Hacker News: notamy

New comment by notamy in "Agents Are Not Enough"

notamy — Fri, 10 Jan 2025 07:10:56 +0000

https://en.wikipedia.org/wiki/Quantum_biology

> Mitochondria have been demonstrated to utilize quantum tunneling in their function as the powerhouse of eukaryotic cells.

When the U.S. tried to replace migrant farmworkers with high schoolers (2018)

notamy — Wed, 08 Jan 2025 05:12:12 +0000

Article URL: https://www.npr.org/sections/thesalt/2018/07/31/634442195/when-the-u-s-government-tried-to-replace-migrant-farmworkers-with-high-schoolers

Comments URL: https://news.ycombinator.com/item?id=42631168

Points: 74

# Comments: 84

Do Kwon, the person behind $40B Luna/Terra collapse, extradited to US

notamy — Sat, 04 Jan 2025 04:05:23 +0000

Article URL: https://arstechnica.com/tech-policy/2025/01/do-kwon-the-crypto-bro-behind-40b-luna-terra-collapse-finally-extradited-to-us/

Comments URL: https://news.ycombinator.com/item?id=42592289

Points: 3

# Comments: 0

OpenAI defends for-profit shift as critical to sustain humanitarian mission

notamy — Fri, 27 Dec 2024 22:25:32 +0000

Article URL: https://arstechnica.com/tech-policy/2024/12/openai-defends-for-profit-shift-as-critical-to-sustain-humanitarian-mission/

Comments URL: https://news.ycombinator.com/item?id=42526633

Points: 4

# Comments: 1

A Minecraft server written in COBOL

notamy — Thu, 26 Dec 2024 03:59:54 +0000

Article URL: https://github.com/meyfa/CobolCraft

Comments URL: https://news.ycombinator.com/item?id=42513022

Points: 344

# Comments: 121

New comment by notamy in "Parsing millions of URLs per Second (2023)"

notamy — Tue, 24 Dec 2024 00:25:01 +0000

The title seems to have a few words missing. Original title:

> Parsing millions of URLs per second

Commercial tea bags release microplastics, entering human intestinal cells

notamy — Sun, 22 Dec 2024 16:09:03 +0000

Article URL: https://medicalxpress.com/news/2024-12-commercial-tea-bags-millions-microplastics.html

Comments URL: https://news.ycombinator.com/item?id=42487187

Points: 2

# Comments: 0

New comment by notamy in "Gemini 2.0: our new AI model for the agentic era"

notamy — Wed, 11 Dec 2024 17:00:54 +0000

> For the more Java proficient, can someone explain why it may have provided this code:

To me that reads like it was trying to accomplish something like

    int[] current;
    while((current = queue.pop()) != null) {

Apple hit with $1.2B lawsuit after killing controversial CSAM-detecting tool

notamy — Tue, 10 Dec 2024 04:59:02 +0000

Article URL: https://arstechnica.com/tech-policy/2024/12/thousands-of-child-sex-abuse-victims-sue-apple-for-lax-csam-reporting/

Comments URL: https://news.ycombinator.com/item?id=42373909

Points: 6

# Comments: 1

New comment by notamy in "Insects rely on sounds made by distressed vegetation to guide reproduction"

notamy — Sun, 08 Dec 2024 17:17:43 +0000

It’s been shown that sesquiterpenes released by plants can induce cloud formation: https://www.science.org/doi/10.1126/sciadv.adi5297

I now wonder if they use the sound to communicate with other plants to try to get clouds to form faster

New comment by notamy in "A Kid Made $50k Dumping Crypto He'd Created. Then Came the Backlash"

notamy — Sat, 07 Dec 2024 00:39:44 +0000

http://archive.today/nwYcd

New comment by notamy in "Hit men aren't what you think"

notamy — Fri, 06 Dec 2024 18:21:50 +0000

http://archive.today/gM6MG

China hits US with ban on critical minerals used in tech manufacturing

notamy — Tue, 03 Dec 2024 21:06:12 +0000

Article URL: https://arstechnica.com/tech-policy/2024/12/china-retaliates-bans-exports-of-rare-metals-after-us-chip-ban/

Comments URL: https://news.ycombinator.com/item?id=42311424

Points: 3

# Comments: 0

Enron has been resurrected in what appears to be an elaborate joke

notamy — Tue, 03 Dec 2024 13:52:19 +0000

Article URL: https://www.cnn.com/2024/12/02/business/enron-resurrected-joke-nightcap/index.html

Comments URL: https://news.ycombinator.com/item?id=42306009

Points: 3

# Comments: 0

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 14:33:01 +0000

> Subligual methylcobalamin works just as well as the shots

It does not. The cobalamin molecules are quite large and don’t penetrate the sublingual mucosa very well. On top of that, the proteins in saliva that bind to B12s will cause any bound B12 to not absorb sublingually, instead having to wait to make it through the digestive system for intestinal uptake.

Sublingual is still certainly a better option than oral pills, but the injections are preferable in severe cases for a reason.

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 05:33:40 +0000

> Megadosing it can harm sleep and severely increase blood pressure and heart rate

https://www.researchgate.net/profile/Osama-Arafat/publicatio...

> METHYLCOBALAMIN HAS AN EFFECT ON HYPOTHALAMIC–HYPOPHYSEAL– ADRENAL AXIS

In rats, but may apply to humans too.

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 05:31:15 +0000

> I suspect that copper is the issue with me.

Prolonged copper deficiency can cause irreversible neuropathies and CNS damage. You should try to get tested for it if you can.

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 04:42:40 +0000

> Apparently this form of B9 absorbs better if it’s combined with the methylated form of B12 (methylcobalamin)

B9 and B12 are interdependent. When the body uptakes cobalamins, the ligands are pulled off and replaced with ligands sourced from other processes. IIRC in the case of methylcobalamin, the methyl group is pulled off and replaced with a methyl group that’s moved over from methylfolate via a riboflavin-dependent reaction. Been a hot minute since I looked into this so I may have some details incorrect.

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 04:27:54 +0000

> The paradoxical B12 deficiency might have a relation with the inactive form being supplemented.

Yup, not everyone can convert cyanocobalamin or hydroxocobalamin to adenosyl-/methylcobalamin. Especially in severe cases, anecdotally I’ve seen people not make progress with the standard cyanocobalamin injections, but then make huge progress with methylcobalamin injections. Unfortunately, methylcobalamin is often not preferred in injectable form due to very quick degradation into hydroxocobalamin upon exposure to light.

New comment by notamy in "Premature Graying of Hair: Review with Updates"

notamy — Tue, 26 Nov 2024 04:24:10 +0000

It may help, but it will also throw off lab tests while you’re taking it and for a time after. Also, B12 absorption depends strongly on good gut health (ex. no SIBO[1], low gastric acid, pernicious anaemia, etc.), as well as on other medications (ex. metformin[2]) not interfering with absorption.

[1] https://en.wikipedia.org/wiki/Small_intestinal_bacterial_ove...

[2] https://en.wikipedia.org/wiki/Metformin CTRL-F "B12"