Frontier models will continue to be either exclusively available from servers or significantly more affordable from servers vs local alternatives for the foreseeable future.

Another concept I like is that we should optimize for next year's AI. Don't migrate to a monorepo if your only motivation is the performance of today's agents, because a year from now this may be a non-issue. Of course other motivations may still be valid.

Re: unrefactorable, large components, you probably want to break these down into smaller pieces. This talk ("Composition is all you need") is an excellent guide on the topic: https://youtu.be/4KvbVq3Eg5w?si=1esmAtrJthois1uf

Re: performance, people overstate the performance overhead of VDOM. Badly performing React applications are virtually always due to bad implementations. React Scan is an excellent tool for tracking down components that need optimizing: https://react-scan.com/

Re: getting other people on the team to write good code, this is the biggest struggle IMO. Frontend is hard because there's a lot of bad ways to solve a problem, and co-workers will insist that their changes work so why invest more time into building things correctly. I've only found success here by first writing an entire feature with good patterns and pointing to it as reference for other teams. People are more willing to make changes if they find precedent in the codebase.

The idea that React is inherently slow is totally ignorant. I'm sympathetic to the argument that many apps built with React are slow (though I've not seen data to back this up), or that you as a developer don't enjoy writing React, but it's a perfectly fine choice for writing performant web UI if you're even remotely competent at frontend development.

Two most common types are osteoarthritis (wear-and-tear associated with aging and/or injuries) and rheumatoid arthritis (autoimmune).

I only know about age-related knee osteoarthritis to try to help my mom manage her symptoms, so I'll share my understanding of treating that.

High ROI, low cost: - weight management. Extra lbs are extra stress on the knees, plus I suspect chronic inflammation associated with being overweight can exacerbate arthritis independent of mechanical stress. - exercise, specifically low impact cardio and any pain-free strength/hypertrophy work targeting the musculature around the knees (mainly quads).

Variable ROI, low cost: - NSAIDs, specifically topical to focus on treatment area and reduce impact on GI system/kidneys. - curcumin, mixed evidence but some people report benefits.

Variable ROI, high cost: - PRP injections. Apparently the quality on these varies dramatically by provider. Would recommend doing research and comparing multiple providers if possible. - Knee replacement. Far from a panacea; you'll lose range of motion forever, plus plenty of other trade-offs. Most people recommend putting this off for as long as possible.

Also interesting is low dose radiation treatment for knee OA. More affordable than other procedures and has some promising research.

Not much else on the novel treatment front that I've found. Curious if anyone thinks I've missed anything worthwhile.

I'm just not convinced that removing Maduro is some horrible violation of international law. As I said in my original comment, I'd be more sympathetic to the argument that the US has a horrible track record with regime change.

Regardless, given the geopolitical significance of Venezuela's relationships with China and Iran it is ignorant to suggest that "[only Venezuelans have] a standing in the matter." And the illegitimacy of Maduro's election is not a topic of serious debate as your phraseology might suggest. He stole the election, he's bad for Venezuelans, and he's good for our geopolitical rivals. It is yet to be revealed whether our intervention will be a net positive.

I'm not sure this argument makes sense. Maduro stole an election to force his way to dictatorship, is widely blamed for running the country into mass poverty, and continues to hold onto power through threat of violence. The Venezuelan people don't have any recourse here.

Also, in your example of Ukraine you indicate that Russia frames the uprising as a "US coup", suggesting that the reality of whether there even was external involvement isn't so important.

Even so, if some nation tried to use this strike on Venezuela as further justification for violence wouldn't they be violating the same international law you cite anyway?

Obviously the US has a rough track record of replacing foreign governments (a much stronger argument against this kind of act IMO), but so far this mission has looked pretty ideal (rapid capture of Maduro, minimal casualties, US forces instead of funding some rebel group). There is opportunity for a good ending if we can steward a legitimate election for Venezuela, assist with restoration of key institutions (legal, police, oil), and we avoid any deals regarding oil that are viewed as unfair by the Venezuelans.

I've heard chatter from our engineering leadership that IBM is trying to push some silly initiatives, but we've been able to prioritize the right work so far.

I also get more equity (one time award + employee stock purchase plan) than I did previously, and with how IBM stock has been performing lately this has been a net positive for me.

FWIW I have heard that IBM used to force their management style on acquisitions in years past, so perhaps this is a fairly recent shift towards a less hands-on approach.

You are free to interpret the score within the broader context of your own experience, the problem domain your code addresses, time constraints, etc.

If there was some indication that the pharmaceutical company knew of and concealed evidence that finasteride caused depression/suicidality, then there could be grounds for criminal prosecution. But a non-consensus view in hindsight that a drug might increase depression looks more like a losing civil liability claim.

I also wonder whether there's some degree of placebo going on. Patients know finasteride is anti-androgenic; perhaps when they inevitably experience some symptoms associated with hypogonadism they assume the worst and lament the choice between having hair and feeling youthful. This would also explain why many who get off finasteride don't notice their symptoms improve.

Personal bias: I've taken finasteride for years with no side effects.

The author's definition of taste as a prioritization of various engineering values is one we can understand based on experience.

A confusing distinction to make in a thread about employment.

> It always fought against open source.

They've since admitted this was a mistake, and in 2020 were cited as the single largest contributor to open source projects: https://www.theverge.com/2020/5/18/21262103/microsoft-open-s...

> And now, it bought GitHub and then plagiarized all public and private projects hosted on it.

This is news to me. Are you claiming Microsoft/GitHub used or sold private source code for training LLMs?

The defeatist "all corps are evil" mentality will not do you any good.