Hacker News: oskarpearson

Accelerating life sciences research

oskarpearson — Sat, 30 Aug 2025 03:35:41 +0000

Article URL: https://openai.com/index/accelerating-life-sciences-research-with-retro-biosciences/

Comments URL: https://news.ycombinator.com/item?id=45071703

Points: 51

# Comments: 6

New comment by oskarpearson in "Ellison's EIT buys Eagle and Child pub"

oskarpearson — Thu, 26 Oct 2023 10:37:37 +0000

The Eagle & Child pub in Oxford was frequented by CS Lewis and Tolkien. It’s now going to be refurbished by Foster and Partners architects

Ellison's EIT buys Eagle and Child pub

oskarpearson — Thu, 26 Oct 2023 10:37:37 +0000

Article URL: https://www.bbc.co.uk/news/uk-england-oxfordshire-67221202

Comments URL: https://news.ycombinator.com/item?id=38023856

Points: 2

# Comments: 1

New comment by oskarpearson in "Tiger bread – rice flour paste"

oskarpearson — Sat, 29 Jul 2023 09:35:41 +0000

I was interested in how they make Tiger bread.

Turns it it’s rice-flour paste and yeast painted on prior to baking. The rice flour doesn’t stretch, so flakes when the bread expands

Tiger bread – rice flour paste

oskarpearson — Sat, 29 Jul 2023 09:35:41 +0000

Article URL: https://en.wikipedia.org/wiki/Tiger_bread

Comments URL: https://news.ycombinator.com/item?id=36918473

Points: 4

# Comments: 2

New comment by oskarpearson in "Launch HN: PeerDB (YC S23) – Fast, Native ETL/ELT for Postgres"

oskarpearson — Thu, 27 Jul 2023 20:25:36 +0000

We use DMS in continuous replication mode, which appears to use CDC under the hood according to https://docs.aws.amazon.com/dms/latest/userguide/CHAP_Task.C...

In our setup DMS pushes Parquet files on s3. Snowflake then loads data from there.

We’ve occasionally had to do a full table sync from scratch, which is painfully slow. We are going to have to do that in the very near future - when we are upgrading from Postgres 11 to Postgres 15.

The S3 step also seems unnecessarily complicated, since we have to expire data from the bucket.

How does PeerDB handle things like schema changes? Would the change replicate to Snowflake? (I’m sure this is in the docs, but I’m supposed to be on holiday this week ) Thanks for the quick reply.

New comment by oskarpearson in "Launch HN: PeerDB (YC S23) – Fast, Native ETL/ELT for Postgres"

oskarpearson — Thu, 27 Jul 2023 19:54:39 +0000

Seems like a really useful tool. Would your system support Postgres Aurora on AWS as a source database? Or does it require some lower-level access to Postgres server?

We are currently using DMS to send data to S3 and from there to Snowflake.

New comment by oskarpearson in "What happens when babies are left to cry it out?"

oskarpearson — Thu, 29 Dec 2022 21:22:29 +0000

From the article:

> For others, it can be hours of crying, even to the point of vomiting (common enough to be a frequent topic of conversation on sleep-training forums and addressed by baby sleep books including Ferber's

The article also includes a reference to 2-3 hours.

New comment by oskarpearson in "Improving Postgres text search speed"

oskarpearson — Sat, 13 Aug 2022 22:36:07 +0000

AWS’s DMS has a dynamodb target.

https://docs.aws.amazon.com/dms/latest/userguide/Welcome.htm...

New comment by oskarpearson in "The Reliability of Optical Disks"

oskarpearson — Sat, 02 Apr 2022 17:51:12 +0000

The article covers m-disc extensively, not sure why you’re linking Wikipedia here?

New comment by oskarpearson in "High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape"

oskarpearson — Mon, 20 Sep 2021 22:12:16 +0000

https://en.m.wikipedia.org/wiki/Human_challenge_study

New comment by oskarpearson in "High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape"

oskarpearson — Mon, 20 Sep 2021 22:09:26 +0000

For the same reason most vaccines require two doses. And for the same reason some countries are planning or doing booster shots.

Antibody levels drop rapidly after an infection, if they persist at all.

Getting a vaccination after infection re-triggers the immune system and makes antibodies more likely to persist for longer.

Reading up on this many months ago it seemed likely that natural infection plus a single vaccination would be equivalent to two vaccine shots.

There was research about only needing to give one shot of vaccines like AstraZeneca to people with previous infection. It was considered too complex to manage, and the research as to efficacy wasn’t finalised, so they stuck with two.

Having had Covid, plus two shots of something like AstraZeneca is presumably somewhere in the region of a standard two-shot-plus-booster campaign.

I don’t really understand much of this paper, but given other comments it seems to be a reasonable idea.

New comment by oskarpearson in "Ask HN: What would a car engine look like that was robot serviceable?"

oskarpearson — Sat, 13 Mar 2021 15:57:41 +0000

Having read that EVs are more reliable in the past, I was surprised at your response.

https://www.quora.com/Are-electric-cars-more-reliable/answer... seems quite comprehensive.

Overall, they should be more reliable, though it’s early days and there are teething problems. At the moment they are at least at a similar level to Petrol engines.

https://www.fleetnews.co.uk/news/latest-fleet-news/2019/09/0... supports this.

ICE cars contain a chunk of metal that is guaranteed to wear out from day 1 of the purchase due to friction and combustion effects. So overall not that different.

New comment by oskarpearson in "Cocktail of flu, HIV drugs appears to help fight coronavirus: Thai doctors"

oskarpearson — Mon, 03 Feb 2020 06:52:47 +0000

In the article they explain that the doctor increased only the dosage of one drug - Oseltamivir. That drug is better known as Tamiflu, which doesn’t relate to your conjecture about the Thai doctor’s state of mind.

I’m strongly inclined to believe the other commenters in this thread.

> “We have been following international practices, but the doctor increased the dosage of one of the drugs,” said Somsak Akkslim, director-general of the Medical Services Department, referring to the flu medicine Oseltamivir.

New comment by oskarpearson in "Magic Roundabout (Swindon)"

oskarpearson — Thu, 23 Jan 2020 14:01:08 +0000

https://en.m.wikipedia.org/wiki/Roundabout#Turbo_roundabouts English link

New comment by oskarpearson in "Magic Roundabout (Swindon)"

oskarpearson — Thu, 23 Jan 2020 13:59:40 +0000

From tfa:

> In 2010, the National Cooperative Highway Research Program concluded that the roundabout reduces injurious crashes by three quarters

New comment by oskarpearson in "Tesla Cybertruck"

oskarpearson — Fri, 22 Nov 2019 06:32:46 +0000

I really like the design. It seems like the sci-fi car designs from my childhood are finally here.

I just found this! https://www.motor1.com/photo/486061/1980-citroen-karin-48606...

Gods in Color' returns antiquities to their original, colorful grandeur

oskarpearson — Wed, 07 Aug 2019 06:06:48 +0000

Article URL: https://edition.cnn.com/style/article/gods-in-color-ancient-world-polychromy/index.html

Comments URL: https://news.ycombinator.com/item?id=20632314

Points: 1

# Comments: 0

New comment by oskarpearson in "Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders"

oskarpearson — Sun, 14 Apr 2019 12:53:34 +0000

Hi Miguel. It wasn’t behind a paywall for me. Thanks for clarifying - and I apologise for being snarky.

New comment by oskarpearson in "Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders"

oskarpearson — Sun, 14 Apr 2019 11:10:19 +0000

Please refrain from simply quoting the article, adding nothing to the conversation. It’s a blatant attempt at upvote harvesting from the TLDR crowd, and doesn’t belong on HN