Thing is, GameStop is, well, for videogames and videogame paraphernalia. It's not a general store. Doing this would turn them into a thrift shop, not a pawn shop, as people are trying to offload their carpets, desks, etc - bulky stuff.

I don't think this makes sense.

This does make sense when you consider the collectable market, another domain I'm involved in. Trading card games, specifically pokemon, have exploded over the last 5 years. GameStop is making a killing off of buying, selling, and grading these cards. Ebay is the primary marketplace to buy and sell those cards. There's also tax free havens ("Vaults") offered by multiple companies, grading service passthroughs, and scalping offered through ebay too.

Viewed through the above lens, that's what's prompting this offer, I think.

You would be astonished at how little it takes to bribe, I mean donate, to a politician for example. For as little as $10-20k USD you can get a literal seat at a table with a sitting senator or congresscritter for several hours at a "charity" dinner, with results as expected.

We do not understand these ecosystems beyond their extreme fragility and low entropy conditions. This is an incredibly destructive and expensive manner of resource extraction that destroys the seabed. Why would anyone sane ever support this beyond, I don't know, someone who also thinks that clearcutting the amazon is a good idea? What kind of vested interest do you have in this blighted technology?

This drug has been used in a huge number of patients for more than 11 years; the next gen of drugs is currently being used. I'm sorry for my curt style of writing, but - people like your father have helped pave the way for that next generation of drugs by constraining clinical trial designs.

Several things trigger my bullshit meter. Quote:

"This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"

PD-L1 monoclonal antibodies are only effective against cancers that are, you guessed it, PD-L1 positive. At high percentages, ranging from 1 to 50%. Are these authors even familiar with the state of the art when it comes to cancer medications? Mouse tumors do not equate to people tumors. Many tumor types are not PD-l1 positive.

Doxy is an ancient SOC chemo.

This is a nothing burger.

Give me phase II/III clinical trials, and then let me know what their PFS/OS was after 5 years. and what the medians were at 3- and 5-years. Also, ORR and CR and needed.

CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.

Shouldn't be too bad; USGS forecasts up to 1 meter tsunami.

While I applaud the use of alternatives to windows and it's apps, universities teach it because it is what their graduates will use in the real world. Governments use it because while it has it's flaws, it mostly works and is a universal standard. It's the toyota of operating systems. The parts and manpower to repair it and use it are available everywhere, and it's cheap and reliable.

> "This latest project will use locally available natural sand, held in a container 14m high and 15m wide."

-"a SBH could be artificially created by firing a huge number of gamma rays from a spherically converging laser. The idea is to pack so much energy into such a small space that a BH will form."

1. https://arxiv.org/abs/0908.1803

The human compatibility issues with microgravity are well known, as is the solution, which has even been proposed by NASA: centripetal force to create 1G for the astronauts.

As far the the radiation goes, we do indeed know exactly what kinds of radiation they would encounter. And the easiest way to shield humans from it in space is lots of water, or metal. We know this from extensive real work done on earth re: nuclear power plants.

The real issue is money, not technical feasibility. Once the dough rolls in from asteroid mining, it bootstraps the financing issue and pays for itself many times over.