Hacker News: mrtesthah

New comment by mrtesthah in "The iPhone's Last Stand?"

mrtesthah — Wed, 10 Jun 2026 00:50:56 +0000

That sounds like an untestable hypothesis, aka conspiracy theory.

New comment by mrtesthah in "New drug 'functionally cures' many hepatitis B virus infections"

mrtesthah — Mon, 08 Jun 2026 15:45:39 +0000

Technically they are circular episomes — not integrated into chromosomal DNA like HIV.

And we do know that it’s possible to reduce the pool of reactivation-competent HSV genomes by the presence of IFNα during primary infection:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12764766/

This causes PML-NB formation → more viral genomes with H3K9me3 + ATRX → resists eviction by the H3K9me3S10ph “methyl/phospho switch” → stops Phase I HSV transcription (and VP16 expression).

Who’s to say an HPI like IM-250 isn’t altering epigenetic markers in viral episomes in this way? Innovative Molecules’ own press release states that some sort of permanent or semi-permanent modification may take place:

https://www.pharmaceutical-technology.com/analyst-comment/es...

>Furthermore, testing in animal models showed that adibelivir affected the latent viral reservoir, suggesting that it has potential as a long-term curative therapy for HSV.

New comment by mrtesthah in "Show HN: NoSuggest – Watch YouTube without the recommendation algorithm"

mrtesthah — Mon, 08 Jun 2026 05:24:05 +0000

This is desperately needed. I currently use https://freetubeapp.io/ but this seems to have more flexible deployment options.

New comment by mrtesthah in "New drug 'functionally cures' many hepatitis B virus infections"

mrtesthah — Mon, 08 Jun 2026 05:10:10 +0000

IM-250 (Adibelivir) is a helicase-primase inhibitor that targets latent HSV so well it may actually permanently reduce the pool of viable latent HSV genomes.

New comment by mrtesthah in "Anthropic surpasses OpenAI to become most valuable AI startup"

mrtesthah — Sat, 30 May 2026 16:10:23 +0000

>...sending money to China...

Have you seen the trade deficit lately?

New comment by mrtesthah in "The dead economy theory"

mrtesthah — Fri, 29 May 2026 16:44:41 +0000

https://aeon.co/essays/what-if-jobs-are-not-the-solution-but...

New comment by mrtesthah in "Project Glasswing: An Initial Update"

mrtesthah — Sat, 23 May 2026 02:35:45 +0000

I would say that if this sounds untenable to you, then you may want to consider that the way we architect software has itself been untenable for a while. What Mythos can accomplish today in public, an APT unit can already accomplish in secret.

New comment by mrtesthah in "CISA tries to contain data leak"

mrtesthah — Fri, 22 May 2026 23:13:24 +0000

It was a security contractor who leaked the creds. So this is already the increased privatization end-game.

New comment by mrtesthah in "Google I/O"

mrtesthah — Tue, 19 May 2026 18:38:08 +0000

All the frontier LLMs are multi-modal.

New comment by mrtesthah in "Google I/O"

mrtesthah — Tue, 19 May 2026 17:38:42 +0000

Gemini 3.5 is imminent.

https://www.voxelbench.ai/leaderboard

New comment by mrtesthah in "Kagi Snaps"

mrtesthah — Mon, 18 May 2026 01:21:38 +0000

I love all the customization features but I cannot use them with Privacy Pass sadly. Anonymity is more important to me.

New comment by mrtesthah in "At least 25 Flock cameras have been destroyed in five states since April 2025"

mrtesthah — Sun, 17 May 2026 17:44:59 +0000

Property destruction is not the same crime as battery/assault/etc.

Let’s not call breaking a camera “violence”.

New comment by mrtesthah in "Fecal transplants for autism deliver success in clinical trials (2019)"

mrtesthah — Sat, 16 May 2026 23:32:42 +0000

>but it’s such a complex theory

What's the theory now? I didn't propose any specific theory -- just noted a mechanism of influence.

New comment by mrtesthah in "Fecal transplants for autism deliver success in clinical trials (2019)"

mrtesthah — Sat, 16 May 2026 15:33:34 +0000

It makes sense for chocolate given that cocoa flavanols are prebiotic fiber for GABA-secreting bacteria which of course affects the parasympathetic nervous system.

New comment by mrtesthah in "Grand Theft Oil Futures: Insider traders keep making a killing at our expense"

mrtesthah — Mon, 11 May 2026 16:19:51 +0000

What we do know is that there was no evidence a few months prior and that Trump explicitly said that he was ignoring the clear lack of evidence in making his decision to attack.

New comment by mrtesthah in "Local AI needs to be the norm"

mrtesthah — Sun, 10 May 2026 23:55:45 +0000

>Coding, one of the most popular uses cases today, would not be great if it say only understood java to a version from years ago etc.

This LLM trained only and entirely on pre-1930s texts was able to code Python programs when given only a short example:

https://talkie-lm.com/introducing-talkie

New comment by mrtesthah in "Grand Theft Oil Futures: Insider traders keep making a killing at our expense"

mrtesthah — Fri, 08 May 2026 05:46:56 +0000

And? What actually changed during those few months?

New comment by mrtesthah in "Grand Theft Oil Futures: Insider traders keep making a killing at our expense"

mrtesthah — Thu, 07 May 2026 17:26:18 +0000

The US did in fact bomb the Iranian nuclear facilities in June 2025.

New comment by mrtesthah in "Permacomputing Principles"

mrtesthah — Thu, 07 May 2026 14:19:33 +0000

Nope, that poster is correct.

When we showed up with the anti-abortion message at first we failed. The evangelicals who had attended our seminars by tens of thousands when we were launching the first series just were not interested in the abortion issue. At first we were looking at empty seats in places like the Grand Ole Opry we’d filled a few years before.

It took a lot of hard work to change that apathy on the “issue.” And oddly what in the end gave the series credibility were the Republican political leaders who saw the chance to cash in on the issue. The fact they began to pay attention to Dad and me got evangelical leader’s juices flowing: They coveted our new access to power!

https://www.patheos.com/blogs/frankschaeffer/2014/07/the-act...

New comment by mrtesthah in "Permacomputing Principles"

mrtesthah — Thu, 07 May 2026 14:06:12 +0000

This is probably more of an attempt to make computing relevant to that “intersectional” subset of people who only consider a topic to be relevant if it relates to colonialism in some way.