The article itself raises the issue of "lack of clinical data", given that these substances are relativelly new. But the lack of data may originate from a certain stiffness, or lack of accessibility and high cost of clinical trials. An alternative source of information are these people who self-experiment, but unfortunatelly this information is mostly lost instead of being captured.

How could this proposal work in practice? clearly the data would be noisy, contain some false reporting, biased, subjective etc. But statistical processing of a large number of reports (coming from hudreds of thousands or millions of self-reporting subjects) may still extract relevant scientific information; that we're dropping on the floor right now.

An example: I'm experimenting with a radical diet. I keep observations for myself, but they're not shared with anybody and don't contribute to science.

What the altervative would be: I would enroll on a web page, where I would describe the experiment I plan to do before I start it. I would be get a code for a blood/urine work for the "before" state, with the agreement that the results, anonimized, are shared with the platform. Weekly I would report on the platform observations, such as: got sick in this particular way, wheight variations, sleep eval, or any other changes.

At the end, or periodically I would get new free blood/urine work with the results shared.

Research institutes and pharma would get access to the data, to aggregate and denoise as they can to extract the latent information.

I don't understand, who's holding that "foreign held debt"? foreign countries I suppose, so which countries do you have in mind?

For one, it's not China, which holds a large amount of US treasury bonds (so basically, China is a lender of USD). So the revaluation of USD would work great for China: one, the value of the China-held USD bonds increases, and second, the price of Chinese exports decreases in USD terms.

So help me understand, what's the plan with the revaluation of USD?

Soon to be "Numerals of America"

What population growth?

It's nice to wish for the optimizer to do the [almost] perfect job, but sometimes that never arrives. Consider for example the case of AMD GPU ISA (GCN) generated by LLVM: it's been so far from optimal for so long, that one can lose hope that'll ever happen; and wish for a simple solution that works in the meantime.

Imagine that the GPU would instead suck up all the power it needs through the PCIe connector, without all those pesky cables. (right now PCIe can provied 75W at 12V, i.e. 6.25A; that same current would provide 300W at 48V).

  a = f(z);
  b = g(z);
  v = x > y ? a : b;

Also learned the meaning of the conspicuous word pulchritudinous, which in the default Oxford languages dictionary Google uses [1] comes up with "Dan gazed admiringly at the pulchritudinous brunette" as usage example.

[1] https://www.google.com/search?q=pulchritudinous

For example this blog post, about how great MI300X is. Really, what do I care -- I'm not a billionaire.