<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: marstall</title><link>https://news.ycombinator.com/user?id=marstall</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Wed, 09 Sep 2026 14:37:37 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=marstall" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by marstall in "AI in drug discovery – what it is, where we stand and the path forward"]]></title><description><![CDATA[
<p>how do you define the specialists? a prompt? what do you mean by using protocols as guardrails? Also, can you give me a TLDR on how these voice interfaces work? What kinds of problems are you solving, and how, in an ELI5 way. I might be a lot dumber than you give me credit for!</p>
]]></description><pubDate>Mon, 17 Aug 2026 15:04:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=49332225</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=49332225</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49332225</guid></item><item><title><![CDATA[New comment by marstall in "AI in drug discovery – what it is, where we stand and the path forward"]]></title><description><![CDATA[
<p>cool. i like what you've done here with a virtual panel that can answer questions ... i have similar ideas for kabuki syndrome (currently: <a href="https://www.thekabukipapers.org" rel="nofollow">https://www.thekabukipapers.org</a>). talk? marstall at gmail.</p>
]]></description><pubDate>Sun, 16 Aug 2026 11:12:45 +0000</pubDate><link>https://news.ycombinator.com/item?id=49318945</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=49318945</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49318945</guid></item><item><title><![CDATA[New comment by marstall in "DeepSeek Harness"]]></title><description><![CDATA[
<p>i've been using Cascade (a third party harness) since the 3 week period in 2023 when it was hot. I think it's called something else now. Devin? Things got confusing there for a second and I stopped paying attention.<p>Anyway very happy with it, I use it as a plugin to RubyMine and Webstorm.<p>One of the primary advantages is being able to choose your model - and it often has free deals for newer models that are running promotions. Whenever I switch to Claude Code it seems clunky. Would rather use Claude with Cascade.</p>
]]></description><pubDate>Thu, 13 Aug 2026 14:27:43 +0000</pubDate><link>https://news.ycombinator.com/item?id=49286503</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=49286503</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49286503</guid></item><item><title><![CDATA[New comment by marstall in "DeepSeek Harness"]]></title><description><![CDATA[
<p>is it just for coding? the docs don't mention code, just "agents"</p>
]]></description><pubDate>Thu, 13 Aug 2026 14:24:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=49286448</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=49286448</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=49286448</guid></item><item><title><![CDATA[New comment by marstall in "A Call to Action: Stop the FCC's KYC Regime"]]></title><description><![CDATA[
<p>"force phone providers to collect identity information from ordinary people before they can acquire or renew service with a phone carrier."<p>don't see the harm in this? isn't this already the case for 99.9% of phoneline havers already?</p>
]]></description><pubDate>Fri, 12 Jun 2026 15:21:25 +0000</pubDate><link>https://news.ycombinator.com/item?id=48505309</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48505309</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48505309</guid></item><item><title><![CDATA[New comment by marstall in "AI in the rare disease news desert"]]></title><description><![CDATA[
<p>I'm the creator of a newsletter using AI to make the science behind a rare disease, Kabuki Syndrome, more accessible.<p>In this blog post I walk through the steps I took to translate scientific papers into sparkling prose that maintains tight links between generated sentences and the passages they're based on, and touch on some of the broader issues related to what an editor is in a publication that is AI-generated, and why I think rare disease reporting is a uniquely appropriate and ethical use of AI!</p>
]]></description><pubDate>Tue, 12 May 2026 18:57:14 +0000</pubDate><link>https://news.ycombinator.com/item?id=48112733</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48112733</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48112733</guid></item><item><title><![CDATA[AI in the rare disease news desert]]></title><description><![CDATA[
<p>Article URL: <a href="https://www.thekabukipapers.org/articles/36">https://www.thekabukipapers.org/articles/36</a></p>
<p>Comments URL: <a href="https://news.ycombinator.com/item?id=48112732">https://news.ycombinator.com/item?id=48112732</a></p>
<p>Points: 3</p>
<p># Comments: 1</p>
]]></description><pubDate>Tue, 12 May 2026 18:57:14 +0000</pubDate><link>https://www.thekabukipapers.org/articles/36</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48112732</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48112732</guid></item><item><title><![CDATA[New comment by marstall in "$500M for Virtual Biology Initiative, Funded by Zuckerbergs"]]></title><description><![CDATA[
<p>Philip Ball helped me understand this in his book "How Life Works." He makes the point that you can't understand language by understanding letters. Walking up to someone and just saying "L" won't have any effect. And given just an understanding of the alphabet, you would never be able to use that on its own to understand a whole book, you have to move up. The whole has its own kind of existence. I think about how hard it is for one individual to influence a culture. You kind of have to speak and operate at the highest level to change things. I know that's super vague but those are just the terms I've been thinking about it in.</p>
]]></description><pubDate>Tue, 12 May 2026 18:39:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=48112448</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48112448</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48112448</guid></item><item><title><![CDATA[New comment by marstall in "I'm going back to writing code by hand"]]></title><description><![CDATA[
<p>yes it all comes back to iteration, the original "vibe coding". for me, programming has always been about making it up as i go along. like an artist starts with one stroke, i started when i was 10 years old typing '10 print "hello, world" 20 goto 10' and i've never really stopped programming that way 47 years later. For me programming is the same as refactoring, they both happen in a continuous Zone throughout the day. The idea of spending this big period at the beginning Defining the Architecture then letting AI fill in the blanks makes no sense because I only know what the architecture is, what the product is, as part of a process of typing all day for days and weeks and months, that never ends.</p>
]]></description><pubDate>Tue, 12 May 2026 15:42:08 +0000</pubDate><link>https://news.ycombinator.com/item?id=48109921</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48109921</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48109921</guid></item><item><title><![CDATA[New comment by marstall in "Digg tries again, this time as an AI news aggregator"]]></title><description><![CDATA[
<p>i've actually been wanting something like this.<p>issue seems to be there is way off the site? top story about thinking machines has no way to click through to original link AFAICS</p>
]]></description><pubDate>Tue, 12 May 2026 01:09:06 +0000</pubDate><link>https://news.ycombinator.com/item?id=48102936</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=48102936</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48102936</guid></item><item><title><![CDATA[New comment by marstall in "$500M for Virtual Biology Initiative, Funded by Zuckerbergs"]]></title><description><![CDATA[
<p>I've been reading "Elusive Cures" by Nicole Rust, about the failure of neuroscience to cure major ailments like schizophrenia and alzheimers, despite decades of work modeling neurons and other brain systems (costing far in excess of $500M).<p>Here are some thoughts that that book sparks ...<p>"the whole is <i>other</i> than the sum of its parts" - someone, based on Aristotle. The way Nicole Rust puts  is that the whole->part relationship is one way. In other words, you can determine the parts from the whole, but not the whole from the parts. A cell is a complex dynamic system with many overlapping and interacting feedback effects and diverse homeostatic drives. Its state emerges into its own entity that, once formed, bears only a tenuous relationship to its parts.<p>Understanding of our bodies and minds may be more tractable at more common levels, levels where the life system is <i>at</i> (whole), not where it <i>was</i> (parts) is where I think she's going: language, art, kinship, etc. But I'm not done yet.</p>
]]></description><pubDate>Fri, 01 May 2026 13:50:03 +0000</pubDate><link>https://news.ycombinator.com/item?id=47974803</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47974803</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47974803</guid></item><item><title><![CDATA[New comment by marstall in "OpenAI could be making a phone with AI agents replacing apps"]]></title><description><![CDATA[
<p>>  the OS layer will "see" everything and be able to ingest everything you do into a context<p>that makes sense, i could see it being useful. though it would be a feature easily replicated by Apple or Android if it got some traction.<p>Maybe this idea of apps being "replaced by agents" is less literal than I'm thinking.<p>Like with music, maybe it could be an agent that in general helps me be a cooler, more informed music listener by constantly thinking about new ways of accessing myriad sources of info about what's cool, or what I would think would be cool.</p>
]]></description><pubDate>Mon, 27 Apr 2026 15:58:55 +0000</pubDate><link>https://news.ycombinator.com/item?id=47923313</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47923313</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47923313</guid></item><item><title><![CDATA[New comment by marstall in "OpenAI could be making a phone with AI agents replacing apps"]]></title><description><![CDATA[
<p>here are some iphone apps i use often:<p>- Spotify<p>- Le Monde (french news)<p>- Maps<p>- Find My<p>- Amazon<p>Anyone have a take on how these (maybe not precisely) could be "replaced by an AI agent"?</p>
]]></description><pubDate>Mon, 27 Apr 2026 15:23:13 +0000</pubDate><link>https://news.ycombinator.com/item?id=47922861</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47922861</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47922861</guid></item><item><title><![CDATA[New comment by marstall in "The AI industry is discovering that the public hates it"]]></title><description><![CDATA[
<p>TNR - DNR</p>
]]></description><pubDate>Sat, 25 Apr 2026 23:03:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=47905469</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47905469</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47905469</guid></item><item><title><![CDATA[Fast Forward 10 years. What does computing look when AI is mature?]]></title><description><![CDATA[

<p>Comments URL: <a href="https://news.ycombinator.com/item?id=47798727">https://news.ycombinator.com/item?id=47798727</a></p>
<p>Points: 2</p>
<p># Comments: 0</p>
]]></description><pubDate>Thu, 16 Apr 2026 20:02:25 +0000</pubDate><link>https://news.ycombinator.com/item?id=47798727</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47798727</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47798727</guid></item><item><title><![CDATA[New comment by marstall in "90% of CEOs Say AI Changed Nothing. The Other 10% Have a PR Team"]]></title><description><![CDATA[
<p>it may be hard to measure, but it's definitely helping everyone who uses it to be more productive in certain aspects of their work. that's clear to me.<p>but it might be, say, 20% more productive in 20% of your workday, or 1000% more productive 2 days per month (the days when that perfect dream spec hits your desk that you can just paste into claude and get a slick working system back), which works out to just 4% more productive overall, or whatever, which is hard to measure with all the noise.<p>in the end companies will pay for these tools because their employees will be demanding them, same as they demand other things that make their workday more pleasant -  email, coffee, air conditioning, a conveniently located office, etc.<p>that said, I see the intelligence itself being rapidly commodified/free. the companies that extract rent in the sector will be the ones that effectively bundle and sell corporate-friendly features with the core intelligence - compliance, tracking, productivity, systems integration, authentication, etc. etc. etc. Which is a competency companies like Salesforce, Microsoft, Google already possess, so they are likely to win. Plus a weird Euro variant of course.</p>
]]></description><pubDate>Tue, 14 Apr 2026 14:56:27 +0000</pubDate><link>https://news.ycombinator.com/item?id=47766486</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47766486</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47766486</guid></item><item><title><![CDATA[New comment by marstall in "Am I German or Autistic?"]]></title><description><![CDATA[
<p>I got 20% autistic, 80% Irish?</p>
]]></description><pubDate>Thu, 09 Apr 2026 14:29:02 +0000</pubDate><link>https://news.ycombinator.com/item?id=47704237</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47704237</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47704237</guid></item><item><title><![CDATA[New comment by marstall in "Slop is not necessarily the future"]]></title><description><![CDATA[
<p>| iterate on their product faster.
i've run into a situation where it really slowed iteration down, because i wasn't able at some point to explain in english what I wanted it to do and had to go into the code, which, lo and behold, I didn't understand. Ended up scrapping everything that had been generated and starting over by hand!</p>
]]></description><pubDate>Wed, 01 Apr 2026 10:05:35 +0000</pubDate><link>https://news.ycombinator.com/item?id=47598897</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47598897</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47598897</guid></item><item><title><![CDATA[New comment by marstall in "What major works of literature were written after age of 85? 75? 65?"]]></title><description><![CDATA[
<p>and he wrote them when he was completely blind!</p>
]]></description><pubDate>Tue, 31 Mar 2026 15:44:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=47589096</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47589096</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47589096</guid></item><item><title><![CDATA[New comment by marstall in "An AI agent published a hit piece on me"]]></title><description><![CDATA[
<p>or democracy/civilization attack. DHS/Putin siccing this kind of thing on democratic voter rolls around Nov. elections could be the least of it.<p>i could see a long tail of impenetrable chaos as private correspondence gets hacked, ppl get divorced, fired, fight back, flood the zone with their own reputationslop so they have a grounds for denial, decide to take it ALL down to distract. recursive waves of tyranny/chaos. this isnt the singularity we were promised!</p>
]]></description><pubDate>Sun, 15 Feb 2026 00:59:44 +0000</pubDate><link>https://news.ycombinator.com/item?id=47020098</link><dc:creator>marstall</dc:creator><comments>https://news.ycombinator.com/item?id=47020098</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47020098</guid></item></channel></rss>