Hacker News: persedes

New comment by persedes in "The worthlessness of Vitamin D is mildly exaggerated"

persedes — Tue, 23 Jun 2026 20:59:42 +0000

Not in the field, but every time vitamin D studies come up I am reminded of the one that called out how current recommendations are based on faulty math (confusion on how to combine different sized studies confidence ranges ) and miss the mark significantly (and a lot of studies are based on those recommendations...)

https://pmc.ncbi.nlm.nih.gov/articles/PMC5541280/

New comment by persedes in "Plotnine"

persedes — Tue, 23 Jun 2026 14:49:04 +0000

Love plotnine when I switched over to python and great to see the project develop! But I have to admit I ended up switching to altair after all which has been my go to in python now.

New comment by persedes in "Rio de Janeiro's "homegrown" LLM appears to be a merge of an existing model"

persedes — Mon, 15 Jun 2026 17:21:19 +0000

It was a business trip, but yeah.

New comment by persedes in "Rio de Janeiro's "homegrown" LLM appears to be a merge of an existing model"

persedes — Mon, 15 Jun 2026 15:26:03 +0000

Parent was referring to the cost of hardware. I've had colleagues from brazil visit the US and go absolutely crazy at best buy to grab as much hardware as they could (laptops, nintendo switch, etc), because it's prohibitively expensive for them to buy that at home.

New comment by persedes in "Swiss voters reject proposal to cap population at ten million"

persedes — Sun, 14 Jun 2026 18:55:43 +0000

As an anecdote re Germans: A friend of mine did an Auslandssemester there and was surprised to see "No Germans" signs for some of the housing options. Always makes me chuckle as an example how "relative" xenophobia is.

New comment by persedes in "How much of Thermo Fisher's antibody data has been manipulated?"

persedes — Mon, 08 Jun 2026 13:31:38 +0000

Doing a western blot right takes a bit of practice and there are a couple failure modes you need to watch out for. Stuff like background "noise", smears, drifts can make it hard to get binary decision out of your experiment. E.g. antibodies are usually very very specific, but they can have impurities, unspecific bindings to other proteins etc which make interpretation harder. If they remove these from the advertised images you'll have a hard time comparing your own results to them. ESPECIALLY if they remove whole bands from the gel picture, which imho should be very much verboten.

Typically these catalogues have some numbers with regards to the antibodies binding affinity / impurities so you can have a general idea of what to expect, but having a clean image might mislead you into thinking that you did something wrong in your own setup. Seeing how wide spread it is, it's easy to imagine that their own lab is not run very "cleanly" and they have antibody contaminations in their gels, or issues with their own protocol that they're trying to edit out. Doubt that's the case, but it's really not a good look.

New comment by persedes in "Dreamliner front gear collapses at FRA"

persedes — Sun, 07 Jun 2026 14:01:40 +0000

Looks like a manual override was triggered.

Dreamliner front gear collapses at FRA

persedes — Sun, 07 Jun 2026 14:01:40 +0000

Article URL: https://www.dw.com/en/germany-lufthansa-plane-suffers-nose-gear-collapse/a-77423104

Comments URL: https://news.ycombinator.com/item?id=48434965

Points: 2

# Comments: 2

New comment by persedes in "Show HN: Bio Glyph – Turn Your Face into a One-Line Drawing"

persedes — Thu, 04 Jun 2026 00:22:11 +0000

Very cool and love the animation, but does not seem to work well with beards :D

New comment by persedes in "Gooey: A GPU-accelerated UI framework for Zig"

persedes — Wed, 03 Jun 2026 21:00:50 +0000

not the maintainer, but at first I thought it was python :D

https://github.com/chriskiehl/Gooey

New comment by persedes in "Show HN: Id-agent – Token efficient UUID alternative for AI agents"

persedes — Tue, 19 May 2026 13:01:47 +0000

yes, wondering if a simple pre/post llm processing would be enough?

New comment by persedes in "Bitwarden scrubs 'Always free' and 'Inclusion' values from its site"

persedes — Fri, 15 May 2026 14:06:34 +0000

urgh of course it has to be private equity. Really liked the product and did not mind paying for it...but not ready for the PE enshittification.

New comment by persedes in "USDA Projects Smallest US Wheat Harvest Since 1972 Due to Plains Drought"

persedes — Thu, 14 May 2026 14:25:43 +0000

It is...? H-mart + Wegmans has tofu at ~$2.5 for a 400g block. The cheapest bulk pork is at $2.6, but most portions / cuts sell at $4.

New comment by persedes in "DeepSeek v4"

persedes — Fri, 24 Apr 2026 14:21:38 +0000

not soooo much though. It's heavily subsidized for residential consumption, but industrial power rates are almost comparable to the US (depends on the state you go to etc).

New comment by persedes in "Workspace Agents in ChatGPT"

persedes — Thu, 23 Apr 2026 13:46:52 +0000

it's funny how adding AI to notion actually made it a lot more usable. Most products force it on you, but here I feel like it's actually a massive benefit. It was hard finding content and using the filters felt clunky. (And the whole UI either in a browser or their app feels buggy + slow). But with their notion AI / MCP it's gotten super easy to get information in and out.

New comment by persedes in "ggsql: A Grammar of Graphics for SQL"

persedes — Mon, 20 Apr 2026 17:56:48 +0000

Soo can I put this on top of e.g. grafana?

New comment by persedes in "Claude Opus 4.7"

persedes — Thu, 16 Apr 2026 15:08:15 +0000

Interesting that the MCP-Atlas score for 4.6 jumped to 75.8% compared to 59.5% https://www.anthropic.com/news/claude-opus-4-6

There's other small single digit differences, but I doubt that the benchmark is that unreliable...?

New comment by persedes in "Anatomy of the .claude/ folder"

persedes — Fri, 27 Mar 2026 17:39:54 +0000

huh neat, somehow completely missed out on the rules/ + path filters as a way to extend CLAUDE.md

New comment by persedes in "Tell HN: Litellm 1.82.7 and 1.82.8 on PyPI are compromised"

persedes — Tue, 24 Mar 2026 14:27:28 +0000

there's probably a more precise way, but if you're on uv:

  rg litellm  --iglob='*.lock'

New comment by persedes in "If DSPy is so great, why isn't anyone using it?"

persedes — Mon, 23 Mar 2026 17:28:28 +0000

funnily enough the model switching is mostly thanks to litellm which dspy wraps around.