Hacker News: lawrenceyan

Test Like You Fly

lawrenceyan — Fri, 22 May 2026 17:20:14 +0000

Article URL: https://www.spacex.com/content/starship/test-like-you-fly

Comments URL: https://news.ycombinator.com/item?id=48238732

Points: 1

# Comments: 0

Gut Instinct: Connecting with our intuition

lawrenceyan — Tue, 12 May 2026 04:13:51 +0000

Article URL: https://www.cheltenhamzen.co.uk/writings/gut-instinct

Comments URL: https://news.ycombinator.com/item?id=48104118

Points: 1

# Comments: 0

New comment by lawrenceyan in "Why has there been so little progress on Alzheimer's disease?"

lawrenceyan — Sun, 26 Apr 2026 18:00:03 +0000

I'd argue the reason we’ve spun our wheels on Alzheimer's for decades isn't just about a flawed amyloid model. It’s a symptom of a much larger, dying paradigm in biotech.

For decades, the industry standard was to hunt for targeted small molecules to solve singular biological issues. And to be fair, I don't think this was because of a lack of vision as it was simply the strict limit of our technological capabilities at the time. But attempting to treat a cascading, systemic disease like Alzheimer's with a single targeted molecule is like hoping replacing one pipe will solve the problem when the issue is that the entire plumbing system is corroding.

This fundamental mismatch is exactly why clinical progress has stalled, and I believe the future of treating Alzheimer's will instead closely mirror how our approach to oncology has evolved.

We spent years searching for a universal molecule to cure cancer before we accepted reality. We now know that effective treatment often requires sequencing a tumor's mutanome to develop a highly personalized intervention for the individual. As neurodegenerative systems fail with age, we face that exact same biological complexity. A traditional small molecule is not going to rescue a globally failing network.

My personal take is that we won't see a true breakthrough in Alzheimer's until capital fully rotates out of these legacy, single-target pipelines and into programmable biological systems.

Lazard's Levelized Cost of Energy (2025) [pdf]

lawrenceyan — Fri, 24 Apr 2026 19:42:17 +0000

Article URL: https://www.lazard.com/media/5tlbhyla/lazards-lcoeplus-june-2025-_vf.pdf

Comments URL: https://news.ycombinator.com/item?id=47894892

Points: 3

# Comments: 0

Artemis, Greatness, and Risk

lawrenceyan — Fri, 10 Apr 2026 18:20:23 +0000

Article URL: https://1517.substack.com/p/1-in-30-artemis-greatness-and-risk

Comments URL: https://news.ycombinator.com/item?id=47721795

Points: 3

# Comments: 0

New comment by lawrenceyan in "Marc Andreessen is wrong about introspection"

lawrenceyan — Fri, 03 Apr 2026 18:40:10 +0000

What Andreessen is hinting at, albeit still largely surface level, is 无心 or no mind.

Popular in martial arts and Buddhist philosophy, I think practically what you should take away is that body and mind are fundamentally intertwined.

Introspection is a practice of the mind, specifically cognition centered around portions of the brain like the prefrontal cortex. There’s a lot more to who you are and areas you can hone / cultivate.

The HN crowd is probably overweighted on cognition, and could do with spending more time in other areas: https://www.cheltenhamzen.co.uk/writings/gut-instinct

Blessed: A high-level terminal interface library for Node.js

lawrenceyan — Fri, 27 Mar 2026 15:01:54 +0000

Article URL: https://github.com/chjj/blessed

Comments URL: https://news.ycombinator.com/item?id=47543471

Points: 3

# Comments: 0

Ju Ci: The Art of Repairing Porcelain

lawrenceyan — Sat, 21 Mar 2026 15:07:29 +0000

Article URL: https://thesublimeblog.org/2025/03/13/ju-ci-the-ancient-art-of-repairing-porcelain/

Comments URL: https://news.ycombinator.com/item?id=47467719

Points: 118

# Comments: 13

On the road to C4 rice: Advances and perspectives

lawrenceyan — Sun, 08 Mar 2026 00:53:12 +0000

Article URL: https://onlinelibrary.wiley.com/doi/full/10.1111/tpj.14562

Comments URL: https://news.ycombinator.com/item?id=47293175

Points: 5

# Comments: 0

The Antifragile Organization: Designing Systems That Evolve Through Chaos

lawrenceyan — Sat, 07 Mar 2026 18:03:26 +0000

Article URL: https://medium.com/@adocarreno/the-antifragile-organization-designing-systems-that-evolve-through-chaos-d4acf9df8edc

Comments URL: https://news.ycombinator.com/item?id=47289946

Points: 7

# Comments: 0

Algebraic methods for interactive proof systems (1992)

lawrenceyan — Mon, 16 Feb 2026 18:39:07 +0000

Article URL: https://dl.acm.org/doi/10.1145/146585.146605

Comments URL: https://news.ycombinator.com/item?id=47038513

Points: 2

# Comments: 0

New comment by lawrenceyan in "Don't rent the cloud, own instead"

lawrenceyan — Thu, 05 Feb 2026 17:04:39 +0000

Hetzner bare metal ran much of crypto for many years before they cracked down on it.

New comment by lawrenceyan in "Building a 24-bit arcade CRT display adapter from scratch"

lawrenceyan — Thu, 05 Feb 2026 00:12:34 +0000

There's something deeply poetic about using modern engineering knowledge to breathe new life into the warm, fuzzy glow of an analog CRT.

New comment by lawrenceyan in "NASA’s High Performance Spaceflight Computer (2024)"

lawrenceyan — Thu, 05 Feb 2026 00:09:10 +0000

This is really cool, thanks for surfacing.

New comment by lawrenceyan in "RS-SDK: Drive RuneScape with Claude Code"

lawrenceyan — Thu, 05 Feb 2026 00:07:40 +0000

Going to be so awesome when we have native crypto rails live in game for mmorpgs.

New comment by lawrenceyan in "As Rocks May Think"

lawrenceyan — Thu, 05 Feb 2026 00:03:32 +0000

Biggest update I see is that he thinks AI 2027 is actually going to happen.

New comment by lawrenceyan in "Claude is a space to think"

lawrenceyan — Thu, 05 Feb 2026 00:00:41 +0000

Build out distribution first and generate network effects.

New comment by lawrenceyan in "Technocracy 2.0"

lawrenceyan — Wed, 04 Feb 2026 23:58:50 +0000

This piece totally misreads the temperament of actual builders imo. The author confuses a malicious will to power with a genuine, if sometimes naive, optimism that code/crypto can solve human coordination problems.

New comment by lawrenceyan in "A sane but bull case on Clawdbot / OpenClaw"

lawrenceyan — Wed, 04 Feb 2026 23:50:01 +0000

Found this short story on Openclaw to be relevant:

https://x.com/gf_256/status/2018844976486945112

The Inevitable Future of Stablecoins

lawrenceyan — Wed, 04 Feb 2026 23:15:27 +0000

Article URL: https://layerzero.network/blog/the-inevitable-future-of-stablecoins

Comments URL: https://news.ycombinator.com/item?id=46893295

Points: 3

# Comments: 0