A wooden frame supported an elliptical-shaped structure, 20 feet high, 6 feet wide at the ends and 25 feet across the middle. It contained 6 short tons of uranium metal, 50 short tons of uranium oxide and 400 short tons of graphite, at an estimated cost of $2.7 million. According to Robert Crease, CP-1 and preceding piles were "the largest unbonded masonry structures since the pyramids.

On December 2, 1942, Fermi announced that the pile had gone critical at 15:25. Fermi switched the scale on the recorder to accommodate the rapidly increasing electric current from the boron trifluoride detector. He wanted to test the control circuits, but after 28 minutes, the alarm bells went off to notify everyone that the neutron flux had passed the preset safety level, and he ordered Zinn to release the zip. The reaction rapidly halted. The pile had run for about 4.5 minutes at about 0.5 watts. Wigner opened a bottle of Chianti, which they drank from paper cups.