<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: mwt</title><link>https://news.ycombinator.com/user?id=mwt</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Fri, 17 Apr 2026 06:11:22 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=mwt" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by mwt in "OpenAI backs Illinois bill that would limit when AI labs can be held liable"]]></title><description><![CDATA[
<p>Pharmaceuticals are heavily regulated, the "we vibecoded a therapeutic and released it without testing" hypothetical has no basis in reality</p>
]]></description><pubDate>Fri, 10 Apr 2026 14:29:28 +0000</pubDate><link>https://news.ycombinator.com/item?id=47718721</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=47718721</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47718721</guid></item><item><title><![CDATA[New comment by mwt in "OpenAI backs Illinois bill that would limit when AI labs can be held liable"]]></title><description><![CDATA[
<p>Would Doom give a sociopath instructions on how to commit a mass shooting if asked? I don't remember that part of the game</p>
]]></description><pubDate>Fri, 10 Apr 2026 14:27:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=47718697</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=47718697</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47718697</guid></item><item><title><![CDATA[New comment by mwt in "The Great Unwind"]]></title><description><![CDATA[
<p>Only through the first two paragraphs but a little turned off by the "everybody else is wrong, we are right and it's this one specific thing" attitude when it the topic is understanding something as complex and opaque as the global economy</p>
]]></description><pubDate>Wed, 04 Feb 2026 18:18:28 +0000</pubDate><link>https://news.ycombinator.com/item?id=46889462</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=46889462</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46889462</guid></item><item><title><![CDATA[New comment by mwt in "Parsing Chemistry"]]></title><description><![CDATA[
<p>The cheminformatics I do (mostly drug discovery/biophysics) definitely requires bonds!</p>
]]></description><pubDate>Wed, 12 Nov 2025 15:45:01 +0000</pubDate><link>https://news.ycombinator.com/item?id=45901571</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=45901571</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45901571</guid></item><item><title><![CDATA[New comment by mwt in "Parsing Chemistry"]]></title><description><![CDATA[
<p>I'd be really interested to know of anybody making money with those topics (and doesn't already have their own domain-specific practice for the problem)</p>
]]></description><pubDate>Wed, 05 Nov 2025 16:57:18 +0000</pubDate><link>https://news.ycombinator.com/item?id=45825103</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=45825103</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45825103</guid></item><item><title><![CDATA[New comment by mwt in "Parsing Chemistry"]]></title><description><![CDATA[
<p>This code is jibberish to me, but it appears the target is just parsing how many atoms are in a molecule string of some representation. That's cool, but to do just about anything useful in chemistry we need the bond graph (and often more - bond orders stereochemistry, plus much more for biopolymers).</p>
]]></description><pubDate>Wed, 05 Nov 2025 16:17:22 +0000</pubDate><link>https://news.ycombinator.com/item?id=45824649</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=45824649</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45824649</guid></item><item><title><![CDATA[New comment by mwt in "Amazon confirms 14,000 job losses in corporate division"]]></title><description><![CDATA[
<p>Much like the classic "our department in [big company] works a lot like a startup"</p>
]]></description><pubDate>Tue, 28 Oct 2025 13:41:41 +0000</pubDate><link>https://news.ycombinator.com/item?id=45732791</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=45732791</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45732791</guid></item><item><title><![CDATA[New comment by mwt in ""We're building a new static type checker for Python""]]></title><description><![CDATA[
<p>I'm a little surprised to see you dismiss type-checkers disagreeing with each other - there are more than a few cases of mypy and pyright disagreeing and brushing them aside as rare enough to be irrelevant is in conflict with my experience over the years.<p>I'm happy you believe that the community can converge on unified standards - I wish I shared the optimism - but that's not where we're currently at and years-long efforts don't help me now. (For example, I'd love to use PEP 695 generics since I found a use case for them around 18 months ago but I can't until I can get away with not supporting 3.11, which is years out.) Maybe everything is perfect in 2028 or so - I'd be thrilled - but that doesn't help the pitch for annotations being a value add for people who are worried about the current jobs.</p>
]]></description><pubDate>Thu, 30 Jan 2025 13:17:29 +0000</pubDate><link>https://news.ycombinator.com/item?id=42877417</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=42877417</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=42877417</guid></item><item><title><![CDATA[New comment by mwt in ""We're building a new static type checker for Python""]]></title><description><![CDATA[
<p>> as for the split in type checking tools, it is not as bad as you think<p>I'm surprised you already know it's not as bad as I think - have you been able to use it? Working on a team that mixes mypy and pyright is pretty frustrating since they don't agree on everything (i.e. when one changeset passes on one and fails on the other) and I see no reason to believe the inconsistencies will become more rare when the number of opinions goes from two to three</p>
]]></description><pubDate>Wed, 29 Jan 2025 22:23:08 +0000</pubDate><link>https://news.ycombinator.com/item?id=42872032</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=42872032</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=42872032</guid></item><item><title><![CDATA[New comment by mwt in "Astral – "We're building a new static type checker for Python""]]></title><description><![CDATA[
<p>Unfortunately that doesn't answer the question</p>
]]></description><pubDate>Wed, 29 Jan 2025 22:20:34 +0000</pubDate><link>https://news.ycombinator.com/item?id=42872001</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=42872001</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=42872001</guid></item><item><title><![CDATA[New comment by mwt in ""We're building a new static type checker for Python""]]></title><description><![CDATA[
<p>thanks, I didn't know it was a thread because of the login wall</p>
]]></description><pubDate>Wed, 29 Jan 2025 20:04:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=42870398</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=42870398</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=42870398</guid></item><item><title><![CDATA[New comment by mwt in ""We're building a new static type checker for Python""]]></title><description><![CDATA[
<p>kinda mixed on this<p>- why not just contribute to the community tool?<p>- there's already a major split in Python type-checking tools, if there's a third that doesn't agree with either of them it'll be a mess for projects to deal with<p>- astral has been hiring like mad recently and has yet to communicate that they can actually make  money ($5 million doesn't last forever)<p>- does it actually exist? is this currently a closed-source codebase, or is "we're building" future tense?</p>
]]></description><pubDate>Wed, 29 Jan 2025 19:57:24 +0000</pubDate><link>https://news.ycombinator.com/item?id=42870296</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=42870296</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=42870296</guid></item><item><title><![CDATA[New comment by mwt in "Faked Beta-Amyloid Data. What Does It Mean?"]]></title><description><![CDATA[
<p>> Is that related to some legal/privacy issue?<p>Possibly in some medical or social science fields, I don't know. I know there is not such an issue in chemistry and materials science. There also may be some complications for collaborations with industry, but that's kinda a different situation. For people whose career development is not strongly tied to reproducibility of their work (a.k.a. everybody) it's just another step in the overly complex process of publishing in for-profit journals. Funding agencies generally aren't going to punish people for using this excuse and the watchdogs/groups concerned with reproducibility have no teeth.<p>Not an excuse, but journals don't make it easy to share files, as hard as that is to believe. Some will only take PDFs for supplemental information and many have garbage UIs, stupidly small file size limits, etc. Just uploading to a repo (or tagged release) on GitHub is common these days because there is much less friction.</p>
]]></description><pubDate>Mon, 25 Jul 2022 16:13:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=32226480</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32226480</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32226480</guid></item><item><title><![CDATA[New comment by mwt in "Faked Beta-Amyloid Data. What Does It Mean?"]]></title><description><![CDATA[
<p>> I wonder if there is any requirement for researchers to at least publish their data set for statistical analysis and further research.<p>Not generally, though the tide is slowly turning in the right direction. Unfortunately many laws/policies pushing for openness and transparency in research are sidestepped with the classic "data available upon request," a.k.a. "I promise I'll share the Excel files if you email me" (they will not).</p>
]]></description><pubDate>Mon, 25 Jul 2022 15:57:37 +0000</pubDate><link>https://news.ycombinator.com/item?id=32226250</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32226250</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32226250</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>I'm not claiming there are no overly stubborn PIs. But we should not be lazy and paint so a brush that we view the field as a monolith.</p>
]]></description><pubDate>Sun, 24 Jul 2022 23:15:03 +0000</pubDate><link>https://news.ycombinator.com/item?id=32218764</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32218764</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32218764</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>I think there is truth to the general principle you refer to, but I don't think it accurately describes what I saw skimming experts' comments in the linked thread. I'm an outsider to medical research but have experience in other parts of STEM research at universities. Here I saw a plenty of nuance, documentation of historical skepticism, concern over broad perception, and plenty disagreement over technical points. Far from a unified kool-aid drinker sort of situation. And I think there has been plenty of changes of opinions in the Alzheimer's field in recent years given the number of failed drugs - which goes against the idea that these scientists are  following their career over the evidence.</p>
]]></description><pubDate>Sun, 24 Jul 2022 20:57:37 +0000</pubDate><link>https://news.ycombinator.com/item?id=32217636</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32217636</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32217636</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>Hopefully so, but there will probably always be a back-and-forth between frauds and journalists in the same way security is always a competition. At least the easy frauds are more likely to be caught today.</p>
]]></description><pubDate>Sun, 24 Jul 2022 15:04:52 +0000</pubDate><link>https://news.ycombinator.com/item?id=32214154</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32214154</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32214154</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>Harboring skepticism of the work people did with a seemingly fraudulent researcher is a good idea. Dismissing everybody in a field whether or not their work is fraudulent is disrespectful approach (not to mention useless).</p>
]]></description><pubDate>Sun, 24 Jul 2022 15:02:30 +0000</pubDate><link>https://news.ycombinator.com/item?id=32214132</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32214132</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32214132</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>I'm not asking for people to turn off skepticism or blindly trust researchers. It's not disrespectful to be skeptical.<p>What is disrespectful is not bothering to read what people have to say before dismissing them as liars who are too vested in "the current research direction" and/or money for their perspectives to matter. It only takes reading a few comments to see that's not happening - for starters, people were skeptical of this group's work for a while now.</p>
]]></description><pubDate>Sun, 24 Jul 2022 14:53:29 +0000</pubDate><link>https://news.ycombinator.com/item?id=32214061</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32214061</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32214061</guid></item><item><title><![CDATA[New comment by mwt in "Two decades of Alzheimer’s research was based on deliberate fraud"]]></title><description><![CDATA[
<p>> basically all images in scientific publications are not scrutinized for photoshop<p>This was (mostly) true back then, but it is definitely not true today. People tempted to commit fraud now have to be worried about people like Elisabeth Bik exposing them and ruining their careers. In my experience, the type of people known lie in papers overlap strongly with those that are career-minded/money-driven. So having a few journalists with the skills to detect fraud is an obvious win. Some of the frauds will just get better at, that's just how it does, but it's not like there are no imaging experts in the field.</p>
]]></description><pubDate>Sun, 24 Jul 2022 14:40:42 +0000</pubDate><link>https://news.ycombinator.com/item?id=32213920</link><dc:creator>mwt</dc:creator><comments>https://news.ycombinator.com/item?id=32213920</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32213920</guid></item></channel></rss>