Hacker News: ohbleek

New comment by ohbleek in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"

ohbleek — Tue, 16 Jun 2026 01:34:32 +0000

Thank you for writing out this reply, so I didn't have to. I think that somebody who is not working in medicine or pharma at all would not be able to understand how views have shifted concerning the amyloid-plaque theory. It is largely discussed as a theory that has been tested extensively and has only highlighted our lack of understanding of Alzheimer pathophysiology.

That last part isn't a sidenote, it's the entire reason for discussing the theory.

New comment by ohbleek in "All phones sold in the EU to have replaceable batteries from 2027"

ohbleek — Mon, 20 Apr 2026 19:55:37 +0000

A quick google will show you’re relying too much on your own views of what people desire for phone improvements. This law will lead to much needed changes and improvements in a mature and arguably stale market.

New comment by ohbleek in "Uploading Pirated Books via BitTorrent Qualifies as Fair Use, Meta Argues"

ohbleek — Sat, 07 Mar 2026 12:36:01 +0000

So, does this mean that people can simply argue in court now (if they were to be prosecuted for downloading media via bittorrent) that it is fair use if they used it to train a local model on their machine?

New comment by ohbleek in "Statement from Dario Amodei on our discussions with the Department of War"

ohbleek — Fri, 27 Feb 2026 13:07:49 +0000

To quote Brennan Lee Mulligan, "Laws are threats made by the dominant socioeconomic ethnic group in a given nation."

New comment by ohbleek in "Rathbun's Operator"

ohbleek — Fri, 20 Feb 2026 12:57:57 +0000

The tone of their writing and their descriptions of the agents behavior lead me to believe they are lying about the level of direction they provided to the agent. They clearly want to appear to be more clever and ingenious than their skills will allow. They’re minimally admitting to a narrow set of actions to make it seem as if they have cleverly engineered an intelligent agent, but it too closely resembles their own personality to be anything beyond an agent that rephrases the operator’s own remarks and carried out the specific actions it was directed to do. Anything they admit to here we can safely speculate that they actually went 2-3 steps further.

New comment by ohbleek in "Y Combinator CEO Garry Tan launches dark-money group to influence CA politics"

ohbleek — Wed, 11 Feb 2026 23:11:41 +0000

“Study after study shows that money doesn't really effect the results of high-information elections“

Your earlier statement, in which you claim that “money doesn’t effect result” followed by a useless distinction of high or low info elections. You’re really trying to dance a fine line of nonsense here.

“ We find a positive and statistically significant relationship between campaign expenditure, campaign contributions and winning probability.”

From the same article you posted and the first academic journal result if you Google “studies on how money influences elections”.

New comment by ohbleek in "Surely the crash of the US economy has to be soon"

ohbleek — Sat, 31 Jan 2026 20:27:09 +0000

That spark could end up being the rollout of chinas digital currency to the world and requiring payment using that currency when dealing with foreign businesses. This will kill the position of the US dollar as a reserve currency, slowly, but almost certainly.

New comment by ohbleek in "Show HN: I Ching simulator with accurate Yarrow Stalk probabilities"

ohbleek — Mon, 15 Dec 2025 20:58:24 +0000

I believe that is what is listed at the bottom of the page.

New comment by ohbleek in "Fewer students are enrolling in doctoral degrees"

ohbleek — Fri, 14 Feb 2025 03:08:30 +0000

>I thnk it does occur to people, but that's a choice for nepo babies and aspiring monks.

Maybe you've only spent time around PhD candidates at Ivy League schools where people are more likely to have access to wealth, but if you've spent any time at all around PhD candidates you'll find this is generally not the case. As a PhD candidate from a lower SE class, I've found that the majority of my peers are from a similar class. However, I am not connected to a private university though I am in medicine.

Studies on this show great variation across doctoral fields. Economics doctoral students tend to come from more affluent backgrounds, while the majority of Social Sciences doctoral students are from a lower SE class. Overall there seems to be a trend that doctoral students in fields with more lucrative career prospects tend to come from a higher SE class.

From what I have read, your claim only applies to the majority of faculty members, which tend to come from backgrounds with an income that is higher than the national median income.

New comment by ohbleek in "Losing my son"

ohbleek — Thu, 18 Jan 2024 18:41:55 +0000

Thank you for sharing these. My brother was murdered a year ago and today I’m trying to finish writing my victim impact statement to be read at the sentencing of his killer. I’ve been frozen in my processing for several days and your descriptions helped me place myself back in my body as I tend to disassociate when faced with the overwhelming grief of his loss.

New comment by ohbleek in "Researchers discover neuronal biomarkers of schizophrenia in the blood"

ohbleek — Tue, 26 Dec 2023 08:34:25 +0000

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181763/

>Initially during the prodrome, a change in brain structure seems to be present in the temporal lobe volume and cingulated. On follow-up in those who have gone onto a psychotic episode, further changes can be seen in the cingulate, temporal lobe, and parahippocampal gyrus.

Structural changes occur before an episode has even occurred.

New comment by ohbleek in "Researchers discover neuronal biomarkers of schizophrenia in the blood"

ohbleek — Tue, 26 Dec 2023 08:30:57 +0000

Nobody with clinical experience or even an educational background in psychopharmacology/medicine would make a comment like this. Antipsychotics are given with great caution as many have extrapyramidal effects and a few even require REMS programs.

New comment by ohbleek in "How could Al Bundy afford a house when he was making minimum wage?"

ohbleek — Tue, 28 Nov 2023 01:46:14 +0000

Thank you for adding this information. It shows how important it is to get granular with data otherwise so much nuance gets lost in the interpretation.

New comment by ohbleek in "OpenAI's board has fired Sam Altman"

ohbleek — Sat, 18 Nov 2023 06:06:05 +0000

This is gold.

New comment by ohbleek in "OpenAI's board has fired Sam Altman"

ohbleek — Sat, 18 Nov 2023 06:01:57 +0000

It does seem like any sufficiently advanced AGI that has the primary objective of valuing human life over it's own existence and technological progress, would eventually do just that. I suppose the fear is that it will reach a point where it believes that valuing human life is irrational and override that objective...

New comment by ohbleek in "OpenAI's board has fired Sam Altman"

ohbleek — Sat, 18 Nov 2023 05:55:14 +0000

Ok, but it fits so well with "liar, liar, pants on fire" and their reason for dismissal.

New comment by ohbleek in "OpenAI's board has fired Sam Altman"

ohbleek — Sat, 18 Nov 2023 05:45:08 +0000

Thank you, this was very helpful. I was beginning to feel overwhelmed by the volume of information and opinions.

New comment by ohbleek in "OpenAI's board has fired Sam Altman"

ohbleek — Sat, 18 Nov 2023 05:38:40 +0000

Am I misunderstanding his answer, or does he not essentially say it should be "descriptive"? In which case, I misunderstood what your comment is implying.

New comment by ohbleek in "Scientists identify pathway activated by interferon-gamma leading to tumor death"

ohbleek — Thu, 19 Oct 2023 11:21:59 +0000

lovely

New comment by ohbleek in "Drinking diet sodas daily during pregnancy linked to autism in male offspring"

ohbleek — Tue, 03 Oct 2023 23:37:08 +0000

>Diet Coke, which contains significantly more caffeine than regular Coke

It is true that Diet Coke has a higher caffeine content. Though I would not say it is significant:

A 12 oz. can of Coke contains 32 mg, Diet Coke contains 42 mg

A difference of 10 mg is not significant in this context.