kind of policy across many institutions who transparently put their policies online. Seeing the commonality between the policies and where some excel helped me rewrite our policy.

This is work that just wasn't happening before or, more accurately, it was being spread over lots of people, and any improvement in efficiency or consistency is hard to measure.

New comment by jonlucc in "Claude Design"

jonlucc — Fri, 17 Apr 2026 17:22:50 +0000

I'm not the one saying my job is uniquely human. Last week, I watched a video of a vendor's new facility that entirely automates antibody production and screening lab. The machines run literally every step from picking antibodies, sequencing, scaling up, and in vitro screening without a human interfering or donning a labcoat. A machine that is essentially a nicer roomba fetches the flask and drives it to where the shakers are and puts it on an empty shaker spot. I have no doubt the lab tasks I do can be automated. Fortunately for me, a large portion of my job at the moment is in handling animals, and there are much higher barriers there, but again, I don't think that part of my job makes me irreplaceable.

New comment by jonlucc in "Claude Design"

jonlucc — Fri, 17 Apr 2026 15:53:35 +0000

Claude, add a bit of whimsy to this design.

New comment by jonlucc in "Claude Design"

jonlucc — Fri, 17 Apr 2026 15:51:52 +0000

Frequently, two movies with very similar concepts drop the same year. Is that because they're spying, or because the companies make decisions in similar ways based on similar input information?

New comment by jonlucc in "Claude Design"

jonlucc — Fri, 17 Apr 2026 15:45:55 +0000

Transparently, I'm not a designer, I'm a biologist. That said, the things I want designed by Claude don't need great design. I need a slide format that is consistent from one study to the next so the reader can follow. I need a tool that tracks the number of mice in each lab and flags if someone is using more resources than we expect. I need a personal site that is easy to work with that tracks my pet geckos' feed and environment.

If I have a product out of my lab that makes it to human trials, there will be a full team of marketers and designers tasked to the brand image.

New comment by jonlucc in "Billy bookshelves as a retro motherboard "rack""

jonlucc — Thu, 05 Mar 2026 15:20:15 +0000

Are Billy deep enough for vinyl? It looks to me like they're only 11.75" deep, not 13.

New comment by jonlucc in "Judge orders government to begin refunding more than $130B in tariffs"

jonlucc — Thu, 05 Mar 2026 15:08:14 +0000

In practice, the entities who gave money directly to the US government are the ones who paid the tariff. Those entities should be pressured to refund the consumers, but in practice, that's unlikely.

I (unknowingly) ordered something on Etsy from another country. UPS delivered the items, then sent me a letter requiring I pay the tariff and an extra tariff handling fee. UPS paid the government, so UPS should get their money back from the government, then refund me. I'm not holding my breath.

New comment by jonlucc in "Heathrow scraps liquid container limit"

jonlucc — Tue, 27 Jan 2026 14:10:30 +0000

I guess the comms people got their hands on it before they deployed the original mnemonic: 3.4-1-1

New comment by jonlucc in "California invests in battery energy storage, leaving rolling blackouts behind"

jonlucc — Sat, 25 Oct 2025 22:55:03 +0000

This is an inherent problem with storing power. There's a massive battery in Missouri known as the Taum Sauk hydroelectric dam. During the night, they pump water up the hill into the upper reservoir, and in the day, they let the water run downhill through turbines to generate electricity. In 2005, the wall of the upper reservoir failed.

New comment by jonlucc in "Show HN: I'm an airline pilot – I built interactive graphs/globes of my flights"

jonlucc — Fri, 27 Jun 2025 13:14:00 +0000

This is great data visualization of interesting data! I'm curious about the last graph; there seems to be something making some of the longest flights take more time/nm. Is that real or an artifact, and is there an explanation for the tail?

New comment by jonlucc in "RFK Jr.: HHS moves to restore public trust in vaccines"

jonlucc — Tue, 10 Jun 2025 06:41:58 +0000

This is true, but leading up to the vaccine, he embraced every stupid conspiracy, related to COVID and before. Remember the bleach and sunshine press conference? A better leader who actually tried to understand the science at a basic level when they have their choice of incredible experts would have been better at communicating to the public from the beginning. He let the horse out of the barn, and that's famously hard to undo.

New comment by jonlucc in "Legged Locomotion Meets Skateboarding"

jonlucc — Fri, 21 Mar 2025 17:17:11 +0000

Based on the title alone, I thought this might be a skateboard that moved on millipede style legs, rather than wheels.

New comment by jonlucc in "Bispecific antibodies potently neutralize SARS-CoV-2 variants of concern"

jonlucc — Mon, 10 Mar 2025 04:35:47 +0000

Also of note because of recent political choices, these are humanized mice, meaning they're transgenic. They have a human ACE2 gene instead of the mouse ACE2 gene, which makes the human version of the enzyme that the COVID virus uses to enter cells. This isn't my exact field, so I'm not positive, but I remember hearing that all of the COVID mouse models require transgenic mice.

New comment by jonlucc in "Grok3 Launch [video]"

jonlucc — Tue, 18 Feb 2025 14:36:06 +0000

If you're paying $200/month for something I can do with open source software and $10/month of compute, why wouldn't I offer you the service for $100/month? And then someone offer it for $50?

Not everyone has to know about, understand, or use open source solutions for it to open the field.

New comment by jonlucc in "Show HN: ESP32 RC Cars"

jonlucc — Mon, 03 Feb 2025 13:43:48 +0000

I think you're looking for CircuitPython, which is available on a variety of small boards [0]. Based on my, admittedly, very limited experience, I would strongly consider the Feather line of products from Adafruit [1]; they're compatible with each other, most have CircuitPython support, and they mostly have STEMMA QT ports for simple connections to I2C-based peripherals.

[0] https://circuitpython.org/downloads [1] https://www.adafruit.com/category/943

New comment by jonlucc in "In the belly of the MrBeast"

jonlucc — Tue, 14 Jan 2025 19:10:40 +0000

I know it's been a while, but I think Jenny Nicholson grew her audience with shorter content. I recall "script meeting" videos about a lot of movies as they came out, and those were shorter and more frequent. Now that she has a dedicated audience, she doesn't rely as much on the algorithm to surface her.

New comment by jonlucc in "Netflix buffering issues: Boxing fans complain about Jake Paul vs. Mike Tyson"

jonlucc — Sat, 16 Nov 2024 18:58:08 +0000

> Even Twitter was having problems

Is that a surprise? They're not who I would think of first as a gold standard for high viewership live streams.

New comment by jonlucc in "FDA clears first over-the-counter continuous glucose monitor"

jonlucc — Wed, 06 Mar 2024 21:30:35 +0000

I'm not sure how much I can say; I don't work for a CGM company, but my company is very interested in diabetes. There are non-device reasons you can't use a CGM indefinitely. The site becomes less reliable over time, and it varies from peron to person. I'm not sure if the Stelo has addressed any of those, or if the G7 was overly cautious, or something else, but there are biological things happening at the site that affect the time too.