Hacker News: mfld

Genome Foundation Models

mfld — Tue, 02 Jun 2026 12:57:04 +0000

Article URL: https://andrewcarroll.github.io/2026/05/26/genome-foundation-models.html

Comments URL: https://news.ycombinator.com/item?id=48369633

Points: 2

# Comments: 0

Are blue zones real? Answering that question is harder then ever

mfld — Mon, 01 Jun 2026 13:40:35 +0000

Article URL: https://www.statnews.com/2026/05/04/are-blue-zones-real-new-scrutiny-longevity-hot-spots/

Comments URL: https://news.ycombinator.com/item?id=48356754

Points: 53

# Comments: 58

New comment by mfld in "EU fines Temu €200M for allowing sale of illegal products"

mfld — Thu, 28 May 2026 18:17:24 +0000

Maybe for marketplace articles shipped from outside the EU. It's not legal, so Amazon will surely have a close look (for directly sold items), as well as any company shipping from within the EU.

New comment by mfld in "Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop"

mfld — Wed, 27 May 2026 08:21:26 +0000

I guess the author refers to the fact that many well-known tools have some randomness built-in. The most obvious one is differences due to the order of parallel processing. But these differences are often small and have no significant downstream effects. They are mostly inconvenient for regression testing.

New comment by mfld in "Childhood Computing"

mfld — Sun, 24 May 2026 18:38:28 +0000

Does anyone remember the art of optimising MSDOS startup to have enough free memory for games? And inspecting gorillas.bas? For me, this probably contributed to an interest to learn more and experiment. In fact, I'd like to encourage my son to a similar creative exploration, but don't how this is going to happen when pulled into the current generation of games and videos.

New comment by mfld in "UK Biobank health data keeps ending up on GitHub"

mfld — Fri, 24 Apr 2026 10:58:21 +0000

This is the right mindset. Securing huge piles of heterogeneous data while giving PhD students the freedom to "play" with it are quite conflicting goals.

New comment by mfld in "Vibe Genomics: Sequencing Your Whole Genome at Home"

mfld — Mon, 20 Apr 2026 09:49:33 +0000

From a bioinformatics perspective, the general approach is fine. Here is another post from today where someone landed on the similar technologies: https://news.ycombinator.com/item?id=47825381

New comment by mfld in "macOS Tahoe windows have different corner radiuses"

mfld — Tue, 10 Mar 2026 12:02:20 +0000

https://en.wikipedia.org/wiki/Broken_windows_theory

New comment by mfld in "Redox OS has adopted a Certificate of Origin policy and a strict no-LLM policy"

mfld — Tue, 10 Mar 2026 09:41:17 +0000

Maybe a future direction will be the submission of detailed research, specifications and change plans for feature requests. Something that can be assessed by a human and turned into working code by both slides.

New comment by mfld in "A Visual Guide to DNA Sequencing"

mfld — Wed, 04 Mar 2026 19:09:43 +0000

Yes, they are only mentioned in the last section. Other notable misses would be Ion Torrent and MGI. Still a nice article with a focus on the key technologies.

Payments Processor Stripe Expresses Interest in PayPal

mfld — Wed, 25 Feb 2026 12:48:08 +0000

Article URL: https://www.bloomberg.com/news/articles/2026-02-24/payments-processor-stripe-expresses-interest-in-paypal

Comments URL: https://news.ycombinator.com/item?id=47150826

Points: 2

# Comments: 0

New comment by mfld in "I built Timeframe, our family e-paper dashboard"

mfld — Mon, 23 Feb 2026 09:51:07 +0000

Agree. I used a color e-ink to display my son's school timetable (previously discussed at https://news.ycombinator.com/item?id=42408546), and it has been running reliably for 18 months, with charging needed every 4-5 months. I note that the author (cool project!) also earlier took the route of displaying websites as PNGs.

New comment by mfld in "I tried building my startup entirely on European infrastructure"

mfld — Fri, 20 Feb 2026 14:25:21 +0000

Using it for both transactional and marketing emails (but "only" for thousands of recipients) for some years. Could need some polish IMO, but the core offering is solid. Support is helpful, too.

New comment by mfld in "OpenCiv3: Open-source, cross-platform reimagining of Civilization III"

mfld — Sat, 07 Feb 2026 06:31:18 +0000

This looks great! Shout out to FreeCol, a reimagined Colonization, that has the same isometric look and is a lot of fun.

The New Collabora Office for Desktop

mfld — Thu, 05 Feb 2026 13:47:59 +0000

Article URL: https://www.collaboraonline.com/collabora-office/

Comments URL: https://news.ycombinator.com/item?id=46899591

Points: 195

# Comments: 125

New comment by mfld in "Prism"

mfld — Wed, 28 Jan 2026 11:42:58 +0000

I'd like to hypothesize a little bit about the strategy of OpenAI. Obviously, it is nice for academic users that there is a new option for collaborative LaTeX editing plus LLM integration for free. At the same time, I don't think there is much added revenue expected here, for example, from Pro features or additional LLM usage plans. My theory is that the value lies in the training data received from highly skilled academics in the form of accepted and declined suggestions.

New comment by mfld in "EU–INC – A new pan-European legal entity"

mfld — Wed, 21 Jan 2026 12:55:23 +0000

It's a good price because the yearly statements for an LLC/GmbH are costly. We pay about 200/mo for accounting - with some more invoices :) -, 100/mo for payrolls but also the yearly statement alone is more than 2k. You can save that by not having an LLC - I personally think the risk in many software businesses is quite low. And some risks must be accepted as an entrepreneur...

New comment by mfld in "EU–INC – A new pan-European legal entity"

mfld — Wed, 21 Jan 2026 12:22:12 +0000

Agreed. In case you do not have big investors, just register as an individual entrepreneur, get a bank account and get going! It can be turned into a LLC/GmbH later if business goes well.

Also taxes will be much easier. Just get one of the countless apps where you add invoices, and they generate tax reports for you. With an LLC or when employing other people, getting a tax consultant is advised. IMO, they are not expensive - how many hours of your time are you willing to spend on this topic instead of paying e.g. 200 EUR/mo?

New comment by mfld in "Radboud University selects Fairphone as standard smartphone for employees"

mfld — Mon, 19 Jan 2026 12:19:49 +0000

My wife has a Fairphone 4, released 2021. The earpiece broke. I ordered a replacement; it arrived within 3 days and was very easy to replace. So a good experience with that.

New comment by mfld in "East Germany balloon escape"

mfld — Sat, 17 Jan 2026 09:29:46 +0000

You can compare them with the original calculations that can be found at https://www.ballonflucht.de/en/ballonrechner.html !