Hacker News: mhrmsn

New comment by mhrmsn in "Claude Fable 5"

mhrmsn — Tue, 09 Jun 2026 18:51:46 +0000

Are there any details on the biology and chemistry work they did?

For example, the AAV capsid assembly looks interesting, but for one Opus 4.8 also did relatively well and there is no information what exactly they did, what protein language models they compared to and what the score even means...

New comment by mhrmsn in "Ask HN: What works for cutting AI token costs?"

mhrmsn — Tue, 09 Jun 2026 07:30:00 +0000

Haven't benchmarked it, but for agentic coding e.g. Claude Code I found this useful:

https://github.com/rtk-ai/rtk

How much of Thermo Fisher's antibody data has been manipulated?

mhrmsn — Mon, 08 Jun 2026 06:56:06 +0000

Article URL: https://reeserichardson.blog/2026/05/28/how-much-of-thermo-fishers-antibody-data-has-been-manipulated/

Comments URL: https://news.ycombinator.com/item?id=48442075

Points: 442

# Comments: 91

New comment by mhrmsn in "Ask HN: What Are You Working On? (April 2026)"

mhrmsn — Sun, 12 Apr 2026 22:21:20 +0000

I recently started using Paperless to manage all my documents and wanted to include archive serial numbers (ASNs) for all physical documents that I scan, so I built a small tool to create and print archive serial number label sheets with QR/Barcodes:

https://asnlabels.com

It's free, no sign up or ads - feedback welcome :)

New comment by mhrmsn in "Ask HN: What are you building that's not AI related?"

mhrmsn — Thu, 09 Apr 2026 12:42:07 +0000

I recently started with Paperless-ngx and wanted to also include archive serial numbers (ASNs) for all paper documents using small label stickers, so I built a small tool to create and print ASN label sheets. It's free, no sign up, no ads and just runs in the browser:

https://asnlabels.com

If you're also using Paperless-ngx with ASNs or use them for something else, feedback welcome :)

New comment by mhrmsn in "Ask HN: What's your favorite number, and why?"

mhrmsn — Mon, 30 Mar 2026 21:29:28 +0000

4, because it can be written as 2+2, 2*2, 2^2, and all the other following hyperoperations Hn(2,2)

New comment by mhrmsn in "How I use every Claude Code feature"

mhrmsn — Sun, 02 Nov 2025 20:25:23 +0000

Same experience, although I gave up already a while ago so not sure if CLAUDE.md is better followed in newer versions.

New comment by mhrmsn in "Wero Wallet"

mhrmsn — Fri, 25 Jul 2025 16:00:56 +0000

I wish there was a European alternative to PayPal et al., but Wero seems too be too little too late and too slow.

Not enough banks participating, no ability to connect multiple accounts, credit cards etc., no payments integration with vendors and finally no incentives to switch vs. the incumbents in the space - I guess you would need a serious marketing campaign with discounts, cashback etc. to get people to use it and reach a critical mass. But let's see - maybe I'm too pessimistic...

New comment by mhrmsn in "How Anthropic teams use Claude Code"

mhrmsn — Fri, 25 Jul 2025 02:21:28 +0000

It'd be more interesting if they shared actual examples of complete prompts, CLAUDE.md files, settings and MCP servers to achieve certain things.

The documentation is good, but is kept relatively general and I have a feeling that the quality of Claude Code's output really depends on the specific setup and prompts you use.

New comment by mhrmsn in "Anthropic researchers discover thinking longer sometimes makes models dumber"

mhrmsn — Wed, 23 Jul 2025 22:30:45 +0000

No more "ultrathink", got it :)

New comment by mhrmsn in "Nobody knows how to build with AI yet"

mhrmsn — Sun, 20 Jul 2025 06:24:07 +0000

I think you can already kind of do that with something like vibetunnel :)

https://vibetunnel.sh

New comment by mhrmsn in "AnyCrawl.dev – High-Performance Web Scraping Platform Built for the AI Era"

mhrmsn — Sun, 01 Jun 2025 16:00:21 +0000

Looks interesting! Does any request count towards credits, e.g. 4xx response codes, rate limit hits etc.?

New comment by mhrmsn in "Ancient Four-Legged Whale Remains Discovered in Peru"

mhrmsn — Sun, 27 Apr 2025 05:01:44 +0000

Title and link don't seem to match.

New comment by mhrmsn in "Show HN: I built a tool to manage deployments across your VPS through a web UI"

mhrmsn — Tue, 28 Jan 2025 11:26:43 +0000

That was very helpful, thanks! Might give it a shot later this week for a new API :)

New comment by mhrmsn in "Show HN: I built a tool to manage deployments across your VPS through a web UI"

mhrmsn — Tue, 28 Jan 2025 08:59:32 +0000

Congratulations on the launch! I've been using CapRover in the past and wanted to try out Coolify recently, could you elaborate what the advantages of k3s/Longhorn might be (no experience with them)?

Are deployments from Github Actions possible (I'd assume some interface/API is needed for that)?

Thanks!

New comment by mhrmsn in "OpenAI's Sora has been leaked"

mhrmsn — Tue, 26 Nov 2024 16:42:33 +0000

From the title I thought code or model weights had been leaked, but it's access to Sora through Huggingface by a group of early testers.

With their auth tokens being used to provide the API access, won't OpenAI find out really quick who is behind that?

New comment by mhrmsn in "Is It Pokémon or Big Data?"

mhrmsn — Tue, 22 Oct 2024 10:59:25 +0000

Thanks, this was pretty funny. I also didn't realize how many different Pokémon there are today, definitely more than in the first Pokémon game on that clunky grey Gameboy I had :)

New comment by mhrmsn in "Chemistry Nobel: Computational protein design and protein structure prediction"

mhrmsn — Wed, 09 Oct 2024 15:04:18 +0000

Crispr is widely used and there are even therapies approved based on it, you can actually buy TVs that use quantum dots and click chemistry has lots of applications (bioconjugation etc.), but I don't think we have seen that impact from AlphaFold yet.

There's a lot of pharma companies and drug design startups that are actively trying to apply these methods, but I think the jury is still out for the impact it will finally have.

New comment by mhrmsn in "Chemistry Nobel: Computational protein design and protein structure prediction"

mhrmsn — Wed, 09 Oct 2024 11:47:12 +0000

Great achievement, although I think it's interesting that this Nobel prize was awarded so early, with "the greatest benefit on mankind" still outstanding. Are there already any clinically approved drugs based on AI out there I might have missed?

In comparison, the one for lithium batteries was awarded in 2019, over 30 years after the original research, when probably more than half of the world's population already used them on a daily basis.

New comment by mhrmsn in "Kagi T-Shirts Soft Launch"

mhrmsn — Fri, 30 Aug 2024 15:51:18 +0000

I was a bit surprised when they initially announced this, there was also some discussion here around them making the shirts themselves, where people were quite skeptical:

https://news.ycombinator.com/item?id=40011314

But now I'm actually looking forward to my T-Shirt, Doggo Original Yellow it is!