Hacker News: logannyeMD

New comment by logannyeMD in "I'm Eric Ries, author of "The Lean Startup" and new book "Incorruptible" – AMA"

logannyeMD — Wed, 10 Jun 2026 18:32:24 +0000

No question, really - just wanted to say thanks for evangelizing this topic. I'm originally a medical doctor who converted to the ways of computer science, now a founder in the bio space. One thing I've consistently wrestled with is how to structurally defend our company's ability to "first, do no harm." I think the misguided incentives you raise warning about are also the primary reason for the defects we see in our (American) healthcare system today, particularly with the grievances toward big pharma and the insurance industry. So I was pumped watching your interview with Garry a few weeks back, currently working on applying it to our own little lemonade stand.

New comment by logannyeMD in "Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop"

logannyeMD — Tue, 26 May 2026 21:48:41 +0000

Hey guys, this is my github repo. Glad it's received some interest - I figured HN might be the culprit when it suddenly jumped ~100 stars despite not working on the code base since last year. I prototyped this out of personal curiosity last year and moved on abruptly so there's a lot of gaps I still need to close and knobs that need to be optimized. But if people genuinely find "deterministic genomics workloads on edge devices" proposal useful, I'll begin refining the code tonight and try to make it as useful as possible. If you have any particular bioinformatics tasks or use cases that you want to be feasible on edge devices, lmk and I'll work on integrating new capabilities. Always happy to be helpful

New comment by logannyeMD in "Colon cancer now leading cause of cancer deaths under 50 in US"

logannyeMD — Thu, 12 Mar 2026 17:18:15 +0000

I'll echo this by saying that, as someone who has their MD, there is much we simply do not know. We're always updating our priors and have much to base our decisions off of, but we simply do not understand many things. Medicine is out here winging it with the best of intentions, but there are no "experts" in the grand scheme of things.

AlphaGenome

logannyeMD — Thu, 29 Jan 2026 00:39:34 +0000

Article URL: https://github.com/google-deepmind/alphagenome_research

Comments URL: https://news.ycombinator.com/item?id=46804044

Points: 2

# Comments: 0

Jensen Huang on the Joe Rogan Experience [video]

logannyeMD — Wed, 03 Dec 2025 18:23:45 +0000

Article URL: https://www.youtube.com/watch?v=3hptKYix4X8

Comments URL: https://news.ycombinator.com/item?id=46138017

Points: 16

# Comments: 4

New comment by logannyeMD in "There is No Quintic Formula [video]"

logannyeMD — Sun, 30 Nov 2025 20:47:12 +0000

2swap makes some fantastic videos, I'd recommend giving them a follow on YT if you enjoy math visualizations. They also seem to spend quite a bit of time on the audio for each upload

Pope Leo XIV: "AI and Medicine: The Challenge of Human Dignity"

logannyeMD — Fri, 14 Nov 2025 18:15:08 +0000

Article URL: https://www.vatican.va/content/leo-xiv/en/messages/pont-messages/2025/documents/20251107-messaggio-ai-medicine.html

Comments URL: https://news.ycombinator.com/item?id=45929840

Points: 7

# Comments: 0

Show HN: I made an open-source Rust program for memory-efficient genomics

logannyeMD — Thu, 13 Nov 2025 02:56:50 +0000

My cofounder and I run a startup in oncology, where we handle cancer genomics data. It occurred to me that, thanks to a recent complexity theory result, there's a clever way to run bioinformatics algorithms using far less RAM. I built this Rust engine for running whole-genome workloads in under 100MB of RAM. Runtime is a little longer as a result - O(TlogT) instead of O(T). But it should enable whole-genome analytics on consumer-grade hardware.

Comments URL: https://news.ycombinator.com/item?id=45909972

Points: 17

# Comments: 0

Show HN: An ETL engine with hard memory guarantees

logannyeMD — Tue, 04 Nov 2025 23:25:17 +0000

This is an external-memory ETL engine that enforces hard memory bounds (as opposed to systems that can only try to stay within limits). It's the result of playing around with a recent idea from complexity theory, tinkering to find practical applications of where efficient time-space simulation could be useful.

It enforces a strict memory cap via RAII tracking and scheduling, so you can process arbitrarily large datasets with a fixed, small memory footprint. Operators automatically spill to disk when needed. Might be helpful for serverless and edge environments where you need predictable resource usage.

Comments URL: https://news.ycombinator.com/item?id=45817075

Points: 2

# Comments: 0

Clay Mathematics Institute: Status of P vs. NP [video]

logannyeMD — Fri, 31 Oct 2025 13:57:59 +0000

Article URL: https://www.youtube.com/watch?v=HX9i9PL8os0

Comments URL: https://news.ycombinator.com/item?id=45772047

Points: 4

# Comments: 0

Nvidia Passes $5T Mark

logannyeMD — Wed, 29 Oct 2025 23:09:55 +0000

Article URL: https://www.cnbc.com/2025/10/29/nvidia-hits-5t-market-cap-without-china-sales-jim-cramer-says-that-could-change.html

Comments URL: https://news.ycombinator.com/item?id=45754312

Points: 3

# Comments: 0

New comment by logannyeMD in "I built a Texas Hold 'Em practice app after sucking at it during SF Tech Week"

logannyeMD — Mon, 20 Oct 2025 17:13:06 +0000

I recently went to a poker night during SF tech week and realized I'm not good at Texas Hold 'em. I wanted a way to improve that doesn't require me losing $100-200 every week, so I built this to get better between weekly poker nights. UI/UX is still very early, so any feedback that helps me make it more useful/delightful are appreciated. If you're in SF, hope to see you at one of the (many) weekly poker nights around the bay!

I built a Texas Hold 'Em practice app after sucking at it during SF Tech Week

logannyeMD — Mon, 20 Oct 2025 17:13:06 +0000

Article URL: https://holdem-coach.com/

Comments URL: https://news.ycombinator.com/item?id=45646399

Points: 1

# Comments: 1

New comment by logannyeMD in "Ask HN: What are you working on? (October 2025)"

logannyeMD — Mon, 13 Oct 2025 23:13:25 +0000

good idea, will add some this weekend

New comment by logannyeMD in "Ask HN: What are you working on? (October 2025)"

logannyeMD — Mon, 13 Oct 2025 01:54:06 +0000

Fwiw: the website is brand new and very much in the "hot garbage" phase of development. I'm not a front-end guy, so critique is welcome from all - especially any bugs in the UX. I'm still actively uncovering them

New comment by logannyeMD in "Ask HN: What are you working on? (October 2025)"

logannyeMD — Mon, 13 Oct 2025 00:06:13 +0000

Currently working on https://tinyZKP.com

It's an API that allows zero-knowledge proofs to be generated in a streaming fashion, meaning ZKPs that use way less RAM than normal.

The goal is to let people create ZKPs of any size on any device. ZKPs are very cool but have struggled to gain adoption due to the memory requirements. You usually need to pay for specialized hardware or massive server costs. Hoping to help fix the problem for devs

New comment by logannyeMD in "LoRA Without Regret"

logannyeMD — Fri, 03 Oct 2025 22:56:02 +0000

Missed opportunity to title this "Lo-RAgrets"

Quadratic memory reductions for Zero-knowledge Proofs

logannyeMD — Wed, 24 Sep 2025 02:12:58 +0000

Article URL: https://github.com/logannye/space-efficient-zero-knowledge-proofs

Comments URL: https://news.ycombinator.com/item?id=45355514

Points: 76

# Comments: 23

New comment by logannyeMD in "The Beginner's Textbook for Fully Homomorphic Encryption"

logannyeMD — Tue, 23 Sep 2025 01:14:08 +0000

FWIW: I created a github repo for compact zero-knowledge proofs that could be useful for privacy-preserving ML models of reasonable size (https://github.com/logannye/space-efficient-zero-knowledge-p...). Unfortunately, FHE's computational overhead is still prohibitive for running ML workloads except on very small models. Hoping to help make ZKML a little more practical.

Generating Zero-Knowledge Proofs in Sublinear Space

logannyeMD — Thu, 10 Jul 2025 20:49:09 +0000

Article URL: https://www.researchgate.net/publication/393569456_Zero-Knowledge_Proofs_in_Sublinear_Space

Comments URL: https://news.ycombinator.com/item?id=44525434

Points: 1

# Comments: 0