Hacker News: moioci

New comment by moioci in "Cancer-related mortality among US pilots and flight attendants"

moioci — Fri, 21 Aug 2026 18:20:51 +0000

It's a research letter, not a full article. Accordingly, there's no abstract. They just show the first of 11 paragraphs as a teaser.

New comment by moioci in "mRNA cancer vaccine shows protection at 5-year follow-up, Moderna and Merck say"

moioci — Sun, 25 Jan 2026 04:17:52 +0000

from clinicaltrials.gov:

Eligibility Criteria

Key Inclusion Criteria:

Resectable cutaneous melanoma metastatic to a lymph node and at high risk of recurrence

Complete resection within 13 weeks prior to the first dose of pembrolizumab

Disease free at study entry (after surgery) with no loco-regional relapse or distant metastasis and no clinical evidence of brain metastases

Has an formalin fixed paraffin embedded (FFPE) tumor sample available suitable for sequencing

Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1

Normal organ and marrow function reported at screening

Key Exclusion Criteria:

Prior malignancy, unless no evidence of that disease for at least 5 years prior to study entry

Prior systemic anti-cancer treatment (except surgery and interferon for thick primary melanomas. Radiotherapy after lymph node dissection is permitted)

Live vaccine within 30 days prior to the first dose of pembrolizumab

Transfusion of blood or administration of colony stimulating factors within 2 weeks of the screening blood sample

Active autoimmune disease

Immunodeficiency, systemic steroid therapy, or any other immunosuppressive therapy within 7 days prior to the first dose of pembrolizumab

Solid organ or allogeneic bone marrow transplant

Pneumonitis or a history of (noninfectious) pneumonitis that required steroids

Prior interstitial lung disease

Clinically significant heart failure

Known history of human immunodeficiency virus (HIV)

Known active hepatitis B or C

Active infection requiring treatment

Ages Eligible for Study 18 Years and older (Adult, Older Adult )

Sexes Eligible for Study All

Accepts Healthy Volunteers No

New comment by moioci in "Google's healthcare AI made up a body part – what if doctors don't notice?"

moioci — Tue, 23 Dec 2025 19:49:29 +0000

Not meaning to derail the thread, but ... What typo blew up the space shuttle? Challenger was lost when managers in a rush to launch overrode the recommendations of Thiokol engineers. Columbia was lost when a piece of insulation struck the leading edge of the left orbiter wing at launch and the risk to the shuttle was not recognized by those in charge.

New comment by moioci in "FDA approves Novo Nordisk's Wegovy pill, the first and only oral GLP-1"

moioci — Tue, 23 Dec 2025 19:08:06 +0000

Headline is incorrect; Rybelsus, an oral semaglutide, was approved in 2019. Maybe oral Wegovy is the first oral GLP-1 approved for obesity rather than diabetes.

New comment by moioci in "When irate product support customers demand to speak to Bill Gates"

moioci — Tue, 23 Dec 2025 18:21:28 +0000

Flip side is the well-known story of when billg actually answered a customer service call: https://www.entrepreneur.com/leadership/that-time-bill-gates...

New comment by moioci in "VA staff flag dangerous errors in Oracle-built electronic health record"

moioci — Thu, 04 Dec 2025 02:13:54 +0000

It says the second dose was "injected."

New comment by moioci in "Grief gets an expiration date, just like us"

moioci — Sat, 20 Sep 2025 20:23:01 +0000

https://www.youtube.com/watch?v=s_i59j74g3s

New comment by moioci in "Madison Square Garden's surveillance banned this fan over his T-shirt design"

moioci — Sat, 29 Mar 2025 19:30:50 +0000

There must be many thousands of people named Frank Miller, Jr. So something in addition to the name had to be used.

New comment by moioci in "The Objects of Our Life (1983)"

moioci — Thu, 18 Jul 2024 21:48:23 +0000

IIRC, on his deathbed he was complaining about the design of the hospital's suction catheters.

New comment by moioci in "Show HN: Personal website inspired by Apple notes"

moioci — Wed, 10 Jul 2024 23:39:13 +0000

I see a flash of white text on a dark background, then "Application error: a client-side exception has occurred (see the browser console for more information)." in black on the same very dark background. Chrome on Win 10

New comment by moioci in "How the square root of 2 became a number"

moioci — Fri, 21 Jun 2024 22:09:16 +0000

My bad. I was thinking A, B, and C were integers.

New comment by moioci in "How the square root of 2 became a number"

moioci — Fri, 21 Jun 2024 15:45:29 +0000

That would seem to imply that for A =/= 0, C/A is irrational. This seems counterintuitive.

New comment by moioci in "How ECMO is redefining death"

moioci — Wed, 01 May 2024 02:05:08 +0000

As others have mentioned, it's important to note that this is not a trial of ECMO vs no ECMO, but of immediate ECMO vs usual care including ECMO if needed, and that 39% of the control arm wound up receiving ECMO, which could have the effect of reducing apparent treatment benefit. Also, the 28% reduction in the primary endpoint could well reach statistical significance if the trial numbers were larger. Finally, this was for patients with cardiogenic shock, most likely predominantly heart attack patients. They likely represent a smallish portion of the patients who might be considered for ECMO, so one can't generalize to all scenarios.

New comment by moioci in "Intense exercise increases dopamine transport in substantia nigra in Parkinson's"

moioci — Mon, 26 Feb 2024 00:07:19 +0000

This reminds me of a story from several years ago where, as part of a bike-a-thon to benefit Parkinson's research, a Parkinson's patient rode a tandem bike with a family member providing the pedal power. This "passive exercise" led to a several day remission of Parkinsonian symptoms. The current article would provide a plausible mechanism for this effect.

New comment by moioci in "Target Figured Out a Teen Girl Was Pregnant Before Her Father Did (2012)"

moioci — Fri, 09 Feb 2024 21:52:58 +0000

Story may be apocryphal:

https://medium.com/@colin.fraser/target-didnt-figure-out-a-t...

New comment by moioci in "Someone stole a Jasper radio station’s 200-foot tower, owner says"

moioci — Fri, 09 Feb 2024 20:21:40 +0000

Jasper has always had a unique brand of criminal:

https://www.latimes.com/archives/la-xpm-1999-jul-29-mn-60726...

New comment by moioci in "Terrible real estate agent photographs"

moioci — Fri, 30 Jun 2023 13:26:36 +0000

> me and my wife took LSD on a vacation

Did dropping acid enhance your vacation, or does LSD also stand for something else?

New comment by moioci in "Underage Enlistment in the United States and the Confederacy"

moioci — Tue, 20 Jun 2023 22:20:12 +0000

A minor point that may have some relevance here. When I was doing genealogical research on my great grandfather who served in the US Civil War, I read that at the time, your legal age was considered to be the age you would attain by the end of the calendar year, so everyone officially aged up on January 1. By this convention, many 17 year-olds who enlisted would have been legally 18 and did not actually lie about their age.

New comment by moioci in "Parachute use to prevent death, trauma when jumping from aircraft (2018) [pdf]"

moioci — Fri, 02 Jun 2023 12:15:21 +0000

Study was unblinded, though.

New comment by moioci in "When Truman Capote’s lies caught up with him"

moioci — Sun, 22 Jan 2023 03:42:21 +0000

> a middling tennis player...

If you're referring to the 2006 NYT piece on Roger Federer, I think you're not supporting the "quite mundane" characterization

https://www.nytimes.com/2006/08/20/sports/playmagazine/20fed...